Background Burn injuries are highly variable and dynamic. The outcome of patients is influenced by various factors requires prompt therapeutic interventions, including fluid resuscitation, for a favorable result. Although having varying shortcomings, many scoring indexes developed validated in Western countries to predict mortality burn patient. Abbreviated Severity Index (ABSI) estimates survival expectancy patient via negative prognostic factors. This study describes the pattern validate...

To better understand the poor conservation of helicase binding domain primases (DnaGs) among eubacteria, we determined crystal structure Helicobacter pylori DnaG C-terminal (HpDnaG-CTD) at 1.78 Å. The has a globular subdomain connected to helical hairpin. Structural comparison revealed that subdomains, despite variation in number helices, have broadly similar arrangements across species, whereas hairpins show different orientations. Further, study helicase-primase interaction H. pylori,...

Introduction Liver abscesses are rare, but whenever they occur, it is predominantly among males over 60 years of age. The paradigm in the treatment has changed, and percutaneous drainage now initial for abscesses. Open surgery reserved patients with septated those greater than 5 cm. Objective To study etiological, clinical, pathological, demographic characteristics individuals liver to evaluate outcome associated different strategies. Methods This clinico-epidemiological was carried out at a...

Helicobacter pylori causes gastritis, gastric ulcer and cancer. Though DNA replication its control are central to bacterial proliferation, pathogenesis, virulence and/or dormancy, our knowledge of synthesis in slow growing pathogenic bacteria like H. is still preliminary. Here, we review the current understanding replication, restart recombinational repair pylori. Several differences have been identified between Escherichia coli machineries including absence DnaC, helicase loader usually...

We followed the position of replication complex in pathogenic bacterium Helicobacter pylori using antibodies raised against single-stranded DNA binding protein (HpSSB) and replicative helicase (HpDnaB). The origin, oriC, was also localized growing cells by fluorescence situ hybridization (FISH) with fluorescence-labeled sequences adjacent to origin. replisome assembled at oriC near one cell poles, two forks moved together toward center as progressed cell. Termination resolution occurred...

Replicative helicases are major motor proteins essential for chromosomal DNA replication in prokaryotes. Usually hexameric solution, their binding property must have different roles at stages ranging from the loading onto a branched structure initiation origin to highly processive translocation during elongation. Here, we analysed activity of Helicobacter pylori (Hp) replicative helicase, DnaB. The results indicate that while C-terminal region is important its activity, N-terminus appears...

DNA replication in Helicobacter pylori is initiated from a unique site (oriC) on its chromosome where several proteins assemble to form functional replisome. The assembly of H. machinery similar that the model gram negative bacterium Escherichia coli except for absence DnaC needed recruit hexameric DnaB helicase at replisome site. In an obvious homologue pylori, question arises as whether HpDnaB loaded Hp-replication origin by itself or assisted other unidentified protein(s). A...

Communicated by Ramaswamy H. Sarma

Locally advanced breast cancer (LABC) is a subset of characterized by the most tumours in absence distant metastasis. Treatment LABC has evolved from single modality treatment to multimodality management. Neoadjuvant chemotherapy (NACT) increasingly being used treat patients with LABC. This study assessed tumour response after NACT using clinical changes, Response Evaluation Criteria Solid Tumors (RECIST) criteria and pathological report.This was prospective as well retrospective...

Background Ventral hernias are the second most common type of accounting for 21-35% all hernia types. includes incisional, umbilical, epigastric, and Spigelian hernias, among others. Currently, patients surgeons prefer laparoscopic repair ventral hernias. This study aimed to compare with open in terms various operative patient parameters. Methodology was a prospective observational conducted Department General Surgery, Dr. Sampurnanand Medical College, Jodhpur. All admitted diagnosis mesh...

Background Glioblastoma is the most frequent and aggressive primary malignant brain tumor in adults. Standard treatment includes surgical removal of followed by concomitant chemotherapy radiotherapy. Temozolomide, an oral alkylating agent, currently commonly used chemotherapy. However, median survival glioblastoma multiforme (GBM) patients remains very low. Epidermal growth factor receptor variant III (EGFRvIII) a novel marker for GBM Indian origin as few studies have been done on this...

India has a high COVID-19 burden. The Indian government responded to the pandemic by mandating its population adhere certain Protective Measures (PMs). Compliance these PMs depends on their acceptability and adaptability among general public.

DNA replication and cell division are two fundamental processes in the life cycle of a cell. The majority prokaryotic cells undergo by means binary fission coordination with genome. Both processes, but especially their coordination, poorly understood Helicobacter pylori . Here, we studied divisome assembly subsequent membrane peptidoglycan synthesis bacterium. To our surprise, found to be polar, which was well‐corroborated asymmetric at poles. components showed its synchronous that replisome...

Abstract The reactions of hafnium isopropoxide isopropanolate with thio-Schiff bases (derived from the condensation S-methyldithiocarbazate aldehydes/ketones) in different molar ratios 1:n (n = 1 to 4) refluxing benzene have been carried out. products type, Hf(OPri)4-n(TSB)n and Hf(OPri)4–2n(TSB«)n or 2) ([TSB]− [TSB«]2- are anions mono- dibasic bases, respectively) were obtained characterized on basis elemental analyses, electrical conductance measurements spectral (infrared, electronic 1H...

The Yogic literatures are replete with examples of several unique mystical experiences in deeper states meditation. These have nevertheless remained largely untouched by the scientific community, possibly because extreme inexplicability such and lack sophistication evaluating them. More amenable to research, however, would seem be simpler awareness meditation as that inner light perception. While a few studies attempted explore this state objective means, subjective experience remains...