A5015600498- Extracellular vesicles in disease
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Atherosclerosis and Cardiovascular Diseases
- Fatty Acid Research and Health
- 3D Printing in Biomedical Research
- Immune Response and Inflammation
- Angiogenesis and VEGF in Cancer
- Advancements in Transdermal Drug Delivery
- Natural Products and Biological Research
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Adipose Tissue and Metabolism
- Neonatal Respiratory Health Research
- Heat shock proteins research
- Toxoplasma gondii Research Studies
- Cholesterol and Lipid Metabolism
- Sepsis Diagnosis and Treatment
- Ion Channels and Receptors
- Cardiac Fibrosis and Remodeling
- Congenital heart defects research
- Neuroscience and Neuropharmacology Research
- Biomarkers in Disease Mechanisms
Koç University
2020-2025
Tabriz University of Medical Sciences
2018-2021
University of Mazandaran
2019
Cardiovascular diseases are the main cause of death globally. Many attempts have been done to ameliorate pathological changes after occurrence myocardial infarction. Curcumin is touted as a polyphenol phytocompound with appropriate cardioprotective properties. In this study, therapeutic effect curcumin was investigated on acute infarction in model rats. Rats were classified into four groups; control, isoproterenol hydrochloride (ISO) (100 mg/kbw), (50 and plus ISO treatment groups. After...
The mechanisms underlying neurodegeneration in multiple sclerosis remain incompletely understood. In this study, we aimed to investigate the role of vascular dysfunction cortical using a chronic cranial window model experimental autoimmune encephalomyelitis mice. After induction with myelin oligodendrocyte glycoprotein peptides C57BL/6J mice, assessed cerebrovascular reactivity though laser speckle contrast imaging and intrinsic optical signal awake animals. We observed significant reduction...
Biocompatible, biodegradable, and injectable hydrogels are a novel promising approach for bone regeneration. In this study, poly(caprolactone)–poly(ethylene glycol)–poly(caprolactone) (PCL-PEG-PCL), PCL-PEG-PCL-gelatin (Gel), PCL-PEG-PCL-Gel/nano-hydroxyapatite (nHA) were synthesized evaluated in mouse model of subcutaneous transplantation after 14 days. PCL-PEG-PCL-Gel PCL-PEG-PCL-Gel/nHA fabricated with situ precipitation method. Structure, intermolecular interaction, the reaction between...
Abstract Heat shock proteins (HSPs) participate in the regulation of different cell activities response to stimuli. By applying strategies, modulation heat is at center attention. Conventional delivery approaches are not fully encouraged due cytotoxicity and immunogenicity issues. Exosomes touted as bio‐shuttles for distinct biomolecules inside cells. Here, we aimed HSP27 small interfering RNA (siRNA)‐tagged exosomes inhibition Hsp27 human neuroblastoma line SH‐SY5Y explored differentiation...
Purpose: Here, we investigated the angiogenic potential of endothelial progenitor cells juxtaposed with mesenchymal stem (MSCs) inside alginate-gelatin microspheres stromal derived factor-1α (SDF-1 α) for 7 days. Methods: Six encapsulated groups were allocated including (EPCs), EPCs/SDF-1α, MSCs, MSCs/SDF-1α, EPCs+MSCs and EPCs+MSCs/SDF-1α. Cells a mixture 1% alginate 2% gelatin hydrogel. Cell survival was examined by MTT assay. Endothelial differentiation determined flow cytometry ELISA....
Abstract Background Atherosclerosis is touted as one of the most critical consequences diabetes mellitus indicated by local inflammation endothelial cells. The Effect Omega 3 fatty acids, mainly docosahexaenoic acid (DHA), has been investigated in cells after exposure to high doses lipids. current experiment aimed address modulatory effects and insulin palmitic-treated human Methods Human umbilical vein were treated with 1 mM palmitic acid, 50 μM insulin, their combination for 48 h. Cell...
What is the central question of this study? The aim experiment was to highlight regenerative capacity bone marrow Kit+ cells in restoration asthmatic pulmonary function rat model. main finding and its importance? Data showed that these were recruited successfully niche after intratracheal administration accelerated regeneration lungs by modulation inflammation via control Gata3 Tbx21 expression, leading decreased tracheal responsiveness methacholine reduction pathological...
In this study, cardiovascular disorders were examined with a focus on the aging pathway and autophagy involvement in cardiac samples isolated from male rats type 2 diabetes mellitus. present Wistar became diabetic help of high-fat diet. Gene protein expression levels (to evaluate Tumor Necrosis Factor-α, TNF-α) measured by ELISA method. Nrf2, p38, GSK-3β proteins tissue western blotting Autophagy examination was performed immunofluorescence staining. Finally, quantitative results calculated...
The emergence of an inflammatory condition such as asthma could affect the therapeutic potential stem cells. Synopsis previous documents yielded controversial outcomes, leading to a limitation cell‐based therapy in clinical setting. This study aimed assess impact asthmatic serum on MSCs aging and dynamic growth vitro. Rats were divided into control groups randomly. change was induced using OVA sensitization. structural changes are monitored by conventional Haematoxylin‐Eosin staining....