A5088550652- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Organic Electronics and Photovoltaics
- Conducting polymers and applications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Bioinformatics and Genomic Networks
- Neurological disorders and treatments
- Plasmonic and Surface Plasmon Research
- Extraction and Separation Processes
- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- Genomics and Rare Diseases
- Textile materials and evaluations
- X-ray Diffraction in Crystallography
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Photocatalysis Techniques
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Amyotrophic Lateral Sclerosis Research
- Organic Light-Emitting Diodes Research
- Crystallization and Solubility Studies
- Metal Extraction and Bioleaching
- Genetics and Neurodevelopmental Disorders
- Photonic Crystals and Applications
Leibniz Institute of Polymer Research
2018-2024
TU Dresden
2019-2021
The University of Kitakyushu
2017-2018
University of Hyogo
2018
JTEKT (France)
2014
Kyoto University
2013
Tohoku University
1992-2011
Hiroshima University
2001
Gunma University
1997
Massachusetts General Hospital
1997
Abstract Imprint lithography has emerged as a reliable, reproducible, and rapid method for patterning colloidal nanostructures. As promising alternative to top‐down lithographic approaches, the fabrication of nanodevices thus become effective straightforward. In this study, fusion interference (IL) nanosphere imprint on various target substrates ranging from carbon film transmission electron microscope grid inorganic dopable polymer semiconductor is reported. 1D plasmonic photonic crystals...
The size of the (CAG)n repeat array in 3′ end MJDI gene and haplotype at a series microsateilite markers surrounding MJD1 were examined large cohort Japanese Caucasian subjects affected with Machado-Joseph disease (MJD). Our data provide five novel observations. First, MJD is associated expansion from normal range 14–37 repeats to 68–84 most subjects, but no observed expansions intermediate between those groups. Second, expanded allele displays inter-generational instability, particularly...
Machado-Joseph disease (MJD) is an autosomal dominant multisystem neurodegenerative disorder caused by unstable expansion of a CAG repeat in the MJD1 gene at 14q432.1. To identify elements affecting intergenerational instability repeat, we investigated whether CGG/GGG polymorphism 3′ end affects repeat. The [expanded (CAG)n-CGG]/[normal (CAG)n-GGG] haplotypes were found to result significantly greater compared (CAG)n-CGG] or (CAG)nGGG]/[normal haplotypes. Multiple stepwise logistic...
Abstract The challenges in plasmonic charge transfer on a large‐scale and low losses are systematically investigated by optical designs using 1D‐plasmonic lattice structures. These lattices used as couplers to guide the energy an underneath sub‐wavelength titanium dioxide layer, resulting photonic crystal slabs. So far, photodetection is possible at levels close semiconductor bandgap; however, with observed hybrid plasmonic–photonic modes, other wavelengths over broad solar spectrum can be...
Abstract We report a patient presenting at age 16 years with postural instability and falls who developed severe generalized dystonia by the of 20 years. He was product consanguineous marriage. Maternal grandfather paternal grandmother (brother sister) living in Azores were both affected Machado‐Joseph disease (MJD) beginning late life. To date neither patient's parents are clinically affected. Linkage studies this family others Azorean descent have confirmed recent mapping MJD gene to...
We have discovered a new Italian pedigree with autosomal-dominant ALS. The pedigree, at present, comprises 75 members distributed in five generations. ALS was diagnosed eight patients. mean ± SD age of onset the disease 46.8 13.5 years, range 29 to 63 years. duration 11.6 1.7 months. Molecular genetic studies showed missense mutation (Gly→Ser, codon 41) exon 2 Cu/Zn superoxide dismutase gene (SOD1) on chromosome 21 available affected member and 45% at-risk subjects pedigree. This study...
Abstract Allele frequencies for polymorphisms in the aplipoprotein E and apolipoprotein CII genes were determined subjects of Ashkenazi Jewish origin with lateonset Alzheimer's disease unaffected control from same ethnic group. A significant association was observed between late‐onset ε4 (112 Cys→Arg ) allele E; however, no detected CII. These results suggest that is probably not due to linkage disequilibrium.
Abstract Metal‐semiconductor nanostructures in various configurations are extensively used photodetection, photocatalysis, and photovoltaics. For photodetection purposes, the working principle is straightforward; on illumination, generated charge carriers excess lead to a decrease resistance. Notably, using an interconnected metal‐semiconductor grating, it observed now reported opposite response, increase Such photoresistors fabricated through wrinkle structuring oblique angle material...
The present paper reports the fabrication of novel types hybrid fibrous photocatalysts by combining block copolymer (BCP) templating, sol-gel processing, and coaxial electrospinning techniques. Coaxial produces core-shell nanofibers (NFs), which are converted into hollow porous TiO
Abstract In this study, DNA local structures with bulged bases and mismatched base pairs as well ordinary full‐matched by using 19 F NMR spectroscopy F‐labeled oligodeoxynucleotides (ODNs) were monitored. The chemical shift change in the spectra allowed discrimination of structures. Two types ODNs possessing bis(trifluoromethyl)benzene unit (F‐unit) at specified uridines prepared hybridized their complementary or noncomplementary strands to form matched, mismatched, duplexes. By ODN F1,...
Abstract Here, for the first time, high‐yield (87.6%) robust and facile synthesis of water‐processable donor–acceptor Janus nanoparticles (JNP) that are high potential optoelectronic applications is reported. The JNPs have easily controlled ratios excellent quality, which shown by energy‐filtered transmission electron microscopy. exhibit improved charge separation transfer properties compared to conventional characterized via both steady‐state transient photoluminescence spectroscopy....
Some patients with familial Alzheimer's disease (FAD) have mutations in the presenilin-1 (PS-1) gene on chromosome 14. We report a Japanese family AD and an Ala285Val substitution exon 8 of PS-1 gene. FAD this was characterized by relatively late onset (mean age, 50 years) absence myoclonus, seizures, or paratonia. Levels tau were markedly elevated CSF whereas levels amyloid beta protein normal. MRI cranium showed marked linear signal abnormalities within white matter parieto-occipital...
Abstract The understanding and applications of electron‐conducting π ‐conjugated polymers with naphtalene diimide (NDI) blocks show remarkable progress in recent years. Such demonstrate a facilitated n‐doping due to the strong electron deficiency main polymer chain presence positively charged side groups stabilizing negative charge n‐doped backbone. Here, n‐type conducting NDI enhanced stability its states for prospective “in‐water” is developed. A combined experimental–theoretical approach...
The <i>c-FOS</i> gene product, a putative transacting transcriptional regulator of the amyloid precursor protein (APP) gene, is candidate locus for familial Alzheimer9s disease (FAD) mutation on chromosome 14 (FAD<sub>14</sub>). In light this functional relationship, we investigated nucleotide sequence and segregation <i>of c-FOS</i> 59 APP promoter. Single-stranded conformational polymorphisms (SSCPs) in revealed that closely cosegregates with FAD<sub>14</sub> but does not show allelic...
Abstract A pair of hole‐conducting polymers comprising 3,6‐linked carbazole and meta‐linked anisole derivatives having solubilizing moieties to enable their solution processability, complementarily reactive side‐groups (azide alkyne) for cross‐linking, are synthesized characterized. The can be cross‐linked either by thermal annealing at relatively low temperatures in the 85–110 ° C range, or UV irradiation. general applicability latter a photolithographic patterning hole conducting polymer...