A5101921144- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Metabolism, Diabetes, and Cancer
- RNA Interference and Gene Delivery
- Pancreatic function and diabetes
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Viral Infectious Diseases and Gene Expression in Insects
- CRISPR and Genetic Engineering
- Long-Term Effects of COVID-19
- Organ Transplantation Techniques and Outcomes
- Magnesium Oxide Properties and Applications
- Immune Cell Function and Interaction
- Acute Myocardial Infarction Research
- Infective Endocarditis Diagnosis and Management
- Organ and Tissue Transplantation Research
- Innovations in Concrete and Construction Materials
- Recycling and utilization of industrial and municipal waste in materials production
- Acute Ischemic Stroke Management
- Caveolin-1 and cellular processes
- Aortic Disease and Treatment Approaches
- Venous Thromboembolism Diagnosis and Management
National Taipei University of Technology
2024
Columbia University Irving Medical Center
2017-2023
Duke University
2019-2022
Duke Medical Center
2019-2022
Chiang Rai Rajabhat University
2020
Duke University Hospital
2020
New York Hospital Queens
2017
NewYork–Presbyterian Hospital
2017
Mount Sinai Medical Center
2014
Icahn School of Medicine at Mount Sinai
2014
IMPORTANCEThe choice between bioprosthetic and mechanical aortic valve replacement in younger patients is controversial because long-term survival major morbidity are poorly characterized.OBJECTIVE To quantify aged 50 to 69 years undergoing replacement. DESIGN, SETTING, AND PARTICIPANTSRetrospective cohort analysis of 4253 who underwent primary isolated using vs valves New York State from 1997 through 2004, identified the Statewide Planning Research Cooperative System.Median follow-up time...
Abstract Clinically, both percutaneous and surgical approaches to deliver viral vectors the heart either have resulted in therapeutically inadequate levels of transgene expression or raised safety concerns associated with extra-cardiac delivery. Recent developments field normothermic ex vivo cardiac perfusion storage now created opportunities overcome these limitations gene therapy. This study examined feasibility as an approach a vector donor during resulting bio distribution recipient...
Transplantation, the gold standard intervention for organ failure, is a clinical field that ripe applications of gene therapy. One major challenges in applying therapy to this need method achieves consistent and robust delivery allografts. Normothermic
Stroke remains a significant complication of left ventricular assist device (LVAD) therapy. We performed single-center retrospective study evaluating patients undergoing first-time HeartWare HVAD (Medtronic Inc) or HeartMate 3 (Abbott implantation from September 2009-February 2018.Exclusion criteria were age <18 and preoperative ECMO. The primary endpoint was stroke-free survival. defined as new neurological deficits persisting >24 hours with corresponding radiographic evidence. Risk factors...
Specific single-nucleotide polymorphisms in intronic regions of human TCF7L2 are associated with an elevated risk developing type 2 diabetes. Whether Tcf7l2 is expressed pancreatic islets rodent species at a considerable level, however, remains controversial. We used RT-PCR and quantitative to examine expression gut, pancreas, isolated islets, cultured cell lines. The level was relatively lower the pancreas compared gut or β-cell line Ins-1. Immunostaining did not detect signal mouse islets....
Abstract Stroke is a devastating complication of left ventricular assist device (LVAD) therapy. Understanding the characteristics, risk factors and outcomes strokes associated with centrifugal flow LVADs important to devise better strategies for management prevention. This retrospective cohort study at single US academic medical center. The includes patients who received first time Heartmate 3 (HM3) or Heartware (HVAD) LVAD between September 2009 through February 2018 had stroke while was in...
To avoid climate change, the world must reach net-zero carbon emissions by 2025 to achieve goal of a sustainable environment. Improving resource efficiency is one important strategies Effectively recycling resources and reducing energy consumption have become international issues today. Therefore, this research was recycle waste oyster shells, combined it with geopolymer technology, added foaming agents create an innovative building material that 100% recyclable after use – "Foam...
Cardiac transplantation is the gold standard treatment for end-stage heart failure. However, it remains limited by number of available donor hearts and complications such as primary graft dysfunction rejection. The recent clinical use an ex vivo perfusion device in cardiac introduces a unique opportunity treating allografts with therapeutic interventions to improve function avoid deleterious recipient responses. Establishing translational, large-animal model delivery entire allograft...
Central MessageTemporary left ventricular assist device with apical inflow may be safer than veno-arterial membrane oxygenation for supporting patients in cardiogenic shock who had undergone recent mitral valve replacement.See Commentaries on pages 209 and 211. Temporary replacement. See Intracardiac thrombosis (ICT) is a devastating complication of extracorporeal (VA ECMO).1Alhussein M. Moayedi Y. Posada J.D. Ross H. Hickey E. Rao V. et al.Ventricular post-venoarterial oxygenation.Circ...
Cardiac transplantation is the gold standard treatment for end-stage heart failure. However, it remains limited by number of available donor hearts and complications such as primary graft dysfunction rejection. The recent clinical use an ex vivo perfusion device in cardiac introduces a unique opportunity treating allografts with therapeutic interventions to improve function avoid deleterious recipient responses. Establishing translational, large-animal model delivery entire allograft...
Introduction: Stroke is a devastating complication of left ventricular assist device (LVAD) therapy and leading cause mortality in this group. The newer HeartMate (HVAD, 2012) 3 (HM3, 2017) devices use continuous flow centrifugal pump with magnetically levitated rotor that may less thrombosis stroke. We aim to compare the rate severity strokes setting new generation LVADs. Methods: This was single-center retrospective cohort study at single US academic medical center. includes all subjects...
Introduction: Use of gene therapy for cardiac transplantation is limited by the lack an effective recombinant Adeno-associated viral vector (rAAV) delivery strategy. Ex vivo normothermic perfusion has been increasingly used in clinical practice and platform achieving robust global to a donor heart. Here we utilized rationally designed cardiac-enhanced AAV3b variant, SASTG, deliver firefly luciferase porcine hearts evaluated transgene expression 30-days post-transplantation. Methods:...