A5069457592- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Acute Myeloid Leukemia Research
- Eosinophilic Disorders and Syndromes
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Erythropoietin and Anemia Treatment
- Eosinophilic Esophagitis
- Complement system in diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Liver Disease and Transplantation
- Gastroesophageal reflux and treatments
- Urticaria and Related Conditions
- Tuberculosis Research and Epidemiology
- Parvovirus B19 Infection Studies
- Hematological disorders and diagnostics
- Blood Coagulation and Thrombosis Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Veterinary medicine and infectious diseases
- Mycobacterium research and diagnosis
- Systemic Lupus Erythematosus Research
- Gastrointestinal disorders and treatments
- Immunodeficiency and Autoimmune Disorders
Aristotle University of Thessaloniki
2013-2025
Hippocration General Hospital
2011-2024
Ippokrateio General Hospital of Thessaloniki
2010-2022
Background/Objectives: B-thalassemia is a genetic disorder that leads to reduced or absent β-globin chains, often resulting in endocrine abnormalities due iron overload, chronic anemia, and hypoxia. This study investigates the prevalence risk factors for glucose metabolism disturbances transfusion-dependent β-thalassemia (TDT) patients, focusing on pancreatic overload its association with other biomarkers. Methods: We studied two groups of TDT patients (2018–2022) at Hippokration General...
The assessment of health-related quality life (HRQoL) in thalassemia offers a holistic approach to the disease and facilitates better communication between physicians patients. This study aimed evaluate HRQoL transfusion-dependent (TDT) patients Greece. was multicentric, cross-sectional conducted 2017 involving 283 adult TDT All participants completed set two QoL questionnaires, generic SF-36v2 disease-specific TranQol. Demographic clinical characteristics were used predefine patient...
The use of rivaroxaban in patients with hemoglobinopathies and thrombotic events has not been studied extensively. Here we present eight cases such patients, five receiving for stroke systemic embolism prevention due to non-valvular atrial fibrillation three deep vein thrombosis treatment. follow-up period ranged from 6 34 months. During this none the experienced any or bleeding event.There were no other adverse reported. Further studies larger numbers are needed determine ensure its safety...
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are essential weapons to control the spread of disease-19 (COVID-19) pandemic and protect immunocompromised patients. With a greater susceptibility infection, sickle cell disease (SCD) patients considered as "high risk" during current COVID-19 pandemic. In our study, we try determine immune response adult SCD monitored at center after first second dose qualified mRNA vaccines available correlate them several...
To clarify the role of ADAMTS-13 in pathogenesis thrombotic microangiopathy systemic lupus erythematosus (SLE) we evaluated profile (metalloprotease antigen levels, anti-ADAMTS-13 autoantibody activity) distinct patient groups according to disease activity, extent cumulative tissue damage and history antiphospholipid syndrome or end-organ damage. Forty-one patients were analysed. metalloprotease levels autoantibodies by ELISA. activity was measured Fluorescence resonance energy transfer...
We report a case of bone marrow aspiration and trephine biopsy (BMATB) associated haematoma in an 85-years old male without any predisposing risk factors. Six days after BMATB, he suffered from massive thigh buttock fall haematocrit. It is important to know that BMATB can have complications aiding early recognition therapy.
Immune thrombocytopenia (ITP) in adults is an acquired chronic immune-mediated disorder defined by isolated thrombocytopenia. In recent years, improved understanding of the pathophysiology ITP has been achieved and it now accepted that due to increased platelet destruction decreased production from megakary-ocytes. Thrombopoietin (TPO)-receptor agonists (romiplostim eltrombopag) are new therapeutic modalities treatment ITP. Here we describe a case elderly patient with severe who presented...
<i>Background/Aims/Methods:</i> To determine the frequency of <i>Helicobacter pylori</i> infection (<i>Hp</i>-I) in 73 patients with myelodysplastic syndromes (MDS) and 40 controls, serologic analyses <i>Hp</i> <sup>13</sup>C-urease breath tests (INFAI) were performed. Gastric mucosal biopsy specimens obtained to presence <i>Hp</i>-I using a rapid urease test, i.e. Campylobacter-like organism (CLO) cresyl violet...
Abstract Background Parental history of coronary artery disease (CAD) is considered an important risk factor for early atherosclerosis Hypothesis The onset the inflammatory process initiates during childhood in children with positive family (PFH) CAD. Methods We studied 55 healthy (5–15 years), 30 (16 male) PFH and 25 age sex matched control subjects. Blood samples were taken to measure white blood count (WBC), glucose, total cholesterol, triglycerides (TG), high‐density lipoprotein (HDL),...
Sickle cell disease (SCD) results from mutations in the β-globin gene, producing abnormal hemoglobin S (HbS) and leading to complications causing significant morbidity mortality.1 One of hallmark consequences SCD is occurrence vaso-occlusive crises (VOCs), which arise interplay factors disease's pathophysiology, involving polymerization, inflammation, endothelial dysfunction, activation immune system, culminating painful obstruction blood vessels by sickled red cells, that tend obstruct...
Myocardial siderosis in β-thalassemia major (β-TM) remains the leading cause of death. Deferasirox (DFX), a new iron chelation treatment, has proved to be effective reducing or preventing cardiac burden thalassemic patients according clinical trials with maximum duration up 3 years except one that was recently published and lasted 5 years. The aim this study evaluate efficacy DFX 23 β-TM after therapy. All had magnetic resonance imaging (MRI) T2* evaluation their load before starting therapy...
Review Articles| September 21 2011 Safety and Efficacy of Combination Therapy with Pegylated Interferon Alpha-2a Ribavirin in Treating Patients Chronic Hepatitis C Beta-Thalassaemia Major: A Greek Single-Center Experience Subject Area: Hematology , Oncology Paschalis Paschos; Paschos Second Medical Department, Aristotle University, Search for other works by this author on: This Site PubMed Google Scholar Efthimia Vlachaki; Vlachaki Thalassaemia Unit, Ippokratio Hospital, Thessaloniki, Greece...
Extramedullary hematopoiesis (EMH) results from the extension of hematopoietic tissue beyond confines bones. Since initiation regular transfusion programs an early age for all thalassemia major (&#x03A4;&#x039C;) patients, EMH has not been considered a clinical issue anymore. The present study aims to record prevalence in chronically transfused &#x03A4;&#x039C; patients followed at our institution and investigate possible risk factors associated with its occurrence. project...
We herein report a case of thalassemic-patient who was on deferasirox chelation therapy and admitted to the emergency department because fever, diffuse abdominal pain altered mental status. Despite appropriate treatment he died two days later due cardiac arrest. As we failed recognize any etiology patients’ relatives denied post mortem examination religious reasons, cannot provide additional data. However, are wondering whether this incident might be related deferasirox.
Healthcare systems around the globe are still facing evolving threat of coronavavirus-19 (COVID-19) pandemic. Hemoglobinopathies include a group genetic disorders, with two main entities being thalassemias and sickle cell disease. Due to their immunocompromised status, such patients have been protected as extremely vulnerable COVID-19 infection. We studied different hemoglobinopathies, consecutively monitored at our center, who were infected severe acute respiratory syndrome coronavirus 2...