Jacopo Del Meglio

ORCID: 0000-0003-2937-1000
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About
Contact & Profiles
Research Areas
  • Cardiac Imaging and Diagnostics
  • Advanced MRI Techniques and Applications
  • Advanced X-ray and CT Imaging
  • Cardiovascular Function and Risk Factors
  • Cardiomyopathy and Myosin Studies
  • Chemotherapy-induced cardiotoxicity and mitigation
  • Radiomics and Machine Learning in Medical Imaging
  • Coronary Interventions and Diagnostics
  • Acute Myocardial Infarction Research
  • Cardiac pacing and defibrillation studies
  • Cancer Treatment and Pharmacology
  • Radiation Dose and Imaging
  • Congenital Heart Disease Studies
  • Cardiac Valve Diseases and Treatments
  • Cardiac Structural Anomalies and Repair
  • Cardiac electrophysiology and arrhythmias
  • Heart Failure Treatment and Management
  • Coronary Artery Anomalies
  • Pericarditis and Cardiac Tamponade
  • Cardiac tumors and thrombi
  • Soft tissue tumor case studies
  • Polymer Nanocomposite Synthesis and Irradiation
  • Medication Adherence and Compliance
  • Cardiac, Anesthesia and Surgical Outcomes
  • Lipoproteins and Cardiovascular Health

Ospedale Versilia
2015-2024

Inserm
2022

Institut de Recherche pour le Développement
2022

Université de Limoges
2022

Nuovo Ospedale di Prato
2022

Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2022

Mario Negri Institute for Pharmacological Research
2020

Istituti di Ricovero e Cura a Carattere Scientifico
2020

Florence (Netherlands)
2005

Azienda Ospedaliero-Universitaria Careggi
2005

Cardiovascular toxicity of immunotherapy represents an underreported but potentially fatal side effect. A relatively high incidence pericardial disease has been noticed in patients with non-small cell lung cancer (NSCLC). We retrospectively analyzed a population advanced NSCLC receiving immune checkpoint inhibitors (ICIs) looking for the presence effusion at baseline or during treatment. The study was compared control group treated chemotherapy. All were checked concomitant pleural effusion....

10.1007/s12325-020-01386-y article EN cc-by-nc Advances in Therapy 2020-05-20

Radiomics and artificial intelligence have the potential to become a valuable tool in clinical applications. Frequently, radiomic analyses through machine learning methods present issues caused by high dimensionality multicollinearity, redundant features are usually removed based on correlation analysis. We assessed effect of preprocessing—in terms voxel size resampling, discretization, filtering—on correlation-based reduction from cardiac T1 T2 maps patients with hypertrophic...

10.3390/bioengineering10010080 article EN cc-by Bioengineering 2023-01-06

Abstract Radiomics is emerging as a promising and useful tool in cardiac magnetic resonance (CMR) imaging applications. Accordingly, the purpose of this study was to investigate, for first time, effect image resampling/discretization filtering on radiomic features estimation from quantitative CMR T1 T2 mapping. Specifically, maps 26 patients with hypertrophic cardiomyopathy (HCM) were used estimate 98 7 different resampling voxel sizes (at fixed bin width), 9 widths size), spatial filters...

10.1038/s41598-022-13937-0 article EN cc-by Scientific Reports 2022-06-17

Three-dimensional (3D)-echocardiography speckle imaging allows the evaluation of frame-by-frame strain and volume changes simultaneously. The aim present investigation was to describe strain–volume combined assessment in different patterns cardiac remodelling. Fifty patients received a 3D acquisition. Patients were classified as follows: healthy subjects (CNT), previous AMI, normal ejection fraction (EF; group A); ischaemic cardiomyopathy with reduced EF (group B); hypertrophic/infiltrative...

10.1093/ejechocard/jer073 article EN European Journal of Echocardiography 2011-06-14

Effective anticancer treatments have dramatically improved the outcome of patients with cancer, but cardiac toxicity reduces their clinical efficacy in a non-negligible percentage patients. Sacubitril/valsartan is new paradigm treatment chronic heart failure, reduced ejection fraction due to enhancement natriuretic peptides' properties when coupled blocking effect on angiotensin II type 1 (AT1) receptors. As other conditions failure potentially reversible declines function, wearable...

