A5101623929- Developmental Biology and Gene Regulation
- Animal Genetics and Reproduction
- Invertebrate Immune Response Mechanisms
- RNA Research and Splicing
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer-related molecular mechanisms research
- Phosphodiesterase function and regulation
- Prenatal Screening and Diagnostics
- Neuropeptides and Animal Physiology
- Marine and coastal plant biology
- Adipose Tissue and Metabolism
- Microtubule and mitosis dynamics
- Peroxisome Proliferator-Activated Receptors
- Metabolism, Diabetes, and Cancer
- Chemokine receptors and signaling
- Hedgehog Signaling Pathway Studies
- Chromosomal and Genetic Variations
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Shandong University
2020
Center for Life Sciences
2015-2019
Tsinghua University
2014-2019
The piRNA pathway plays an important role in maintaining genome stability the germ line by silencing transposable elements (TEs) from fly to mammals. As a highly conserved component, Piwi is widely expressed both cells and somatic Drosophila ovary required for production cell types. In addition its known cap maintain germline stem (GSCs), this study has demonstrated that novel functions of promote differentiation. knockdown escort causes reduction (EC) number accumulation undifferentiated...
Adult stem cells continuously undergo self-renewal and generate differentiated cells. In the Drosophila ovary, two separate niches control germ line cell (GSC) differentiation processes. Compared to self-renewing niche, relatively little is known about maintenance function of niche. this study, we show that cellular redox state regulated by Wnt signaling critical for niche promote GSC progeny differentiation. Defective causes loss upregulated BMP in progeny, thereby disrupting...
Both stem cell self-renewal and lineage differentiation are controlled extrinsically as well intrinsically. Germline cells (GSCs) in the Drosophila ovary provide an attractive model which to study both at molecular cellular level. Recently, we have proposed that escort (ECs) form a niche control GSC specification extrinsically. However, it remains poorly understood how maintenance function of regulated Here, this reveals new role COP9 modulate autocrine Hedgehog (Hh) signaling, thereby...
As a worldwide health issue, obesity is associated with the infiltration of monocytes/macrophages into adipose tissue causing unresolved inflammation. Monocyte chemoattractant protein-1 (MCP-1) exerts crucial effect on obesity-related infiltration. Clinically, aspirin and salsalate are beneficial for treatment metabolic diseases in which inflammation plays an essential role. Herein, we investigated precise mechanism their active metabolite salicylate TNF-α-elevated MCP-1 adipocytes. The...
Peroxisome proliferator-activated receptor gamma (PPAR gamma) plays an important role in the control of energy balance and lipid glucose homeostasis. Different transcript variants were investigated not only human but also other vertebrates. To look into evolutionary changes these variants, we analyzed genomic sequences PPAR genes from several vertebrate species, as well their mRNA EST data. Several potential alternative splicing exons at 5'-end gene identified. The is discovered to be...