Breast cancer is the most prevalent among women in Greece. It crucial to have a simple, trustworthy and effective instrument for assessing factors that impact screening behaviors. This study aimed translate validate Greek version of Cancer Screening Beliefs Questionnaire (BCSBQ). In this cross-sectional methodological conducted from April June 2024, 202 aged 21 69 years participated using snowball sampling method. A backward-forward translation process was performed on BCSBQ. The evaluated...

Nasal irrigation is thought to decrease the viral load present in nasal cavity. Our aim was assess effect of a hypertonic seawater solution [with algal and herbal natural ingredients (Sinomarin®)] on nasopharynx patients hospitalized with severe COVID-19 pneumonia. We conducted prospective, randomized, controlled trial from June 2022 December 2022. allocated 56 pneumonia into two groups (28 each group)—the group [nasal irrigations (Sinomarin®) every 4 h for 16 per day, consecutive days]...

Summary B‐catenin is the central effector molecule of canonical Wnt signalling pathway, which controls self‐renewal haematopoietic stem cells. Deregulation this pathway occurs in various malignancies including myeloid leukaemias. The present study examined functional outcome stable β‐catenin down‐regulation through lentivirus‐mediated expression short hairpin RNA (shRNA). Reduction levels acute leukaemia (AML) cell lines and patient samples decelerated their vitro proliferation ability...

Background: Respiratory infections pose a major public health threat. The predominant viruses causing viral respiratory are influenza A and B (Flu-A, Flu-B), coronaviruses, syncytial virus (RSV), adenovirus. This study aims to investigate the proportion of these cases via rapid antigen tests assess seasonal patterns. Methods: Clinical samples were collected from symptomatic adults presenting Emergency Medicine Departments University Hospital Larissa (UHL), Greece 16 October 2023 31 March...

To clarify the role of ADAMTS-13 in pathogenesis thrombotic microangiopathy systemic lupus erythematosus (SLE) we evaluated profile (metalloprotease antigen levels, anti-ADAMTS-13 autoantibody activity) distinct patient groups according to disease activity, extent cumulative tissue damage and history antiphospholipid syndrome or end-organ damage. Forty-one patients were analysed. metalloprotease levels autoantibodies by ELISA. activity was measured Fluorescence resonance energy transfer...

Abstract Malignant pleural mesothelioma (MPM) is an aggressive tumour that grows in the cavity. MPM spheroids released fluid can form new foci. Cell–cell, cell–extracellular matrix (ECM) interactions 2D and 3D impact malignant cell behaviour during adhesion, migration, proliferation epithelial–mesenchymal transition (EMT). In this study, epithelioid, biphasic sarcomatoid types as well benign mesothelial cells were tested with regards to above phenotypes. Fibronectin (FN) homologous...

CD44 has been linked to favorable prognosis in neuroblastoma and the present study we investigate if it can be used prospectively isolate neuroblastoma-initiating cells. To define cancer-initiating properties of positive negative cells, FACS-sorted SK-N-SH cell line on basis expression proceeded phenotypically molecularly characterize two subpopulations. We found that defines morphologically distinctive populations with different adhesion molecule profiles, cells expressed higher levels...

Background: Features of post-traumatic stress disorder and anxiety may be present in Pulmonary Embolism (PE) patients along with impaired Quality Life (QoL). We aim to evaluate health related QoL, satisfaction life, during the pandemic, a PE. Methods: Patients PE were enrolled their follow-up. All participants completed Short Form 36 (SF-36) questionnaire, State Trait Anxiety Inventory (STAI) X1 X2 form, Satisfaction Scale (SWLS). Results: 92 included (mean age±SD=62.50±15.33 years, 56.5%...

