A5081913423- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Hormonal and reproductive studies
- Pharmacological Effects and Assays
- Pesticide Residue Analysis and Safety
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Forensic Toxicology and Drug Analysis
- Metabolomics and Mass Spectrometry Studies
- Antibiotics Pharmacokinetics and Efficacy
- Analytical chemistry methods development
- Eicosanoids and Hypertension Pharmacology
- Consumer Perception and Purchasing Behavior
- Alcohol Consumption and Health Effects
- Microbial bioremediation and biosurfactants
- Drug-Induced Hepatotoxicity and Protection
- Menstrual Health and Disorders
- Mast cells and histamine
- Liver Disease Diagnosis and Treatment
- Nanomaterials and Printing Technologies
- Analytical Methods in Pharmaceuticals
- Biosimilars and Bioanalytical Methods
- Tactile and Sensory Interactions
- Chemical Reactions and Isotopes
- Erythropoietin and Anemia Treatment
Inje University
2013-2018
Hanyang University
2018
Korea Institute of Science and Technology
2011-2018
Kyung Hee University
2018
Inje University Busan Paik Hospital
2014
Soonchunhyang University
2013
Catholic University of Korea
2013
Chungbuk National University
2006-2007
UDP-glucuronosyltransferase (UGT)–mediated drug–drug interactions are commonly evaluated during drug development. We present a validated method for the simultaneous evaluation of drug-mediated inhibition six major UGT isoforms, developed in human liver microsomes through use pooled specific probe substrates (cocktail assay) and rapid liquid chromatography–tandem mass spectrometry (LC-MS/MS) analysis. The used this assay were estradiol (UGT1A1), chenodeoxycholic acid (UGT1A3), trifluoperazine...
RATIONALE Doping analysis is a two‐step process consisting of screening step for prohibited substances and confirmation to verify the presence specific found during screening. The entire must be performed within limited time period, but traditional procedures commonly employ separate analytical methods each class being screened thus require great deal human resources instrumentation. A single simple rapid multiresidue method that could accommodate multiple classes would extraordinarily...
A simple and accurate liquid chromatography/tandem mass spectrometry (LC/MS/MS) method has been developed validated for the quantitative determination of ephedrine, pseudoephedrine, methylephedrine, cathine, salbutamol, morphine epitestosterone in human urine. Urine samples were spiked with internal standard diluted acetonitrile. After centrifugation, supernatants directly analyzed by LC/MS/MS using selected reaction monitoring (SRM) mode. The linearity, intra- inter-day precision, accuracy,...
Microbially enhanced oil recovery involves the use of microorganisms to extract remaining in reservoirs. Here, we report fabrication microgel particles with immobilized Bacillus subtilis for application microbially recovery. Using B. isolated from oil-contaminated soils Myanmar, evaluated ability this microbe reduce interfacial tension at oil-water interface via production biosurfactant molecules, eventually yielding excellent emulsification across a broad range medium pH and ionic strength....
Flexible tactile sensors have been intensively studied for healthcare and electronic skin devices. Currently, a sensing material, electrode, substrate are manufactured as one set by depositing the material on electrode. For this reason, when another electrode or is used in sensor different characteristics required, new must be developed fabrication conditions should changed. This study proposes novel method of manufacturing pressure like cartridge film. The film made filling holes stencil...
Sarpogrelate is a selective serotonin 5-HT<sub>2A</sub>–receptor antagonist used to treat patients with peripheral arterial disease. This drug rapidly hydrolyzed its main metabolite (<i>R,S</i>)-1-[2-[2-(3–methoxyphenyl)ethyl]phenoxy]-3-(dimethylamino)-2-propanol (M-1), which mainly excreted as glucuronide conjugate. was also directly glucuronidated an <i>O</i>-acyl and <i>N</i>-glucuronide by UDP-glucuronosyltransferases (UGTs) in human liver microsomes (HLMs). Since M-1 pharmacologically...
Ticlopidine is a first-generation thienopyridine antiplatelet drug that prevents adenosine 5′-diphosphate (ADP)-induced platelet aggregation. We identified the enzymes responsible for two-step metabolic bioactivation of ticlopidine in human liver microsomes and plasma. Formation 2-oxo-ticlopidine, an intermediate metabolite, was NADPH dependent cytochrome P450 (CYP) 1A2, 2B6, 2C19, 2D6 were involved this reaction. Conversion 2-oxo-ticlopidine to thiol metabolites observed both (M1 M2) plasma...
Herein, gas-phase polycyclic aromatic hydrocarbons (PAHs) as nonpolar compounds were ionized to protonated molecular ions [M + H]+ without radical cations and simultaneously analyzed using gas chromatography (GC)/electrospray ionization (ESI)-tandem mass spectrometry (MS/MS). The profile, dissociation, sensitivity first investigated understand the significant behavior of PAHs under ESI. formation was distinguished according analyte phase ESI spray solvents. exhibited characteristic...
In this study, a hydrogen/deuterium (H/D) exchange method using gas chromatography-electrospray ionization/mass spectrometry (GC-ESI/MS) was first investigated as novel tool for online H/D of multitarget analytes. The GC and ESI source were combined with homemade heated column transfer line. GC-ESI/MS-based occurs in an atmospheric pressure ion result reacting the gas-phase analyte eluted from charged droplets deuterium oxide infused spray solvent. consumption deuterated solvent at flow rate...
Hypertension is a common condition contributing to many diseases. Factors influencing blood pressure (BP) classification for adults have changed over time. This study aimed identify factors BP according gender.Data from the Sixth Korean National Health and Nutrition Examination Survey (2014) were used in this descriptive, cross-sectional study. Participants 1555 (589 men, 966 women). Measures included demographic, health-related, lifestyle factors.Compared with male normal group,...
Amiodarone is a class III anti-arrhythmic benzofuran derivative extensively utilized in treatment of life-threatening ventricular and supraventricular arrhythmias. However, amiodarone also produces adverse side effects including liver injury due to its metabolites rather than parent drug. The purpose the present study was identify plasma urine rats administered drug by using an untargeted metabolomics approach. Drug were profiled ultra-performance liquid chromatography-linked electrospray...
An ultra-fast generic LC-MS/MS method was developed for high-throughput quantification of discovery pharmacokinetic(PK) samples and its reliability verified. The involves a simple protein precipitation sample preparationand the analysis by with ballistic gradient program selected reaction monitoring (SRM)mode. Approximately 290 new chemical entities (NCEs) (over 10,000 samples) from 5 therapeutic programs were analyzed. calibration curves showed good linearity in concentration range 1, 2 or...
Ki-Hong Kim, Jung-Hyun Shim, Ph.D., Min-Chul Cho, Jeong-Woo Kang, Hyo-Eun Yoon, Do-Young Ph.D. ,Jong-Wan M.D., Dong Ju Son, Jae Woong Lee, Eun Sook Jeong, Jin-Tae Hong, and Dong-Cheul Moon, Ph.D.. Korean J Lab Med 2006;26:185-91. https://doi.org/10.3343/kjlm.2006.26.3.185