A5101627105- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Medical Imaging Techniques and Applications
- Myasthenia Gravis and Thymoma
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- Cancer Genomics and Diagnostics
- Pituitary Gland Disorders and Treatments
- Cancer-related gene regulation
- Glioma Diagnosis and Treatment
Shanghai Chest Hospital
2011-2021
Shanghai University of Medicine and Health Sciences
2020-2021
Shanghai Jiao Tong University
2014-2021
<sup>18</sup>F-FDG PET has been widely used in the management of malignant tumors. Lactate dehydrogenase A (LDHA) plays an important role development, invasion, and metastasis malignancies. However, relationship between accumulation LDHA expression not investigated. <b>Methods:</b> Retrospective analysis was conducted for 51 patients with lung adenocarcinomas who underwent PET. The maximum standardized uptake value LDHA, glucose transporter 1 (GLUT1), hexokinase 2 (HK2) were examined. RNA...
Abstract Protein kinase B (AKT) hyperactivation and de novo lipogenesis are both common in tumor progression. Sterol regulatory element‐binding protein 1 (SREBP1) is the master regulator for lipid metabolism, arginine methyltransferase 5 (PRMT5) an enzyme that can catalyze symmetric dimethyl (SDMA) modification of mature form SREBP1 (mSREBP1) to induce its hyperactivation. Here, we report SDMA‐modified mSREBP1 (mSREBP1‐SDMA) was overexpressed correlated with Ser473‐phosphorylated AKT...
To determine whether protein kinase C-iota (PKC-iota) is associated with glucose metabolism in non-small-cell lung cancer (NSCLC) and its regulatory effect on metabolic biological changes observed NSCLC can be mediated by transporter 1 (GLUT1).Forty-five patients underwent combined 18F-fludeoxyglucose (18F-FDG) positron emission tomography computed (PET/CT) before surgery, another eighty-one were followed-up for 1-91 months after tumor resection. The rate of was quantified measuring the...