A5019993344- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Hepatocellular Carcinoma Treatment and Prognosis
- Blood properties and coagulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Dental Radiography and Imaging
- Flavonoids in Medical Research
- Dental Implant Techniques and Outcomes
- Viral Infectious Diseases and Gene Expression in Insects
- Oral microbiology and periodontitis research
- Dental materials and restorations
- Cancer Research and Treatments
- Connexins and lens biology
- Paraoxonase enzyme and polymorphisms
- Organ Transplantation Techniques and Outcomes
- Oral Health Pathology and Treatment
- Hepatitis B Virus Studies
- Dental Erosion and Treatment
- Medicinal Plants and Bioactive Compounds
- Bone and Dental Protein Studies
Taizhou Central Hospital
2011-2025
Taizhou University
2022-2025
Shanghai Medical College of Fudan University
1990-1993
Aberrant N7 -methylguanosine (m7G) levels closely correlate with tumor genesis and progression. NCBP2 EIF4E3 are two important m7G-related cap-binding genes. This study aimed to identify the relationship between EIF4E3/NCBP2 function immunological characteristics of head neck squamous cell carcinoma (HNSCC). Hierarchical clustering was employed in classifying HNSCC patients into groups based on expressions EIF4E3. The differentially expressed genes were identified groups, GO functional...
Abstract This study investigated the cancer‐promoting effect of ferroptosis regulator DNA damage‐inducible transcript 4 (DDIT4) and its relevant mechanisms. Vital ferroptosis‐related genes were identified using bioinformatic methods on basis data collected from TCGA seven other online databases. Cell Counting Kit‐8 (CCK8), colony formation, wound‐healing transwell assays, western blot analysis conducted for verifying biological role DDIT4 in vitro. The immune score tumor purity calculated R...
Chronic inflammation, immune cell infiltration, and metabolic reprogramming play a crucial role in the development of head neck squamous carcinoma (HNSCC). Based on summary-level data from genome-wide association study (GWAS), this used Mendelian randomization (MR) analysis to investigate causal relationship between phenotype HNSCC. Two-step MR was employed quantify proportion effect metabolite-mediated immunophenotypes 16 phenotypes exhibited with HLA DR + CD4 AC (OR: 1.31, 95% CI...
Oral squamous cell carcinoma (OSCC) has increasingly become a worldwide health concern, and its survival rate not been much improved partially due to deficiency of precise molecular markers. Dysregulation LINC01116, long noncoding RNA sequence, observed in several types cancer. However, the role played by LINC01116 OSCC yet fully elaborated. This study explored how was involved regulation progression analyzing expressions patients. The findings demonstrated upregulation tissues as opposed...
Abstract Investigation on the effect of Piezo1 periodontal tissue and ligament fibroblasts (PDLFs) under mechanical stress underlying mechanism. The orthodontic tooth movement rat model was established via an spiral tension spring. PDLFs were cultured subjected to 2.0 g/cm 2 static compressive loading. Blocked inhibitor, GsMTx4. TUNEL staining flow cytometry determined apoptosis rate in rats. Expression Piezo1, p‐p38 ERK1/2 analysed by immunofluorescence assay western blotting. inhibitor...
Abnormal RNA N7-methylguanosine (m7G) modification is known to contribute effects on tumor occurrence and development. Nevertheless, the mechanisms of its function in immunoregulation, microenvironment (TME) modulation, promotion remain largely unknown. A series computer-aided bioinformatic analyses were conducted based transcriptomic, single-cell sequence, spatial transcriptomic data determine m7G patterns head neck squamous cell carcinoma (HNSCC). Consensus clustering approach was employed...
Salidroside modulates cell proliferation and serves as an anti-inflammatory anti-apoptotic agent with efficacy against various diseases. The objective of the present study was to investigate salidroside in enhancing human periodontal ligament cells (hPDLCs). hPDLCs were isolated effects on viability, soluble osteocalcin levels activation proliferation-associated signaling pathways determined using a CCK-8 assay, ELISA Western blotting, respectively. results indicated that induced hPDLCs,...
article: Clinical comparative study of ultrasonic subgingival scaling and combined with manual in the treatment chronic periodontitis - Minerva Surgery 2021 Dec 10 Medica Journals
Abstract Disulfidptosis is a newfound programmed cell death (PCD) mode characterized by disulfide stress. Several computer-aided bioinformatic analyses were performed to elucidate the characteristics and functional significance of disulfidptosis-related genes in head neck squamous carcinoma (HNSCC). The relative compositions cells tumor microenvironment (TME), mutant landscape, lasso regression analysis, predicted clinical outcome analyzing bulk RNA-sequence data. prognostic model was...
That Ito cells in rat liver express desmin was confirmed by immunohistochemical technique. Anyhow, changes of desmin-positive cells, lysozyme-positive and fibronectin were further studied experimental cirrhosis rat. It found that with the transitional features between myofibroblasts or fibroblasts under electron microscope, increased number expression necrotic areas as well cellular fibrous septa, but decreased septa except those close to edges septa. These results suggested may belong same...