Tuberculosis (TB) is the world’s deadliest infectious disease, with over 1.5 million deaths and 10 new cases reported anually. The causative organism Mycobacterium tuberculosis (Mtb) can take nearly 40 d to culture, a required step determine pathogen’s antibiotic susceptibility. Both rapid identification susceptibility testing of Mtb are essential for effective patient treatment combating antimicrobial resistance. Here, we demonstrate rapid, culture-free, incubation-free drug test TB using...

Prolonged exposure to aluminum through occupational hazards or food/water intake has been linked the occurrence of Alzheimer's disease (AD). This study aimed at investigating neuroprotective effects Gallic Acid (GA) against aluminum-chloride induced AD in adult Wistar rats. Twenty eight (28) rats were divided into four groups (n = 7). Group A received normal saline as placebo; B 200 mg/kg bw AlCl3 only; C 100 GA only and group D AlCl3. At end 60 days experiment, blood samples collected...

Although wastewater-based epidemiology has been used extensively for the surveillance of viral diseases, it not to a similar extent bacterial diseases. This is in part owing difficulties distinguishing pathogenic from nonpathogenic bacteria using PCR methods. Here, we show that surface-enhanced Raman spectroscopy (SERS) can be scalable, label-free method detection wastewater. We enhance signal wastewater plasmonic gold nanorods (AuNRs) electrostatically bind surface and confirm this binding...

Alcohol (ethanol) is presently reputed to the most cause of disease development in humans.The liver human organ that frequently challenged alcohol abuse by oral route a process involves generation reactive oxygen species.In this study we evaluated histology, oxidative stress and activities biomarker enzymes investigate capabilities polyphenolic antioxidant-rich Moringa oleifera Leaf Extract ameliorate derangement caused alcohol.Three groups Wistar rats were constructed for study; A control...

To determine the impact of walnut oil on nitrite-induced testicular toxicity in Sprague-Dawley (SD) rats. Available evidence suggests that contains high levels important unsaturated fatty acids including alpha-linolenic acid (ALA) and omega-3; nitrite is a reproductive toxicant causes loss germ cells seminiferous tubules generates oxidative stress testes, thus reducing sperm counts affecting morphology.This study included 24 male female adult SD The rats randomly assigned to Group A...

Polycystic ovarian syndrome (PCOS) is characterized by anovulation and hyperandrogenism symptoms. Caffeine popularly consumed it a legal psychoactive substance. This study evaluated the effect of excessive caffeine intake on utero-ovarian tissue in polycystic ovary rats. Twenty-four female rats randomized into group A control received 2 ml normal saline. Group B 4 mg/kg body weight (bwt) i.p estradiol valerate (EV) first day, C 100 bwt orally, D EV orally. The experiment lasted 30 days....

The exposure of male individual to environmental toxicant is regarded as a channel that results in reduced sperm counts and infertility.This study investigated the ameliorative response Sulforaphane (SFN) on Aluminum trichloride (AlCl 3 ) induced testicular toxicity adult Wistar rats.A total 32 rats (180-200 gm between 8-10 wk) were divided into four groups (n = 8/each). Group A) received distilled water orally placebo; B) 100 mg/kgbw AlCl only orally; C) SFN D) orally. After 28 days...

Colloidal single-walled carbon nanotubes (SWCNTs) offer a promising platform for the nanoscale engineering of molecular recognition. Optical sensors have been recently designed through modification noncovalent corona phases (CPs) SWCNTs phenomenon known as phase recognition (CoPhMoRe). In CoPhMoRe constructs, DNA CPs are great interest due to breadth design space and our ability control these molecules with sequence specificity at scale. Utilizing constructs metal ion sensing is natural...

In most underdeveloped and developing countries, the anthropometric dimensions of users are not deployed in classroom furniture design. This has severe health as well learning implications. The aim this study was to determine ergonomic suitability at Federal University Technology, Akure, Nigeria. 261 (133 males 128 females) randomly selected students participated study. Their measures were taken after fully explaining purpose procedure measurements obtaining an informed consent from each...

