A5064955085- Systemic Sclerosis and Related Diseases
- Eosinophilic Esophagitis
- Eosinophilic Disorders and Syndromes
- Mast cells and histamine
- Dysphagia Assessment and Management
- Inflammatory Myopathies and Dermatomyositis
- Vasculitis and related conditions
- Gastroesophageal reflux and treatments
- Urticaria and Related Conditions
- Systemic Lupus Erythematosus Research
- Musculoskeletal pain and rehabilitation
- Magnetic and Electromagnetic Effects
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Pelvic floor disorders treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Salivary Gland Disorders and Functions
- Esophageal Cancer Research and Treatment
- Dermatologic Treatments and Research
- Esophageal and GI Pathology
- Cardiovascular Effects of Exercise
- Anesthesia and Pain Management
- Whipple's Disease and Interleukins
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Breastfeeding Practices and Influences
Mayo Clinic in Arizona
2006-2021
Center for Rheumatology
1980-2019
Mayo Clinic
1990-1999
Abstract Objective Glucocorticoid (GC) therapy for giant cell arteritis (GCA) is effective but requires prolonged administration, resulting in adverse side effects. The goal of the current study was to test hypothesis that induction treatment with high‐dose pulse intravenous (IV) methylprednisolone permits a shorter course therapy. Methods Twenty‐seven patients biopsy‐proven GCA were enrolled randomized, double‐blind, placebo‐controlled receive IV (15 mg/kg ideal body weight/day) or saline 3...
GERTZ, MORIE A. M.D.; KYLE, ROBERT GRIFFING, W. LEROY HUNDER, GENE G. M.D. Author Information
We describe 2 patients presenting with polyarthritis in whom the synovial fluid (1 patient) or tissue was positive for Tropheryma whippelii, Whipple's disease–associated bacillus, when examined by polymerase chain reaction (PCR) and DNA sequencing. Histopathologic findings were consistent articular disease of 1 patient other. In both patients, bowel mucosal specimens negative features histologic PCR methods. One T whippelii peripheral blood. Control from 40 other arthritides, including Lyme...
INTRODUCTION: Systemic sclerosis or scleroderma (SSc) is a chronic autoimmune disease that renders the esophagus prone to significant gastroesophageal reflux due impaired esophageal clearance and reduced lower sphincter pressure. The reported prevalence of Barrett's (BE) in women with SSc varies from 2% 37% derived older studies small sample sizes. We aimed assess BE large cohort SSc. METHODS: Women referred Mayo Clinic Arizona Rheumatology who completed esophagogastroduodenoscopy between...
Study Objectives: Scleroderma is associated with abnormal skin thickening, interstitial lung disease, pulmonary hypertension, and abnormalities of the upper airway.These changes can cause cardiopulmonary complications, potentially including sleep-disordered breathing.The objective this study to examine risk breathing in patients scleroderma.Methods: We retrospectively identified documented scleroderma.We abstracted data from their electronic health records, findings antibody tests, serial...
Systemic scleroderma/sclerosis (SSc) is an autoimmune connective tissue disease, which can lead to esophageal motor dysfunction and gastroesophageal reflux disease (GERD). Nocturnal GERD symptoms may be associated with sleep disturbances, in turn drastically affect well-being fatigue levels. We hypothesized that would poorer patients SSc. Rheumatologist established SSc completed the following questionnaires: UCLA scleroderma clinical trial consortium gastrointestinal tract instrument (GIT)...
Panniculitis is defined as inflammation of the subcutaneous tissue. Two well-known variants, morphea profunda (MP) and lupus erythematosus panniculitis (LEP), can be difficult to distinguish clinically histologically. MP typically affects legs, forearms, trunk characterized by a bound-down inflammatory plaque or nodule with an overlying brown-red color peau d'orange change.1Onajin O. Wieland C.N. Peters M.S. Lohse C.M. Lehman J.S. Clinicopathologic immunophenotypic features eosinophilic...
Purpose: Systemic sclerosis (SSc; scleroderma) is a connective tissue disorder which primarily affects women. While commonly involving the skin, 90% of patients with SSc suffer from GI involvement. It known that involvement have lower quality life (QoL) and, while impact upper symptoms on QoL in has been described, there little data presence and SSc, specifically pelvic floor symptoms. Our goal was to assess prevalence women evaluate their QoL. Methods: Women (n=132) attending an outpatient...
Purpose: Scleroderma esophagus is associated with fibrosis of smooth muscle consequent loss LES tone and peristalsis. Conventional esophageal manometry utilizes limited pressure sensors to characterize contractile patterns. HRM 36 closely spaced, solid-state provide a more detailed assessment topographical mapping function. has not been adequately described in scleroderma patients. We hypothesized that isocontour plots would enhance description clinically relevant abnormalities peristaltic...
INTRODUCTION: Scleroderma renders the esophagus prone to significant gastroesophageal reflux due impairment in esophageal clearance (aperistalsis lower third of esophagus) and reduced sphincter (LES) pressure. mainly affects women, whereas Barrett’s (BE) predominantly men. The reported prevalence BE women with scleroderma varies widely from 6% 37%, is derived older small studies. We aimed assess true a large cohort scleroderma. METHODS: Clinical data were collected two prospectively...