A5056993627- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- COVID-19 and healthcare impacts
- Uterine Myomas and Treatments
- Economic and Financial Impacts of Cancer
- Intraperitoneal and Appendiceal Malignancies
- Clinical practice guidelines implementation
- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- BRCA gene mutations in cancer
- Health Policy Implementation Science
- Metabolism, Diabetes, and Cancer
- Ethics in Clinical Research
- Advanced Biosensing Techniques and Applications
- PARP inhibition in cancer therapy
- Molecular Biology Techniques and Applications
- Immune cells in cancer
- Genetic factors in colorectal cancer
- Gene expression and cancer classification
- Colorectal and Anal Carcinomas
- Diversity and Career in Medicine
- Genomics and Rare Diseases
- Viral-associated cancers and disorders
- Cancer, Hypoxia, and Metabolism
Kaiser Permanente
2019-2025
Kaiser Permanente Riverside Medical Center
2019-2025
AID Atlanta
2021
Center for Surveillance, Epidemiology, and Laboratory Services
2021
White Memorial Medical Center
2019
Cedars-Sinai Medical Center
2016-2018
University of California, Los Angeles
2016-2018
Los Angeles Medical Center
2016
University of California, Irvine Medical Center
2013-2015
University of California, Irvine
2013-2014
On March 19, 2020, the governor of California issued a statewide stay-at-home order to contain spread SARS-CoV-2, virus that causes coronavirus disease 2019 (COVID-19).* The reduced accessibility and patient attendance at outpatient medical visits,† including preventive services such as cervical cancer screening. In-person clinic visits increased when reopened essential businesses on June 12, 2020.§ Electronic records approximately 1.5 million women served by Kaiser Permanente Southern...
Purpose: Evidence on the impact of coronavirus disease 2019 (COVID-19) pandemic outcomes in patients with ovarian cancer is limited. We compared remission before and during pandemic. Patients Methods: This retrospective cohort study included diagnosed epithelial between 01/01/2017 06/30/2021 at Kaiser Permanente Southern California. Pre post periods were designated using March 4, 2020, as cut-off. Stage I–IV who completed chemotherapy and/or surgery first-line treatment included. Data...
Uterine leiomyosarcoma (uLMS) is an aggressive mesenchymal tumor associated with a poor prognosis. Research demonstrates that PARP inhibitors (PARPi) improve disease-stable survival in patients somatic BRCA1/2 mutations through the process of synthetic lethality. Therefore, PARPi's may have role treating gynecologic malignancies deleterious mutations. This patient 50-year-old female history stage IB uterine leiomyosarcoma, complicated by recurrence along vaginal cuff and metastases to lungs....
Introduction The Coronavirus Disease 2019 (COVID-19) pandemic posed critical challenges in providing care to ovarian cancer (OC) patients, including delays OC diagnosis and treatment initiation. To accommodate for surgery, the Society of Gynecologic Oncology (SGO) recommended preferential use neoadjuvant chemotherapy during pandemic. purpose this study was assess association COVID-19 with patients diagnosed OC. Methods This retrospective cohort included stage II-IV epithelial subtype between...
Locked nucleic acids (LNA) are being applied in hybridization studies, but current locked nucleotides cannot be transcribed into RNA probes. Here, the authors report use of a new synthetic nucleotide, locMeCytidine-5'-triphosphate (LNA-mCTP), for study. This LNA-mCTP can short (∼30-nt) probe. Dot blot on nylon membrane suggested that 33P-LNA probes had strong binding affinity to target oligonucleotides and its detection sensitivity was approximately ∼1000 miRNAs 20- 30-μm (diameter) dot...
// Melissa Hodeib 1, * , Martin P. Ogrodzinski 2, 3, Laurent Vergnes 4 Karen Reue Beth Y. Karlan 1 Sophia Lunt 2 and Paul-Joseph Aspuria Women's Cancer Program, Samuel Oschin Comprehensive Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA Department of Biochemistry Molecular Biology, Michigan State University, East Lansing, MI 48824, 3 Physiology, Human Genetics, David Geffen School Medicine, University California 90095, Co-first author Correspondence to: Aspuria, email:...
Tissue microarrays (TMAs) are widely used to analyze gene expression in multiple pathological samples on a single slide. Currently, most TMA slides made by coring paraffinembedded tissues and arraying them into paraffin block, from which sections cut. However, paraffin-based technology may not be compatible with frozen clinical tissue samples, have higher quality of RNAs proteins for preparing TMAs than paraffin-embedded samples. In this study, we developed an alternative that is applicable...
Sebaceous carcinomas are rare tumors, with the majority of described cases occurring within eyelid. To date, there nine documented reports sebaceous carcinoma arising a mature cystic teratoma ovary. Although originate from idiopathic mutations, exists strong association between this tumor and hereditary syndromes DNA mismatch repair deficiency, such as Lynch syndrome lesser-known Muir-Torre syndrome. Here we present case 67 year-old woman longstanding history small left ovarian cyst...
Abstract Background New cervical cancer screening guidelines recommend primary human papillomavirus (HPV) testing for women age 30–65 years. Healthcare organizations are preparing to de-implement the previous recommended strategies of Pap or co-testing (Pap plus HPV test) and substitute testing. However, there may be significant challenges replacement this entrenched clinical practice, even with an evidence-based substitution. We sought identify stakeholder-perceived barriers facilitators...
Solid pseudopapillary tumors are rare, with the majority of described cases originating in pancreas. To date, there only 10 documented reports primary ovarian solid tumors. Here, we describe case a 24-year-old woman who presented worsening pelvic pain and dysmenorrhea. Workup demonstrated right mass on ultrasound an elevated serum LDH, which raised concerns for dysgerminoma due to her relatively young age. Therefore, she was taken operating room underwent laparoscopic salpingo-oophorectomy....
Adult granulosa cell tumor (AGCT) is a sex cord stromal (SCST) which constitutes 2-5% of all ovarian cancers. Initial treatment early stage disease includes primary surgical resection with or without adjuvant treatment. Late and recurrent management involves multimodality as the mainstay. Given rarity this its relative chemoresistance, future study needed to better guide individualize therapy for patients. Further evaluation diagnostic potential therapeutic implications involving FOXL2...
e17562 Background: Several prior studies have examined the role of comorbidity on overall survival in ovarian cancer (OC) patients and reported an association between inferior survival. However, it is unclear if was solely due to excess mortality from comorbidities, or that comorbidities can impact OC treatment outcomes. Our objective determine whether pre-existing Charlson index (CCI) associated with lower likelihood achieving complete remission. Methods: This retrospective cohort study...