A5032776801- Health Systems, Economic Evaluations, Quality of Life
- Healthcare cost, quality, practices
- Innovations in Medical Education
- Global Health Workforce Issues
- Global Health and Surgery
- Healthcare professionals’ stress and burnout
- Patient-Provider Communication in Healthcare
- CAR-T cell therapy research
- Health and Medical Research Impacts
- Perfectionism, Procrastination, Anxiety Studies
- Cancer Diagnosis and Treatment
- Viral Infections and Outbreaks Research
- Empathy and Medical Education
- COVID-19 Clinical Research Studies
- Bladder and Urothelial Cancer Treatments
- Healthcare Systems and Challenges
- Mental Health and Patient Involvement
- Radiology practices and education
- Smoking Behavior and Cessation
- Meta-analysis and systematic reviews
- Cannabis and Cannabinoid Research
- Medication Adherence and Compliance
- History of Medical Practice
- Mindfulness and Compassion Interventions
- Health Sciences Research and Education
Erasmus MC
2017-2025
Elisabeth-TweeSteden Ziekenhuis
2025
Haga Hospital
2025
Rotterdam University of Applied Sciences
2023-2025
Erasmus University Rotterdam
2021-2023
Netherlands Institute for Health Services Research
2023
BMJ Group (United Kingdom)
2019
Resilience training shows moderate effect in combatting burnout, yet little is known about its cost-effectiveness. This study analyzes the cost-effectiveness of offering resilience to medical students with elevated stress from a Dutch university center (payer) perspective compared mental health support as usual. We constructed state-transition cohort (Markov) model estimate quality-adjusted lifeyears and associated costs 410 first-year over 6-year timeframe. Utility values were obtained...
First-line treatment of diffuse large B-cell lymphoma (DLBCL) achieves durable remission in approximately 60% patients. In relapsed or refractory disease, only about 20% achieve with salvage chemoimmunotherapy and consolidative autologous stem cell transplantation (ASCT). The ZUMA-7 (axicabtagene ciloleucel [axi-cel]) TRANSFORM (lisocabtagene maraleucel [liso-cel]) trials demonstrated superior event-free survival (and, ZUMA-7, overall survival) primary-refractory early-relapsed (high-risk)...
Decision-analytic models (DAMs) are essentially informative yet complex tools for solving questions in medical decision making. When their complexity grows, the need causal inference techniques becomes evident as relationships between variables become unclear. In this methodological commentary, we argue that graphical representations of assumptions on such relationships, directed acyclic graphs (DAGs), can enhance transparency and aid parameter selection estimation through visually...
Importance Given the widespread use of medical imaging, evaluating effectiveness interventions to improve appropriateness is crucial for optimizing health care resources and patient outcomes. Objective To assess effects implementing a clinical decision support system (CDSS), European Society Radiology iGuide, on imaging ordering behavior physicians. Design Setting A cluster randomized trial with 26 departments at 3 German university hospitals acting as clusters, incorporating before after...
Abstract Introduction Medical educators aim to understand why students differ in performance and stress. While stress are associated with student demographics, school factors aspects of self‐regulated learning (SRL), it remains unclear how these elements interact within individuals. This multi‐cohort study identified SRL profiles among medical explored their associations Additionally, we examined the profiles' gender, migration status assessment policy. Methods We used latent profile...
Over 5.7 million people in Burundi—almost half of the total population—have been infected with malaria since start 2019.1 The ongoing epidemic has taken lives 1801 people, equalling death toll caused by Ebola neighbouring Democratic Republic Congo. Despite outbreak reaching proportions Burundi not yet declared a national emergency. This delay coincides country’s upcoming elections 2020. A senior government official said that president, Pierre Nkurunziza, fears such declaration would be...
The COVID-19 pandemic necessitates time-sensitive policy and implementation decisions regarding new therapies in the face of uncertainty. This study aimed to quantify consequences approving or pursuing further research: immediate approval, use only research, approval with research (eg, emergency authorization), reject.
Medical imaging plays an essential role in healthcare. As a diagnostic test, is prone to substantial overuse and potential overdiagnosis, with dire consequences patient outcomes health care costs. Clinical decision support systems (CDSSs) were developed guide referring physicians making appropriate decisions. This study will evaluate the effect of implementing CDSS (ESR iGuide) versus without active physician order entry on use tests ordering behaviour.
Abstract While frameworks to systematically assess bias in systematic reviews and meta-analyses (SRMAs) on causal inference are well established, they less frequently integrated beyond the data analysis stages. This paper proposes use of Directed Acyclic Graphs (DAGs) design stage SRMAs. We hypothesize that DAGs created registered a priori can offer useful approach more effective efficient evidence synthesis. provide visual representation complex assumed relationships between variables...
Faculty Development (FD) has become essential in shaping design, delivery and quality assurance of health professions education. The growth FD worldwide led to a heightened expectation for organizational integrity the programmes. To address this, AMEE, An International Association Health Professions Education, developed standards through development AMEE ASPIRE Excellence criteria. This guide uses criteria as framework educators who wish establish or expand approaches scholarship within...
The National Institute for Health and Care Excellence (NICE) has rejected cannabidiol treating two types of severe treatment resistant epilepsy in draft guidelines.12 The independent appraisal committee highlighted its concern that the evidence showing reduces main seizures associated with these conditions was based on clinical trials lasted just 14 weeks, leaving doubts about long term effectiveness. It said it would work GW Pharma, which makes Epidiolex, to deal issues raised by...
People with the inherited disease Lynch syndrome should be offered daily aspirin to reduce their risk of colorectal cancer, National Institute for Health and Care Excellence (NICE) has said in draft guidance.1 People have a 50-80% increased cancer,2 second leading cause cancer deaths UK. This is first time that NICE included advice about reducing among people syndrome, although …
7537 Background: The recently reported ZUMA-7 and TRANSFORM trials demonstrate superior event-free survival among patients with primary refractory or early relapsed DLBCL compared to salvage chemotherapy ASCT. However, given a cost of >$370,000, it is not known whether second-line CAR-T cost-effective Thus, we developed state-transition microsimulation model simulate clinical outcomes costs associated therapy for in first relapse, using data. Methods: begins at initiation comparing ASCT...
Background The COVID-19 pandemic underscored the criticality and complexity of decision making for novel treatment approval further research. Our study aims to assess potential decision-making methodologies, an evaluation vital refining future public health crisis responses. Methods We compared 4 approaches drug research: Food Drug Administration’s policy decisions, cumulative meta-analysis, a prospective value-of-information (VOI) approach (using information available at time decision),...
The aim of this study was to determine an optimal follow-up imaging surveillance strategy in terms cost-effectiveness after resection nonfunctioning pituitary adenomas with curative intent.An individual-level state-transition microsimulation model used simulate costs and outcomes associated three postoperative strategies over a lifetime time horizon: 1) annual MRI surveillance, 2) tapered (annual for 5 years followed by every 2 years), 3) personalized when shows remnant disease/postoperative...