A5035363714- Parasites and Host Interactions
- Global Maternal and Child Health
- Child Nutrition and Water Access
- Parasite Biology and Host Interactions
- Malaria Research and Control
- Helminth infection and control
- Mosquito-borne diseases and control
Kenya Medical Research Institute
2015-2022
Soil-transmitted helminth (STH) and schistosome infections are among the most prevalent neglected tropical diseases (NTDs) in world. School-aged children particularly vulnerable to these chronic that can impair growth, nutritional status cognitive ability. Mass drug administration (MDA) delivered either once or twice annually is a safe effective approach recommended by World Health Organization (WHO) reduce worm burden. In 2012, Kenya began national school-based deworming programme (NSBDP)...
In Kenya, over five million school age children (SAC) are estimated to be at risk of parasitic worms causing soil-transmitted helminthiasis (STH) and schistosomiasis. As such, the Government Kenya launched a National School Based Deworming (NSBD) program in 2012 targeting at-risk SAC living endemic regions, with aim reducing infections prevalence level where they no longer constitute public health problem. The impact has been consistently monitored from 2017 through robust extensive...
In 2012, the Kenyan Ministries of Health and Education began a programme to deworm all school-age children living in areas at high risk soil-transmitted helminths (STH) schistosome infections. The impact this school-based mass drug administration (MDA) Kenya is monitored by Medical Research Institute (KEMRI) as part five-year (2012–2017) study. This article focuses on MDA STH infections presents overall achieved reductions from baseline mid-term, well yearly patterns subsequent re-infections...
Kato-Katz technique has been the mainstay test in Schistosoma mansoni diagnosis endemic areas. However, recent studies have documented its poor sensitivity evaluating infection especially areas with lower rates of transmission. It's primary diagnostic tool monitoring impact Kenya national school based deworming program on transmission, but there is need to consider a more sensitive as prevalence reduces. Therefore, this study explored relationship between results stool-based urine-based...
Background. School age children are at high risk of soil-transmitted helminth (STH) worldwide. In Kenya, STH infections in remain despite the periodic administration anthelmintic drugs. Our study assessed prevalence and intensity primary school-aged Kakamega County, western Kenya. Methodology. We carried out a cross-sectional on population 731 attending 7 schools March 2014. Children aged 4–16 years were examined for by quantitative Kato-Katz technique. Infection intensities expressed as...
Under trial conditions insecticide-treated nets have been shown to provide significant clinical and mortality protection under a range of malaria transmission intensity conditions. There are, however, few operational impact data, notably in very intense This study, reports on infection among Kenyan schoolchildren living areas their reported use bed nets.5188 children 54 schools were randomly sampled from seven counties surrounding Lake Victoria between May June 2014. A questionnaire was...
Water, sanitation, and hygiene (WaSH) technologies behaviors can prevent infection by soil-transmitted helminth species independently, but may also interact in complex ways. However, these interactions are poorly understood. The purpose of this study was to characterize how school home WaSH exposures were associated with Ascaris lumbricoides identify relevant between separate behaviors. A conducted among 4,404 children attending 51 primary schools western Kenya. We used multivariable mixed...
Previously, we have shown that persons with human immunodeficiency virus 1 (HIV-1) infection and reduced CD4 + T-lymphocyte counts excrete significantly fewer Schistosoma mansoni eggs than HIV-1–negative similar intensities of schistosome infections. To determine how antiretroviral therapy (ART) might affect egg excretion, conducted a study HIV+ adults living in an area highly endemic for S. as they began ART program. Fecal excretion were evaluated at enrollment well 2 4 weeks after...
The current standard diagnostic tests for Schistosoma mansoni are the Kato-Katz and circulating cathodic antigen (CCA) techniques. However, these techniques have been documented to several limitations that a direct impact on schistosomiasis control programmes. Therefore, there is need more sensitive specific diagnosing schistosomiasis. This study compared performance of quantitative polymerase chain reaction (qPCR), Kato-Katz, point-of-care (POC-CCA) in diagnosis S. infection Mwea irrigation...
Intestinal geo-helminths are among the common human infections in developing world. Preschool and school-age children Kenya have been targeted for deworming strategies through National School-Based Deworming Program leaving out vulnerable groups including pregnant women. We conducted this study to assess prevalence intensity of worm associated risk factors women Western Kenya. A cross-sectional was carried 250 seeking antenatal care services from selected health facilities Vihiga County....