10.3389/fcvm.2022.801143 article EN cc-by Frontiers in Cardiovascular Medicine 2022-03-01

Cardiovascular risk factors (CVRFs) predict cardiotoxicity in cancer patients but their role late cardiac toxicity is less clear.This was a retrospective analysis of treated with anthracyclines (A) and/or trastuzumab (T) and correlation early (≤5 years) or (>5 toxicity, baseline CVRFs at time.A total 610 were included, 422 (Group A) 188 without B) CVRFs. In group A incidence 4.7% all events during treatment immediately after [mean onset time 0.7 years (range=0.2-1.6)]. Events rate 3.2% B...

10.21873/anticanres.13775 article EN Anticancer Research 2019-09-30

The aim of this study is to compare three-dimensional echocardiography strain-volume analysis with tagging cardiac magnetic resonance (cMR) measurements.Strain-volume represents a noninvasive method assess myocardial function and volumes simultaneously. It can be derived from speckle-tracking; however, it shows some variability that limit clinical utilization. A approach partially overcomes these limitations since full-volume acquisition avoids images being foreshortened geometrical...

10.2459/jcm.0000000000000336 article EN Journal of Cardiovascular Medicine 2015-12-24

Background: Left ventricular ( LV ) twist represents a main aspect of ejection. It is defined as the difference between apical and basal rotation can be assessed by speckle tracking echocardiography STE ). Twist may underestimated when two‐dimensional‐echocardiography due to difficulty identifying real apex. Aim this study was evaluate means three‐dimensional (3 D )‐ verify if inclusion apex modify assessment global twist. Methods: volume acquisition with fully sampled matrix array...

10.1111/echo.12026 article EN Echocardiography 2012-11-21

Abstract Introduction In our Center, patients (pts) with newly diagnosed HF and reduced LVEF underwent MRI to determine the presence extension of delayed enhancement (DE) or scar areas. These were discharged a wearable cardioverter defibrillator (WCD) as monitoring temporary antiarrhythmic therapy until three-month follow-up (FU). Subsequent FU was performed at 6 12 months. Methods From May 2016 July 2023, 120 consecutive pts (97 M; mean age 65.3y±9.7y) EF (28.5%±8.5%) on OMT, WCD included...

10.1093/europace/euae102.369 article EN cc-by-nc EP Europace 2024-05-01

Multidetector coronary computed tomography angiography (CCTA) is increasingly used for noninvasive imaging of the arteries. Radiation exposure, however, a potential limitation to more extensive use this modality. We aimed demonstrate that professional teamwork approach, including cardiologist and radiologist in performing CCTA, may allow obtain best quality exams with very low radiation doses.A total 998 consecutive patients underwent CCTA accordance most recent guidelines. The following...

10.1714/2683.27474 article EN PubMed 2017-04-01

With the widespread use of multidetector computed tomography (MDCT) coronary angiography, cardiac and extracardiac incidental findings in imaging might be detected. The aim this study was to determine prevalence a population consecutive patients undergoing MDCT.A total 840 with known or suspected heart disease underwent MDCT. All were assessed 64-slice MDCT; examination performed by limiting anatomical region examined between bifurcation trachea apex obtaining excellent image quality low...

10.1714/2252.24264 article EN PubMed 2016-05-01

<p><span style="font-size: medium;"><span style="font-family: Times New Roman;"><strong>Background:</strong> Transthoracic echocardiography (TTE) may detect the origin and/or abnormal course of coronary epicardial vessels. We describe a novel TTE pattern specific for anomalous left vessel from right sinus and posterior its prevalence in an unselected population ambulatory patients.</span></span></p><p> </p><p><span...

10.17987/icfj.v8i0.309 article EN International Cardiovascular Forum Journal 2016-10-31

The burden of cardiac side effects in oncology patients will dramatically increase the near future as a result widespread use anticancer agents affecting cardiovascular system, general population aging, heightened attention detection toxicity and absolute gain terms overall survival. relationship between cardiologists oncologists should therefore be closer leading to definition cardio-oncology. increased number such requires creation dedicated patient assistance program order guarantee every...

10.1714/2803.28361 article EN PubMed 2017-11-01
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