A5036756445- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Effects of Radiation Exposure
- Cell Adhesion Molecules Research
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related Molecular Pathways
- Chemokine receptors and signaling
- DNA Repair Mechanisms
- Nuclear Structure and Function
- Fibroblast Growth Factor Research
- Cytokine Signaling Pathways and Interactions
- Anesthesia and Neurotoxicity Research
- Advanced Glycation End Products research
- Genetics, Aging, and Longevity in Model Organisms
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- interferon and immune responses
- Cellular Mechanics and Interactions
- Neonatal Respiratory Health Research
- Nanoplatforms for cancer theranostics
- Advanced Breast Cancer Therapies
- Melanoma and MAPK Pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Immunotherapy and Biomarkers
- Endoplasmic Reticulum Stress and Disease
Korea Institute of Radiological and Medical Sciences
2015-2024
Ewha Womans University
2012-2020
Korea Research Institute of Chemical Technology
2019
Sogang University
2018
Daejeon Health Institute of Technology
2018
Ewha Womans University Medical Center
2013
Objective: Tumor-treating fields are currently used to successfully treat various cancers; however, the specific pathways associated with its efficacy remain unknown in immune responses. Here, we evaluated tumor-treating fields–mediated initiation of macrophage-specific response. Materials and Methods: We subjected RAW 264.7 mouse macrophages clinically relevant levels (0.9 V/cm, 150 kHz) alterations cytokine expression release, as well cell viability. Additionally, investigated status...
Numerous studies have attempted to develop biological markers for the response radiation broad and straightforward application in field of radiation. Based on a public database, present study selected several molecules involved DNA damage repair response, cell cycle regulation cytokine signaling as promising candidates low‑dose radiation‑sensitive markers. The HuT 78 IM‑9 lines were irradiated concentration‑dependent manner, expression these was analyzed using western blot analysis. Notably,...
In contrast to high-dose therapeutic irradiation, definitive research detailing the physiological effects of low-dose irradiation is limited. Notably, immunological response elicited after remains controversial.Female C57BL/6 mice were whole- body-irradiated with a single or three daily fractions up total dose 0.1, 1, 10 cGy. Blood and spleen harvested 2, 7 14 days irradiation.The splenic CD4(+) T cell subpopulations temporarily increased at 2 fractionated whereas percentage dendritic cells...
Our previous work demonstrated that (E)-N-benzyl-6-(2-(3, 4-dihydroxybenzylidene) hydrazinyl)-N-methylpyridine-3-sulfonamide (BHMPS), a novel synthetic inhibitor of Rab27aSlp(s) interaction, suppresses tumor cell invasion and metastasis. Here, we aimed to further investigate the mechanisms action biological significance BHMPS. BHMPS decreased expression epithelial-mesenchymal transition transcription factors through inhibition focal adhesion kinase c-Jun N-terminal activation, thereby...
Glutaminyl cyclases (QC, isoQC) convert N-terminal glutamine or glutamate into pyroglutamate (pGlu) on substrates. IsoQC has recently been demonstrated to promote pGlu formation the N-terminus of CD47, SIRPα binding site, contributing "don't eat me" cancer immune signaling CD47-SIRPα. We developed new QC inhibitors by applying a structure-based optimization approach starting from fragments identified through library screening. Screening metal 5-(1H-benzimidazol-5-yl)-1,3,4-thiadiazol-2-amine...
Abstract Pulmonary fibrosis (PF) is chronic and irreversible damage to the lung characterized by fibroblast activation matrix deposition. Although recently approved novel anti‐fibrotic agents can improve function survival of patients with PF, overall outcomes remain poor. In this study, a imidazopurine compound, 3‐(2‐chloro‐6‐fluorobenzyl)‐1,6,7‐trimethyl‐1H‐imidazo[2,1‐ f ]purine‐2,4(3 H ,8 )‐dione (IM‐1918), markedly inhibited transforming growth factor (TGF)‐β‐stimulated reporter activity...
Ionizing radiation (IR) has been widely used in the treatment of cancer. Radiation-induced DNA damage triggers response (DDR), which can confer radioresistance and early local recurrence by activating repair pathways. Since karyopherin-α2 (KPNA2), playing an important role nucleocytoplasmic transport, was significantly increased IR our previous study, we aimed to determine function KPNA2 with regard DDR. Exposure upregulated expression human colorectal cancer HT29 HCT116 cells breast...
Radiotherapy is one of the most common treatments for cancer, but radioresistance and injury to normal tissue are considered major obstacles successful radiotherapy. Thus, there an urgent need develop radiosensitizers improve therapeutic outcomes radiotherapy in cancer patients. Our previous efforts identify novel radiosensitizers, using high-throughput screening targeting p53 Nrf2 revealed a promising <i>N</i>-phenylpyrimidin-2-amine (PPA) lead compound. In present study, 17 derivatives...
Low-dose irradiation (LDI) has recently been shown to have various beneficial effects on human health, such as cellular metabolic activities, DNA repair, antioxidant activity, homeostasis potency, and immune activation. Although studies the immunogenic of LDI are rapidly accumulating, clinical trials for cancer treatment considered premature owing lack available preclinical results protocols. Here, we aim investigate anti-tumor anti-metastatic whole-body in several tumor-bearing mouse...
Focal adhesion kinase 1 (FAK1) is known to promote tumor progression and metastasis by controlling cell movement, invasion, survival the epithelial-to-mesenchymal transition in microenvironment. As recent reports imply that FAK1 highly associated with development malignancy, inhibition of activity could be an effective therapeutic approach for inhibiting growth cells. In this study, we aimed determine effect a novel synthetic inhibitor...
is a nematode-specific gene that encodes type II transmembrane protein containing the BRICHOS domain. The was isolated as heat-sensitive mutant, but function of remained unclear. We examined expression pattern and subcellular localization C09F5.1 well its roles in thermotolerance chaperone function. Expression