This study investigated the exposure of pyrethroids in development Alzheimer's type neurodegeneration by analyzing β- amyloid, tau and Glial Fibrillary Acidic Protein (GFAP) adult Wistar rats. Forty rats (130-150 g) both sexes were assigned into five groups (n = 8). Groups A-C treated with three different sub-lethal doses (75, 50 25%)of formulation diluted olive oil once/daily for 45 days, while D&E received distilled water respectively (as control groups). During treatments, physical...

Reproductive toxicity has been greatly linked with Highly Active Antiretroviral Therapy (HAART) use. This study investigated the effects of Moringa oleifera Leaf Extract (MOE) on HAART-induced testicular in adult male Wistar rats.Twenty rats (150-200 g) were assigned into four groups (n=5). Group A received distilled water; B (orally) 200 mg/kg BW HAART only; C and 100 MOE (low dose group) D 300 MOE. At end 28-day experiment, body weights measured; serum testis obtained subjected to hormone...

Tetrapleura tetraptera (TT) has been used as a spice, dietary supplement and medicine for various ailments. This study evaluate influence of extract on testis copulatory behavior in sexually mature male rats. Thirty-two sixty-four virgin female rats weighing 150–200 g were this study. Male randomly divided into four groups eight (n = 8) each. Group A: Control given 2 ml distilled water, group B, C D received 50, 300 700 mg/kg bwt TT 56 days through oral gavage. The fertility test. Testicular...

Death arising from hepato-renal related diseases is on the increase. Cyperus esculentus (CE) possesses antioxidants potentials. This study aim at investigating effect of sodium fluoride (NaF)-induced toxicity in rats. Twenty-four male rats weighting (10–12 weeks old, 200± 20 g) randomized into group A (control) received 1 ml normal saline; B administered 5 mg/kg bwt NaF; C 500 CE; D NaF and CE through gastric gavage for 30 days. Liver kidney histology, serum aspartate aminotransferase (AST),...

The aim of this study was to investigate the antioxidant effect aqueous Lawsonia inermis leaf extract on aluminum-induced oxidative stress and histology pituitary gland adult Wistar rats.Thirty-five male rats weighing between 100-196g 15 mice same weight range were included in study. extracts aluminum chloride (AlCl3) administered for a period three weeks five per group. subjects Group 1 (control) given pellets distilled water. 2 received 60mg/kg/d inermis. 3 0.5mg/kg/d AlCl3. 4 AlCl3...

Cisplatin (CN) is considered as a cytotoxic agent and DNA synthesis inhibitor. D-Ribose-l-Cysteine (DRLC) an active ingredient of riboceine, help cells to produce glutathione on body demand.Current study focused ameliorating potential fertility enhancing activities in cisplatin induced oligoasthenoteratozoospermia seminiferous epithelium degeneration.Sixty (60) male rats randomized into six groups ten (n = 10) each. Group A (control) received 2.0 ml distilled water, group B single dose 8...

(2021). Incidence of School Furniture Mismatch and Health Implications in Primary Children Akure, South-West Nigeria. Journal Occupational Therapy, Schools, & Early Intervention: Vol. 14, No. 1, pp. 90-102.

Zinc (Zn) has proven to play a key role in spermatogenesis. The present study focused on the nutritional supplementation of Zn against cisplatin (CP)-induced spermatogonial and testicular dysfunctions. Thirty-two (32) mature male Sprague Dawley rats were randomized into four groups eight (n = 8) each – Control group (received 2 ml normal saline); 1 mg/kg body weight (bwt) sulfate); Cisplatin treated intraperitoneally with single dose (10 bwt) CP; CP + group, after induction toxicity,...

Graphical abstract Abstract Di-2-ethylhexyl phthalate (DEHP) is an extensively used plasticizer which has raised some concerns about its safety on human health. This study aimed at evaluating the effects of vanillic acid (VA) and vitamin C (VC) supplementation DEHP-induced testicular toxicity. Thirty-five adult male Wistar rats were randomly divided into 7 groups (A–G) ( n = 5 ) receiving distilled water; 250 mg/kg bw DEHP only; 30 VA DEHP; VC plus VC; only, respectively. At end experiment,...