Features of post-traumatic stress disorder and anxiety may be present in pulmonary embolism (PE) patients, along with impaired quality life (QoL). We aim to evaluate health-related QoL, satisfaction patients PE. Patients PE were enrolled during their follow-up. All participants completed the Short Form 36 (SF-36) questionnaire, State-Trait Anxiety Inventory (STAI) X1 X2 forms, Satisfaction Life Scale (SWLS). 92 included (mean age ± SD = 62.50 15.33 years, 56.5% males). The median values...

Only one study has reported the presence of extracellular vesicles (EVs) in COPD patients' sputum. Thus, we aimed to isolate and characterize EVs from healthy individuals'

Although great progress has been made over the past 2 years in scientific understanding of biology, epidemiology, and pathogenesis severe acute respiratory syndrome coronavirus (SARS-CoV-2), case morbidity fatality rates remain a concern continue to challenge healthcare resources worldwide as novel variants emerge. There is therefore an urgent need for affordable readily available strategies reduce viral transmission. Previous studies non-COVID-19 patients have demonstrated that...

Background and objectives: Malignant pleural mesothelioma (MPM) is a devastating malignancy with poor prognosis. Reliable biomarkers for MPM diagnosis, monitoring, prognosis are needed. The aim of this study was to identify genes associated wound healing processes whose expression could serve as prognostic factor in patients. Materials Methods: We used data mining techniques transcriptomic analysis so assess the differential transcriptional wound-healing-associated MPM. Moreover, we...

Oligoarticular juvenile idiopathic arthritis (oligo-JIA) is considered as an antigen-driven lymphocyte-mediated autoimmune disease. Natural antibodies (NAbs) are pre-immune produced in the absence of exogenous antigen stimulation, participating both, innate and adaptive immunity. Considering their major immunoregulatory role homeostasis pathogenesis, we designed this study to further elucidate oligo-JIA pathogenesis.Seventy children with persistent 20 healthy matched controls were enrolled...

Malignant pleural mesothelioma (MPM), a rare and aggressive tumor, has significant histological molecular heterogeneity. Primary Cilium (PC), an organelle of emerging importance in malignancies, been scarcely investigated MPM. A critical complex for the PC function is BBSome here we aimed at assessing its expression patterns ordinary 2D spheroid 3D cell cultures. human benign mesothelial line (MeT-5A), MPM lines (M14K, epithelioid MPM; MSTO, biphasic MPM), primary cells (pMPM) were used....

Background: SARS-CoV-2 vaccines have shown high efficacy in protecting against COVID-19, although the determinants of vaccine effectiveness and breakthrough rates are yet to be determined. We aimed at investigating several factors affecting IgG Spike (S) antibody responses on admission clinical outcomes COVID-19 disease fully vaccinated, hospitalized patients. Methods: 102 subjects were enrolled study. Blood serum samples collected from each patient upon for semiquantitative determination S...

The reported cases of pertussis vary considerably globally. In the present nationwide study, we aimed to record Bordetella prevalence in Greece by measuring serum IgG specific antibody levels toxin (anti-PT IgG). General practitioners and laboratories participated this study from 12 regions Greece. A geographically stratified sampling plan based on regional units (NUTS level 2) was applied order produce a representative sample, taking into consideration age group (30–39, 40–49, 50–59, 60–69,...

Human Herpesviruses (HHVs) maintain life-long latent persistence in the majority of adult population including blood donors. The necessity for their study resides potential risk transfusion-associated infection and subsequent complications immunocompromised host. We aimed to assess prevalence HHVs types 1-6 8 among healthy donors Thessaly prefecture order evaluate frequency distribution Greek ascertain possible correlations with demographic factors.Polymerase chain reaction (PCR) detection...

The purpose of this study was to assess the correlation previous bladder cancer history with recurrence and progression patients high-risk non-muscle-invasive treated adjuvant Bacillus Calmette-Guérin (BCG) evaluate their natural history.Patients were divided into two groups based on existence (primary, non-primary). A logistic regression analysis used identify possible differences in probabilities respect tumor history, while potential due gender, size (> 3 cm, < cm), stage (pTa, T1),...