A5014465006- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Gallbladder and Bile Duct Disorders
- Liver physiology and pathology
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Glycosylation and Glycoproteins Research
- Gastrointestinal Tumor Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Phagocytosis and Immune Regulation
- Esophageal and GI Pathology
- Ovarian cancer diagnosis and treatment
- Gastrointestinal disorders and treatments
- Galectins and Cancer Biology
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Lung Cancer Treatments and Mutations
- Surgical site infection prevention
- Gastroesophageal reflux and treatments
- Endoplasmic Reticulum Stress and Disease
- Protease and Inhibitor Mechanisms
- Immune cells in cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Diversity and Career in Medicine
Providence Portland Medical Center
2022-2025
Oregon Clinic
2022-2025
University of California, San Diego
2011-2019
Mucinous neoplasms of the appendix (MNA) are rare tumors which may progress from benign to malignant disease with an aggressive biological behavior. MNA is often diagnosed after metastasis peritoneal surfaces resulting in mucinous carcinomatosis peritonei (MCP). Genetic alterations poorly characterized due its low incidence, hypo-cellularity MCPs, and a lack relevant pre-clinical models. As such, application targeted therapies this limited those developed for colorectal cancer not based on...
The recepteur d'origine nantais (RON) receptor tyrosine kinase is overexpressed and stimulates invasive growth in pancreatic cancer cells, yet the mechanisms that underlie RON-mediated phenotypes remain poorly characterized. To better understand RON function we sought to identify novel interactants using multidimensional protein identification analysis. These studies revealed plectin, a large of spectrin superfamily, be interactant. Plectin multifunctional complexes with integrin-β4 (ITGB4)...
Gastrointestinal stromal tumor (GIST) is the most common sarcoma and its treatment with imatinib has served as paradigm for developing targeted anti-cancer therapies. Despite this success, imatinib-resistance emerged a major problem therefore, clinical efficacy of other drugs been investigated. Unfortunately, trials have failed to identify efficacious despite promising in vitro data pathological responses subcutaneous xenografts. We hypothesized that it was feasible develop orthotopic...
The RON tyrosine kinase receptor is under investigation as a novel target in pancreatic cancer. While mutations are uncommon, isoforms produced cancer cells via variety of mechanisms. In this study we sought to: 1) characterize isoform expression cancer, 2) investigate mechanisms that regulate expression, and 3) determine how various effect gene oncogenic phenotypes responses to directed therapies. We quantified transcripts human found levels 2500 fold normal pancreas with comprising nearly...
In pancreatic neuroendocrine tumors (PNETs), the impact of minimally invasive (MI) versus open resection on outcomes remains poorly studied. We queried a multi-institutional cancer registry for patients with resected non-metastatic PNET from 1996−2020. Recurrence-free (RFS), disease-specific survival (DSS), and operative complications were evaluated. Two hundred eighty-two identified. Operations in 139 (49%) MI 143 (51%). Pancreaticoduodenectomy was performed 77 (27%, n = 23 MI), distal...
Abstract Mucinous Neoplasm of the Appendix (MNA) is a rare malignancy often diagnosed after metastasis to peritoneal surfaces resulting in Carcinomatosis Peritonei (MCP). Genetic alterations MNA are poorly characterized due its low incidence, hypo-cellularity MCPs and lack relevant pre-clinical models. As such, application targeted therapies this disease limited those developed for colorectal cancer (CRC) not based on molecular rationale. We sequenced whole exomes 10 identify genome-wide...
Abstract Introduction: The RON (receptor d'origine nantais) tyrosine kinase is overexpressed in >80% of human pancreatic cancers, but its effect on carcinogenesis largely unknown. Methods: We developed a transgenic mouse that overexpresses specifically the pancreas (Pdx-1-RON). Additionally, we utilized an existing with functionally inactive domain (Pdx-1-RTK-/-). These strains were crossed established CK murine model cancer yielding compound strains, RCK and CK/TK-/-. performed...
Abstract Introduction:The RON tyrosine kinase receptor is increasingly overexpressed during progression to Pancreatic Intraepithelial Neoplasia (PanIN) and pancreatic duct adenocarcinoma (PDAC). expression in these neoplastic cells associated with a highly invasive phenotype resistance gemcitabine. Mutations the gene for RON, MST1R, are rare but alternative splicing produces wide variety of protein isoforms. Exon skipping most common exon 11 RONΔ165. Alternative transcription start intron 10...