A5050735301- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Dysphagia Assessment and Management
- Esophageal Cancer Research and Treatment
- Cardiac Structural Anomalies and Repair
- Eosinophilic Disorders and Syndromes
- Gastrointestinal motility and disorders
- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Financial Reporting and Valuation Research
- Inflammatory Bowel Disease
- Hepatitis C virus research
- Gastrointestinal disorders and treatments
- Healthcare Systems and Reforms
- Potassium and Related Disorders
- Respiratory and Cough-Related Research
- Cardiovascular Function and Risk Factors
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Iron Metabolism and Disorders
- Cardiomyopathy and Myosin Studies
- Renal Transplantation Outcomes and Treatments
- Pericarditis and Cardiac Tamponade
Duke University
2016-2025
Durham VA Medical Center
2016-2024
Duke Medical Center
2023-2024
St. Vincent Hospital
2021-2024
Saint Vincent's Catholic Medical Center
2023
St. Vincent's Birmingham
2023
University of Kentucky
2023
Queen Elizabeth University Hospital
2021-2022
Oxford Health NHS Foundation Trust
2022
University of Oxford
2022
Esophageal symptoms are common and may indicate the presence of gastroesophageal reflux disease (GERD), structural processes, motor dysfunction, behavioral conditions, or functional disorders. physiologic tests often performed when initial endoscopic evaluation is unrevealing, especially persist despite empiric management. Commonly used esophageal include manometry, ambulatory monitoring, barium esophagram. Functional lumen imaging probe (FLIP) has recently been approved for pressure...
SUMMARY Background Mean nocturnal baseline impedance ( MNBI ), a novel pH ‐impedance metric, may be surrogate marker of reflux burden. Aim To assess the predictive value on symptomatic outcomes after anti‐reflux therapy. Methods In this prospective observational cohort study, studies performed over 5‐year period were reviewed. Baseline was extracted from six channels at three stable 10‐min time periods, and averaged to yield . Distal proximal oesophageal values calculated by averaging 3, 5,...
INTRODUCTION: Artificial intelligence chatbots could serve as an information resource for patients and a tool clinicians. Their ability to respond appropriately questions regarding gastroesophageal reflux disease is unknown. METHODS: Twenty-three prompts management were submitted ChatGPT, responses rated by 3 gastroenterologists 8 patients. RESULTS: ChatGPT provided largely appropriate (91.3%), although with some inappropriateness (8.7%) inconsistency. Most (78.3%) contained at least...
Abstract Background Ineffective esophageal motility ( IEM ) is associated with reflux disease, but its natural history unclear. We evaluated patients undergoing repeat high resolution manometry HRM for symptomatic presentations after antireflux surgery ARS to understand the progression of . Methods Patients were included. was diagnosed if ≥5 sequences had distal contractile integral DCI <450 mmHg cm s. Augmentation following multiple rapid swallows MRS assessed. The esophagogastric...
The esophagogastric junction contractile integral (EGJ-CI), designed similar to distal (DCI), has been proposed as a metric evaluate EGJ barrier function. We determined normative values and evaluated EGJ-CI in predicting esophageal acid exposure time (AET) symptomatic outcome this observational cohort study. High-resolution manometry (HRM) studies were reviewed 188 patients (55.2 ± 0.9 years, 64% female) undergoing ambulatory pH monitoring off therapy. Dominant symptoms global symptom...
Abstract Background Esophagogastric junction contractile integral ( EGJ ‐ CI ) assesses barrier function on esophageal high resolution manometry HRM ). We assessed values in achalasia and gastroesophageal reflux disease GERD to determine if postoperative changes reflected surgical intervention. Methods Twenty‐one patients (42.8 ± 3.2 years, 62% F) with before after Heller myotomy HM 68 (53.9 1.8 66% undergoing antireflux surgery ARS were compared 21 healthy controls (27.6 0.6 52% F)....
pH-impedance testing detects reflux events irrespective of pH, but its value in predicting treatment outcome is unclear. We prospectively evaluated subjects treated medically after to determine predictors symptom improvement.Subjects referred for completed questionnaires which dominant symptoms and global severity (GSS) were recorded. Acid-reflux parameters (acid-exposure time, AET; association by Ghillebert probability estimate, GPE; index, SI) impedance (reflux-exposure RET; number events;...
Abstract Background Positive symptom association probability ( SAP ) with physiologic esophageal acid exposure time AET on pH‐impedance monitoring defines reflux hypersensitivity RH ), a correlate of sensitivity pH monitoring. We evaluated prevalence, clinical characteristics, and symptomatic outcomes in prospective observational cohort symptoms undergoing Methods Reflux was diagnosed when positive pH‐ and/or impedance‐detected events . Symptom burden assessed using dominant intensity DSI ,...
INTRODUCTION: Chronic idiopathic constipation (CIC) is a common disorder associated with significant impairment in quality of life. This clinical practice guideline, jointly developed by the American Gastroenterological Association and College Gastroenterology, aims to inform clinicians patients providing evidence-based recommendations for pharmacological treatment CIC adults. METHODS: The Gastroenterology formed multidisciplinary guideline panel that conducted systematic reviews following...