A5070717541- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Eosinophilic Esophagitis
- Immune Response and Inflammation
- interferon and immune responses
- T-cell and Retrovirus Studies
Otto-von-Guericke University Magdeburg
2019-2022
Helmholtz Centre for Infection Research
2019-2021
Immune Regulation (United Kingdom)
2021
Cerebral infections are restrained by a complex interplay of tissue-resident and recruited peripheral immune cells. Whether innate lymphoid cells (ILCs) involved in the orchestration neuroinflammatory dynamics is not fully understood. Here, we demonstrate that ILCs accumulate cerebral parenchyma, choroid plexus, meninges onset Toxoplasma gondii infection. Antibody-mediated depletion conventional natural killer (cNK) ILC1s early stage infection results diminished cytokine chemokine expression...
Vaccination is the most efficient strategy to protect from infectious diseases and induction of a protective immune response not only depends on nature antigen, but also influenced by vaccination co-administration adjuvants. Therefore, precise monitoring adjuvant candidates their modulatory properties crucial step in vaccine development. Here, one central aspect appropriate humoral cellular effector mechanisms. In our study we performed direct comparison two promising development, STING...
Abstract The survival of peripheral T cells is dependent on their access to LNs (pLNs) and stimulation by IL‐7. In pLNs fibroblastic reticular (FRCs) lymphatic endothelial (LECs) produce IL‐7 suggesting contribution the IL‐7‐dependent cells. However, production detectable in multiple organs not restricted pLNs. This raises question whether pLN‐derived required for maintenance cell homeostasis. Here, we show that numbers naive (T N ) remain unaffected spleen mice lacking Il7 gene activity pLN...
Abstract NKp46 + innate lymphoid cells (ILC) modulate tissue homeostasis and anti-microbial immune responses. ILC development function are regulated by cytokines such as Interleukin (IL)−7 IL-15. However, the ILC-intrinsic pathways translating cytokine signals into developmental programs largely unknown. Here we show that anti-apoptotic molecule cellular FLICE-like inhibitory protein (c-FLIP) is crucial for generation of IL-7/IL-15-dependent ILC1, including conventional natural killer (cNK)...
In lymphopenic mice, T cells become activated and undergo lymphopenia-induced proliferation (LIP). However, not all are equally sensitive to lymphopenia. Several lymphopenia-insensitive cell clones were described their non-responsiveness was mainly attributed clone-specific properties. Here, we provide evidence for an additional, host-dependent mechanism restraining LIP of CD4+ cells. We show that such in mice lacking IFN-γ receptor (IFN-γR) expression, a process, which is promoted by the...
Targeted antigen delivery to cross-presenting dendritic cells (DC) in vivo efficiently induces T effector cell responses and displays a valuable approach vaccine design. Antigen is delivered DC via antibodies specific for endocytosis receptors such as DEC-205 that induce uptake, processing, MHC class I- II-presentation. Efficient reliable conjugation of the desired suitable antibody critical step targeting among other factors depends on format antigen. Chemical full-length protein purified...
Targeted antigen delivery to cross-presenting dendritic cells (DC) in vivo efficiently induces T effector cell responses and displays a valuable approach vaccine design. Antigen is delivered DC via antibodies specific for endocytosis receptors such as DEC-205 that induce uptake, processing, MHC class I- II-presentation. Efficient reliable conjugation of the desired suitable antibody critical step targeting among other factors depends on format antigen. Chemical full-length protein purified...
CD8+ memory T cells (TM ) are crucial for long-term protection from infections and cancer. Multiple cell types cytokines involved in the regulation of responses subsequent TM formation. Besides their direct antiviral effects, type I interferons (IFN-I) modulate immunity via action on several immune subsets. However, it is largely unclear how nonimmune this multicellular network modulating Fibroblastic reticular (FRCs) form 3D scaffold secondary lymphoid organs, express IFN-I receptor...