Melanie Warren

ORCID: 0000-0003-2893-9063
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About
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Research Areas
  • CAR-T cell therapy research
  • Virus-based gene therapy research
  • IL-33, ST2, and ILC Pathways
  • Sarcoma Diagnosis and Treatment
  • Ichthyology and Marine Biology
  • Fish Biology and Ecology Studies
  • Tumors and Oncological Cases
  • Identification and Quantification in Food
  • Marine Ecology and Invasive Species
  • Hemodynamic Monitoring and Therapy
  • Fish Ecology and Management Studies
  • Genomics and Phylogenetic Studies
  • Aquaculture Nutrition and Growth
  • Cardiac pacing and defibrillation studies
  • Water Quality and Pollution Assessment
  • Fish biology, ecology, and behavior
  • Renal function and acid-base balance
  • Histone Deacetylase Inhibitors Research
  • Flood Risk Assessment and Management
  • Urban Stormwater Management Solutions
  • Aquatic life and conservation

University of British Columbia
2022-2024

University of Colorado Boulder
2023

Texas A&M Health Science Center
2018

Houston Museum of Natural Science
2013

Louisiana State University
2013

An improved and expanded nomenclature for genetic sequences is introduced that corresponds with a ranking of the reliability taxonomic identification source specimens. This an advancement "Genetypes" naming system, which some have been reluctant to adopt because use "type" suffix in terminology. In new nomenclature, are labeled "genseq," followed by (e.g., 1 if sequence from primary type), name genes were derived genseq-1 16S, COI). The numbered provides indication likely voucher. Included...

10.3897/zookeys.346.5753 article EN cc-by ZooKeys 2013-11-01

This study presents new records of three Critically Endangered angel shark species (Family: Squatinidae) occurring in the Eastern Mediterranean—Smoothback Angelshark S. oculata Bonaye, 1840, Sawback aculeata Cuvier, 1829, and squatina (Linnaeus, 1758). The supporting data serves to highlight potential Critical Angel Shark Areas (CASAs) Türkiye: Fethiye Bay, Çanakkale Strait (i.e., Dardanelles), Antalya Bay. These also demonstrate that female may mature at a smaller size than prior published...

10.3390/fishes9070270 article EN cc-by Fishes 2024-07-08

Alveolar rhabdomyosarcoma (ARMS) patients have a poor prognosis, and this is primarily due to overexpression of the oncogenic fusion protein PAX3-FOXO1. Results RNA-sequencing studies show that PAX3-FOXO1 represses expression interleukin-24 (IL24), these two genes are inversely expressed in patient tumors. also regulates histone deacetylase 5 (HDAC5) ARMS cells, results RNA interference confirmed PAX3-FOXO1-mediated repression IL24 HDAC5-dependent. Knockdown decreases cell proliferation,...

10.1158/1535-7163.mct-18-0118 article EN Molecular Cancer Therapeutics 2018-09-06

Extreme weather events can adversely impact potable water production and distribution, which could in turn have public health implications. The original study goal was to assess potential quality hazards (both chemical microbiological) the aftermath of Hurricane Maria, made landfall Puerto Rico on September 20, 2017. first sampling campaign surveyed sources that were contextually relevant disaster recovery included government-managed systems, community-managed unmanaged/improvised (spring)...

10.1021/acsestwater.2c00425 article EN ACS ES&T Water 2023-01-24

The length–weight relationships (LWR) of the common seadragon Phyllopteryx taeniolatus (Lacepède, 1804) and leafy Phycodurus eques (Günther, 1865), Syngnathidae, are presented in this paper, based on specimens raised Birch Aquarium at Scripps, La Jolla, California. Furthermore, we used length known age 40 15 seadragons to estimate parameter von Bertalanffy growth function (VBGF) for these species. Some pros cons newly proposed type used, ‘scalene length’ presented. parameters LWR VBGF...

10.3390/fishes7020077 article EN cc-by Fishes 2022-03-31

<p>(A) IPA analysis of pathways observed after knockdown PAX3-FOXO1 in Rh30 cells. (B.) Knockdown NR4A1 ARMS cells by a second oligonucleotide targeting NR4A1.</p>

10.1158/1535-7163.22509876.v1 preprint EN cc-by 2023-04-03

<p>(A) IPA analysis of pathways observed after knockdown PAX3-FOXO1 in Rh30 cells. (B.) Knockdown NR4A1 ARMS cells by a second oligonucleotide targeting NR4A1.</p>

10.1158/1535-7163.22509876 preprint EN cc-by 2023-04-03

<div>Abstract<p>Alveolar rhabdomyosarcoma (ARMS) patients have a poor prognosis, and this is primarily due to overexpression of the oncogenic fusion protein PAX3-FOXO1. Results RNA-sequencing studies show that PAX3-FOXO1 represses expression interleukin-24 (IL24), these two genes are inversely expressed in patient tumors. also regulates histone deacetylase 5 (HDAC5) ARMS cells, results RNA interference confirmed PAX3-FOXO1–mediated repression IL24 HDAC5-dependent. Knockdown...

10.1158/1535-7163.c.6539421 preprint EN 2023-04-03

<div>Abstract<p>Alveolar rhabdomyosarcoma (ARMS) patients have a poor prognosis, and this is primarily due to overexpression of the oncogenic fusion protein PAX3-FOXO1. Results RNA-sequencing studies show that PAX3-FOXO1 represses expression interleukin-24 (IL24), these two genes are inversely expressed in patient tumors. also regulates histone deacetylase 5 (HDAC5) ARMS cells, results RNA interference confirmed PAX3-FOXO1–mediated repression IL24 HDAC5-dependent. Knockdown...

10.1158/1535-7163.c.6539421.v1 preprint EN 2023-04-03
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