In the current work, a new series of benzo[b][1, 4] diazepines (A-1 to C-4) was synthesized and screened against three different human cancer cell lines, HepG2 (hepatocellular carcinoma), HeLa (cervical cancer) MCF-7 (breast cancer), by employing MTT (MTT 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assay. The outcomes in vitro screening revealed that all compounds exhibited momentous anticancer activity, most notably line B1–4 compounds. Further, network pharmacology,...

Solvothermal synthesis of hierarchical orthorhombic Sb 2 WO 6 nanostructures on layered GO for heavy metal ion sensing and photocatalysis.

Despite its limited exploration, Nymphaea mexicana Zucc. can be beneficial if pharmacology, isolation, and biological evaluation are given attention. It is an aquatic species that belongs to the family Nymphaeaceae. The thrust area of work was extraction, different extracts N. plant. primary goal this research assess antimicrobial, antioxidant, anticancer activities isolate target naringenin compound. Comparative FT IR analysis plant revealed presence functional groups secondary metabolites,...

This work was carried out to evaluate chemical composition, antibacterial, antioxidant and anticancer activity of Pinus roxburghii essential oil. The oil extracted by hydro-distillation which analysed through GC-MS. antibacterial evaluated agar well diffusion method DPPH assay while as MTT method. Alpha-pinene beta-pinene were the major constituents present in showed significant activity.

Retinoic acid induces differentiation in various types of cells including skeletal myoblasts and neuroblasts maintains epithelial cells. The present study demonstrates synthesis screening a library retinoic acid-triazolyl derivatives for their potential on neuroblastoma Click chemistry approach using copper(I)-catalyzed azide–alkyne cycloaddition was adopted the preparation these derivatives. neurite outgrowth promoting studied Morphological examination revealed that compounds 8a, 8e, 8f,...

Abstract The analysis of Skimmia laureola hydrodistillate by gas chromatography coupled with mass spectrometry revealed the presence 20 constituents, representing 94.6% total oil. major constituents oil were linalyl acetate (33.0%), linalool (25.0%), limonene (8.1%), α-terpineol (5.9%) and geranyl (5.9%). monoterpene (93.4%) rich essential was evaluated for its antibacterial antifungal activities against seven microorganisms agar diffusion microdilution methods. showed appreciable...

This study meticulously explores the antimicrobial potential of Prangos pabularia Lindl.'s aerial parts through a comprehensive blend in vitro and silico analysis. Extracts with varying polarities underwent LC-MS/MS identification active components, followed by assessments efficacy against Escherichia coli, Bacillus cereus, Candida albicans, glabrata, paropsilosis. The methanolic extract exhibited significant activity MIC value 48 μg/mL all tested strains. Molecular docking revealed compound...

AbstractIn this study, the phytochemical profile, pharmacological and antibacterial activity of essential oil (EO) obtained from whole plant Nepeta nervosa were investigated. The analysis was carried out by gas chromatography-mass spectrometry (GC-MS) about thirty-two chemical constituents detected, accounting 94.13% total composition. From GC-MS chromatogram, compounds like 2-Octanol (62.60%): Eucalyptol (14.68%) Nepetalactone (3.28%) Neral (2.88%) found in abundance. Furthermore, in-silico...

Abstract A mild and efficient visible light–mediated one‐pot multicomponent tandem approach to construct 4‐oxo‐tetrahydroindoles in ethanol–water medium at room temperature has been described. The characteristics of reported methodology are the utilization light, an ideal source energy generate CC CN bonds from commercially available substrates namely dimedone, phenacyl bromides, amines. presented protocol is highly compatible for developing 4‐oxo‐tetrahydroindole derivatives with improved...

Abstract Head space-Solid phase micro extraction (HS-SPME) technique has been used to examine terpene composition of Skimmia laureola. The chemical SPME extract obtained from leaves S. laureola was compared with essential oil by hydrodistillation the same plant. Both qualitative and quantitative differences have found in estimated analyzing HS-SPME Gas chromatography (GC) chromatography-mass spectrometry (GC-MS) analysis revealed sixteen constituents, representing 99.2 % oil, while as plant...

The importance of the present study is to find out phytochemical profile essential oil (EO) Artemisia tournefortiana Reichb. and its biological evaluation. Nineteen volatile constituents were identified from EO representing 93.47% total composition. Oxygenated monoterpenes (54.46%) found be dominant over other class compounds. cis-spiroether (47.66%), Z-β-farnesene (22.83%), trans-nerolidol (3.89%) camphor (3.80%) major constituents. first time in this region. Antibacterial effects observed...

Mahpara Qadira, Antim Kumar Mauryab, Ajaz Ahmad Wazac, Vijai Kant Agnihotrib & Wajaht A. Shaha*a Department of Chemistry, University Kashmir, Hazratbal, Srinagar, Jammu and India; b Natural Product Chemistry Process Development Division, CSIR-Institute Himalayan Bioresource Technology, Palampur (Himachal Pradesh), c Centre Research for (CORD), Srinagar

AbstractIn this study, we carried out the isolation of gallic acid from Hippophae rhamnoides plant followed by synthetic modification using Dicyclohexyl carbodimide (DCC) as a coupling reagent. The involves amidation Gallic one-step protocol, converting to its corresponding amide derivatives. reactions involve simple one-pot procedure with formation chain scaffolds various beneficial amides in good outstanding yields. synthesized were characterized several spectroscopic techniques like FTIR,...