A5020702273- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Nerve injury and regeneration
- Neurotransmitter Receptor Influence on Behavior
- Olfactory and Sensory Function Studies
- Nicotinic Acetylcholine Receptors Study
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Nuclear Receptors and Signaling
- Dental Anxiety and Anesthesia Techniques
- Tryptophan and brain disorders
- Zebrafish Biomedical Research Applications
- Pharmacological Effects and Toxicity Studies
- Animal Behavior and Reproduction
- Sleep and Wakefulness Research
- Natural Compound Pharmacology Studies
- Medicinal Plant Extracts Effects
- Essential Oils and Antimicrobial Activity
- Alkaloids: synthesis and pharmacology
- Computational Drug Discovery Methods
- Occupational health in dentistry
- Curcumin's Biomedical Applications
Universidade Estadual de Ponta Grossa
2013-2024
Universidade Federal do Paraná
2003-2009
Lavandula angustifolia (lavender) inhalation has been used in folk medicine for the treatment of anxiety, and clinical animal studies have corroborated its anxiolytic effect, although mechanism action is still not fully understood. The objective present study was to determine whether GABAA/benzodiazepine complex or serotonin neurotransmission mediates anxiolytic-like effect lavender essential oil. Male Swiss mice were subjected marble-burying test after being exposed aroma oil (1–5%), amyl...
The inhalation of Lavandula angustifolia (lavender) essential oil has anxiolytic-like effects in animal models and humans, but its mechanism action is still not fully understood. oils can induce anxiolytic through the central nervous system (e.g., lung absorption bloodstream transport) or stimulation olfactory secondary activation brain regions. Thus, main objective present study was to evaluate whether perception lavender aroma, when inhaled, necessary obtain mice tested marble-burying...
Parkinson’s disease (PD) is a multifactorial disease, with genetic and environmental factors contributing to the onset. Classically, PD movement disorder characterized by loss of dopaminergic neurons in nigrostriatal pathway intraneuronal aggregates mainly constituted protein α-synuclein. However, patients also display non-motor symptoms, including depression, which have been linked functional abnormalities non-dopaminergic neurons, serotonergic noradrenergic ones. Thus, through this...
There is a great concern in the literature for development of neuroprotectant drugs to treat Parkinson's disease. Since anesthetic have hyperpolarizing properties, they can possibly act as neuroprotectants. In present study, we investigated neuroprotective effect mixture ketamine (85 mg/kg) and xylazine (3 (K/X) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 6-hydroxydopamine (6-OHDA) rat models The bilateral infusion MPTP (100 µg/side) 6-OHDA (10 into substantia nigra pars...
Background . Orthostatic hypotension (OH) is an important nonmotor manifestation of Parkinson’s disease (PD). Changes in cerebrovascular reactivity may contribute to this and can be monitored using transcranial Doppler. Objective To identify possible changes patients with OH. Methods Twenty-two individuals were selected divided into three groups: without OH controls. Transcranial Doppler was used assess basal mean blood flow velocity, postapnea percentage increase as measured by the...
The substantia nigra pars compacta (SNc) and the dorsal striatum are often considered to be necessary for stimulus-response (S-R) habit learning, whereas hippocampus is relational (declarative) memory. Spatial learning a kind of that occurs when rat released from different locations (variable start) in water maze find submerged platform kept constant location. However, always same starting position (constant start), it can learn oriented by fixed configuration cues, is, S-R learning. To test...
Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by the slow and progressive death of dopaminergic neurons in (substantia nigra pars compact). Hypericum perforatum (H. perforatum) a plant widely used as antidepressant, that also presents antioxidant anti-inflammatory properties. We evaluated effects H. on turning behavior rats submitted to unilateral administration 6-hydroxydopamine (6-OHDA) into medial forebrain bundle animal model PD. The animals were...
HIGHLIGHTS: Tumor progression and anxiety depression behaviors under evaluation during propranolol use in murine melanoma. Evaluation of through forced swimming behavior tests, elevated plus maze, open field marble-burying test.
The anxiety disorders belong to a group of mental in which the patients present excessive fear and worry. Studies with ferulic acid have shown positive results on treating depressive symptoms. As many antidepressive drugs are effective anxiety, objective study was evaluate acid’s anxiolytic activity possible mechanism action light-dark test zebrafish. To activity, preference performed after exposure animals or control (clonazepam fluoxetine). Ferulic increased time spent clear compartment at...
Background: Pain is a frequent non-motor symptom in patients with Parkinson’s disease (PD) and appears to be related low levels of dopamine. This study describes the characteristics chronic pain group PD undergoing levodopa therapy. Methods: was cross-sectional study. The assessed 21 selected using several scales instruments. Changes response from use (wearing-off phenomenon) were monitored. Results: most prevalent type nociceptive (71.4%), musculoskeletal dystonic, but neuropathic accounted...
The dopaminergic system is involved in a wide range of neuropsychiatric and neurodegenerative disorders. lack receptor subtype specificity related to several pharmacological side effects that are observed during therapy among parkinsonian schizophrenic patients. It paramount importance search for new compounds act on dopamine receptors with therapeutic potential, higher clinical effectiveness, fewer adverse effects. In the present study, we performed molecular docking study D2, D3, D4...
Objective: The aim was to identify changes in cerebrovascular autoregulation patients with orthostatic hypotension (OH) associated Parkinson9s disease (PD). Background: PD is characterized by degeneration of specific neurons slow caudal-rostral progression. This the main explanation for non-motor manifestations disease. Usually, decrease systemic blood pressure offset an increase sympathetic tone and dilation cerebral vessels. Changes mechanisms maintain flow possibly occur onset OH....