A5067550428- Neurobiology and Insect Physiology Research
- Genetics, Aging, and Longevity in Model Organisms
- Lepidoptera: Biology and Taxonomy
- Plant Molecular Biology Research
- Insect Utilization and Effects
- Invertebrate Immune Response Mechanisms
- Nutrition, Genetics, and Disease
- Diet and metabolism studies
- Nutritional Studies and Diet
- Circadian rhythm and melatonin
Fred Hutch Cancer Center
2021-2022
University of California, San Diego
2020-2021
University of Washington
2017
Seattle University
2017
In Heliconius butterflies, wing colour pattern diversity and scale types are controlled by a few genes of large effect that regulate switches between morphs species across mimetic radiation. One these genes, cortex, has been repeatedly associated with evolution in butterflies. Here we carried out CRISPR knockouts multiple show cortex is major determinant cell identity. Chromatin accessibility profiling introgression scans identified cis-regulatory regions discrete phenotypic switches....
Aging stem cells lose the capacity to properly respond injury and regenerate their residing tissues. Here, we utilized ability of Drosophila melanogaster germline (GSCs) survive exposure low doses ionizing radiation (IR) as a model adult cell identified regeneration defect in aging GSCs: while GSCs IR, they fail reenter cycle timely manner. Mechanistically, identify foxo mTOR homologue, Tor important regulators GSC quiescence following radiation. is required for entry quiescence, essential...
Diet-induced obesity leads to dysfunctional feeding behavior. However, the precise molecular nodes underlying diet-induced motivation dysregulation are poorly understood. The fruit fly is a simple genetic model system yet displays significant evolutionary conservation mammalian nutrient sensing and energy balance. Using longitudinal high-sugar regime in Drosophila , we sought address how changes adipocyte lipid composition regulate We observed that subjecting adult prolonged diet degrades...
Abstract In Heliconius butterflies, wing pattern diversity is controlled by a few genes of large effect that regulate colour switches between morphs and species across mimetic radiation. One these genes, cortex , has been repeatedly associated with evolution in butterflies. Here we carried out CRISPR knock-outs multiple show major determinant scale cell identity. Chromatin accessibility profiling introgression scans identified cis -regulatory regions discrete phenotypic switches....
Abstract Diet-induced obesity (DIO) leads to dysfunctional feeding behavior. However, the precise molecular nodes underlying diet-induced dysregulation of satiety sensing and motivation are poorly understood. The fruit fly is a simple genetic model system yet displays significant evolutionary conservation mammalian nutrient energy balance. Using longitudinal high sugar regime in Drosophila , we sought address how lipid alteration fat cells alters We find that prolonged exposure HSD degrades...