A5057715381- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Nonlinear Dynamics and Pattern Formation
- Cardiovascular Health and Disease Prevention
- Mathematical Biology Tumor Growth
- Theoretical and Computational Physics
- Chaos control and synchronization
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Statistical Mechanics and Entropy
- Advanced MRI Techniques and Applications
- Fluid Dynamics and Turbulent Flows
- Advanced Thermodynamics and Statistical Mechanics
- Combustion and flame dynamics
- Quantum chaos and dynamical systems
- Cardiac Arrhythmias and Treatments
- Laser-Matter Interactions and Applications
- Heart Rate Variability and Autonomic Control
- Gene Regulatory Network Analysis
- Pulmonary Hypertension Research and Treatments
- Advanced Radiotherapy Techniques
- Cancer Cells and Metastasis
- Particle Dynamics in Fluid Flows
- Neural Networks and Applications
- Congenital Heart Disease Studies
National University of Distance Education
2008-2019
Universidad a Distancia de Madrid
2016
University of Havana
2003-2014
Hospital General Universitario Gregorio Marañón
1999-2011
Distance State University
2002-2009
Universidad Rey Juan Carlos
2007
Universidad Carlos III de Madrid
2004-2005
University of Ottawa
2004
University of Washington
2004
Universidad Complutense de Madrid
2002
Aims The aim of this study was to determine the utility pulsed wave Doppler tissue imaging in evaluation regional left ventricular diastolic function patients with ischaemic heart disease. Methods and Results In 30 normal subjects 43 disease, performed each 16 segments myocardium. following parameters were obtained for segment: (1) early peak velocity (regional e cm.s−1); (2) late a (3) e/a ratio; (4) isovolumic relaxation time, defined as time interval from second sound onset E wave. these...
Doppler echocardiography remains the most extended clinical modality for evaluation of left ventricular (LV) function. Current ultrasound methods, however, are limited to representation a single flow velocity component. We thus developed novel technique construct 2D time-resolved (2D+t) LV fields from conventional transthoracic acquisitions. Combining color-Doppler velocities with wall positions, cross-beam blood were calculated using continuity equation under planar assumption. To validate...
Diastolic suction is a major determinant of early left ventricular filling in animal experiments. However, remains incompletely characterized the clinical setting.First, we validated method for measuring spatio-temporal distributions diastolic intraventricular pressure gradients and differences (DIVPDs) by digital processing color Doppler M-mode recordings. In 4 pigs, error peak DIVPD was 0.0+/-0.2 mm Hg (intraclass correlation coefficient, 0.95) compared with micromanometry. Forty patients...
Ejection intraventricular pressure gradients are caused by the systolic force developed left ventricle (LV). By postprocessing color Doppler M-mode (CDMM) images, we can measure noninvasively ejection difference (EIVPD) between LV apex and outflow tract. This study was designed to assess value of Doppler-derived EIVPDs as noninvasive indices chamber function.CDMM images pressure-volume (conductance) signals were simultaneously acquired in 9 minipigs undergoing pharmacological interventions...
During late ejection, myocardial relaxation causes systolic flow to decelerate and stop, this phenomenon is coupled with the generation of a pressure gradient inside left ventricle (LV). We hypothesized that peak reverse ejection intraventricular difference (REIVPD) between LV apex outflow tract could be useful method improve assessment using Doppler echocardiography.Three sets animal experiments 1 clinical study were designed. In 6 pigs, close relationship REIVPD intensity wave (R(rm)=0.89)...
Cardioembolic stroke is a major source of mortality and disability worldwide. The authors hypothesized that quantitative characterization intracardiac blood stasis may be useful to determine cardioembolic risk in order personalize anticoagulation therapy. aim this study was assess the relationship between image-based metrics left ventricle brain microembolism, surrogate marker cardiac embolism, controlled animal experimental model acute myocardial infarction (AMI).Intraventricular maps were...
Sufficiently long population decay times and sufficiently short dipole in a single-mode laser with saturable absorber permit passive $Q$ switching the form of hard-mode sustained relaxation oscillation.
An on-lattice Monte Carlo model is implemented for the simulation of particle deposit growth by advection and diffusion towards a flat surface. The structure characterized its bulk (density) interface (mean height surface width) properties. Numerical correlations, fitted simple expressions, are reported these magnitudes, relating them to time (number deposited particles) Peclet number. Also heuristic argument presented which relates density local diffusion-limited-aggregation-like processes...
Experiments in rupture of mercury drops have been performed recording the size distribution cumulative number for different conditions rupture. A transition from log-normal to scaling behavior is shown. To describe it, a geometric probabilistic model proposed. Consequently, can be described as process percolation Bethe lattice. Then, and viewed problem phase transition. Comparison with several fracture experimental data also made showing possibilities this viewpoint.
The expression of survival factors for radiation damaged cells is currently based on probabilistic assumptions and experimentally fitted each tumor, radiation, conditions. Here, we show how the simplest these radiobiological models can be derived from maximum entropy principle classical Boltzmann-Gibbs expression. We extend this derivation using Tsallis a cutoff hypothesis, motivated by clinical observations. obtained shows remarkable agreement with experimental data found in literature.
Background: Intracardiac flow homeostasis requires avoiding blood stasis and platelet activation during its transit through the cardiac chambers. However, foundations of intraventricular washout exposure to shear stresses have been poorly addressed. We aimed characterize quantify these features in a wide population healthy subjects assess relationships indices with age. Methods: used color-Doppler echocardiography custom post-processing methods study 149 volunteers from 26 days 80 years old....
Sufficiently long population decay times and sufficiently short dipole in a single-mode model for laser with saturable absorber permit coexistence of soft-excited oscillations $Q$ switching (hard-mode sustained relaxation oscillations).
The physiological basis of right ventricular (RV) diastolic function remains incompletely studied in humans. driving force responsible for RV filling, the pressure gradient along inlet from atrium to apex, has never been measured clinical setting.We validated a method measuring filling difference (RVFPD) color Doppler M-mode recordings 12 pigs undergoing interventions on preload, afterload, and lusitropic states (error, -0.1+/-0.4 mm Hg compared with micromanometers; intraclass correlation...
A cytokine-based periodic immunotherapy treatment is included in a model of tumour growth with delay. The effects dose schedule are studied the case weak immune system and growing tumour. We find existence 'metastable' states (that may last for tens years) induced by also potentially adverse dosage frequency on stabilization These two depend delay between response, cytokine burden, other parameters considered model.
In cardiovascular research, relaxation and stiffness are calculated from pressure-volume (PV) curves by separately fitting the data during isovolumic end-diastolic phases (end-diastolic PV relationship), respectively. This method is limited because it assumes uncoupled active passive properties these phases, penalizes statistical power, cannot account for elastic restoring forces. We aimed to improve this analysis implementing a based on global optimization of all diastolic data. 1,000 Monte...
AimsThe physiological determinants of RV diastolic function remain poorly understood. We aimed to quantify the contribution elastic recoil filling and determine its sensitivity interventricular interaction.
Lévy flights representation is proposed to describe earthquake characteristics like the distribution of waiting times and position hypocenters in a seismic region. Over 7500 microearthquakes earthquakes from 1985 1994 were analyzed test that its spatial temporal distributions are such can be described by flight with anomalous diffusion (in this case subdiffusive regime). Earthquake behavior well through functions as results show.
The structure of granular deposits growing by arriving particles is analyzed using three-dimensional on-lattice Monte Carlo modeling convective-diffusive particle deposition. deposit density profile rho(h) depends on the dynamics and becomes formed three different regions: a denser near-wall region at bottom in contact with original plain surface, middle uniform constant mean density, an open lighter active-growth outer surface. Fitting expressions for valid each are proposed, based known...