A5086889162- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Organ Transplantation Techniques and Outcomes
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Maternal and fetal healthcare
- Sexual Differentiation and Disorders
- Liver Disease Diagnosis and Treatment
- Reproductive Health and Technologies
- Parvovirus B19 Infection Studies
- Fetal and Pediatric Neurological Disorders
- Maternal and Perinatal Health Interventions
- Hepatitis C virus research
- Ovarian cancer diagnosis and treatment
- Reproductive System and Pregnancy
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- MicroRNA in disease regulation
- Congenital Anomalies and Fetal Surgery
- Hepatocellular Carcinoma Treatment and Prognosis
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
Kobe City Medical Center General Hospital
2024
Sakakibara Hospital
2017-2023
Nagasaki University
2000-2015
Aso Iizuka Hospital
2014
Nishi Niigata Chuo National Hospital
2009
Hiroshima Prefectural Hospital
2009
Jichi Medical University
2007
University of Cincinnati
2002
Suzuka University of Medical Science
2002
University of Chicago
1999-2001
ABSTRACT Objective The aim of this study was to characterize placenta‐specific microRNAs in fetal growth restriction (FGR) pregnancy. Method Placenta‐specific miRNAs were identified by next‐generation sequencing analysis. Subsequently, quantitative real‐time reverse‐transcription polymerase chain reaction used identify FGR whose level expression significantly decreased placenta ( n = 45) compared with uncomplicated 50). pregnancy‐associated, maternal plasma after delivery at concentrations,...
The relationship between male infertility and gr/gr deletions that remove multiple genes of the Y chromosome varies among countries populations. aim this study was to investigate association spermatogenic phenotype in fertile infertile Japanese men. subjects were screened by sequence-tagged site (STS) analysis detect deletions, haplogroups assigned using eight highly informative markers. In total, 395 men 377 (controls) participated our study. Of 772 subjects, 260 individuals carried...
In this report, we present the overall sexual function and clinical features of patients with Klinefelter's syndrome chief complaint male infertility. The study consisted 40 a control group 55 infertile non‐azoospermic males normal 46,XY karyotype who visited Reproduction Center Toho University Hospital during 5.5‐year period between January 1991 June 1996 Among syndrome, 38 cases were pure 47,XXY, one case was 47,XXY pericentric inversion chromosome 9 mosaic 46,XY/47,XXY(2:28). Thirty‐nine...
Abstract Objective The purpose of this study was to investigate whether cell‐free placental mRNA levels have the potential predict a placenta previa resulting in hysterectomy. Methods Twenty‐eight singleton pregnant women with were classified into following four groups: 16 located at posterior part uterine wall (Group A); 4 each anterior without B) or C) previous cesarean section; and other history section who had an underwent hysterectomy D). maternal plasma concentrations lactogen (PL)...
In Brief Objective To evaluate the usefulness of serial transvaginal ultrasonographic measurement thickness lower uterine segment in late second trimester for predicting risk intrapartum incomplete rupture women with previous cesarean delivery. Methods Serial ultrasonography full bladder was performed 374 without delivery (control group) and 348 (cesarean from 19 to 39 weeks' gestation. The measured longitudinal plane cervical canal. Results decreased 6.7 ± 2.4 mm (mean standard deviation...
Abstract The purpose of this study was to know a role confined placental mosaicism (CPM) in perinatal outcome and postnatal growth development infants with intrauterine restriction (IUGR). We selected 50 IUGR (<−2.0 SD) from 3,257 deliveries regional medical center during the past 10‐year period, carried out cytogenetic molecular analyses their placenta cord blood. Of infants, 8 had CPM (CPM group) were composed five single (CPM2, 7, 13, 22, 22), one double (CPM7/13), quadruple trisomy...
To evaluate factors related to the occurrence of Sheehan syndrome.The obstetrical disseminated intravascular coagulation score, total volume hemorrhage, shock index, level consciousness at time and pituitary magnetic resonance imaging findings were evaluated in nine women who showed massive hemorrhage during delivery. These clinical outcomes analyzed all these patients prospectively followed-up identify any possible syndrome.Compared six with non-Sheehan syndrome, three diagnosed syndrome...
We describe a 28 year old male with pseudodicentric Y chromosome who suffered from azoospermia attributed to maturation arrest of the primary spermatocyte, as diagnosed by testicular biopsy. Chromosome analysis, using G, Q and C banding techniques, revealed an abnormal karyotype 45,X[7]/46,X,psu dic (Y)(pter-->q11.2::q11.2-->pter)[33]. Polymerase chain reaction (PCR) DNA analysis did not detect absence DAZ RBM1 which are candidates for azoospermic factor (AZF) genes. Therefore, it is...
This study aimed to investigate the effect of labor on plasma concentrations cell-free, pregnancy-associated, placenta-specific microRNAs (miRNAs) before and after delivery.In non-labor group (32 women), cesarean section (C/S) was performed beginning labor. In C/S Plasma miRNAs (miR-515-3p, miR-517a, miR-517c, miR-518b) were measured by real-time quantitative PCR. Each miRNA concentration compared between groups.Before C/S, in significantly higher than those (P = 0.001 for 515-3p, P 0.002...
The multiplex STS-PCR method was used to detect microdeletions in the long arm of Y chromosome (Yq) cytogenetically normal men. One hundred infertile men with azoospermia or oligozoospermia were screened PCR using 58 STSs, which are specific Yq for detecting on this chromosome. Correlations between and phenotypes spermatogenetic disturbance also examined. Ten patients (10%) had Yq. Seven 60 azoospermic (11.7%), 3 40 oligozoospermic (7.5%) None showed AZFa region, but 2 deletions AZFb another...
Safety winged steel needles were introduced at the University of Tokyo Hospital in January 2001. We studied their effect needlestick injuries. A total 952 and sharp-object injuries reported. From 1999 to December 2004, Cases injury with decreased dramatically soon after safety deviceswere introduced, from 19.8% Apr. -Dec.2000 6.7% 2001 5.5% 2002 (p<.01). They began increase, however, July 2002, again medical staff members mere given lectures notices by e-mail. Due introduction devices, cases...
This study aimed to identify a set of predominantly placental (PP) mRNAs, which are associated with later-developing twin-to-twin transfusion syndrome (TTTS).First, out 50 PP mRNAs we previously reported, select target that ordinarily detectable in maternal plasma. Plasma concentrations these were measured monochorionic diamniotic twin (MCDA-T) pregnancies complicated by TTTS later (n = 11) and uncomplicated MCDA-T 17). Finally, the diagnostic values plasma evaluated.From nine [human...
OBJJECTIVE: To determine the genotypes of four candidate genes in Japanese women with a history preeclampsia, and control group parous woman. STUDY DESIGN: Fifty-two pregnant preeclampsia their first pregnancy 113 normotensive gravid were studied. All subjects singleton gestations. Genomic DNA was extracted, angiotensinogen (AGT), methyleneteterahydofolate reductase (MTHFR), factor ⅤLeiden, prothrombin analyzed. RESULTS: The frequencies homozygous AGT gene mutation MTHFR significantly higher...
The human ALDH3 gene is constitutively expressed in stomach, lung, esophagus, and cornea, but hardly detectable the normal liver. However, it highly activated hepatocellular carcinoma tissues from approximately 50% of patients. nuclear DNA binding factors exist both ALDH3-positive cancerous liver HepG2 cells, not ALDH3-negative Hep3B cells tissues. South-western blot hybridization showed existence two nuclear-binding protein components, 35 14 kDa, These proteins were found stomach KATO III...
Hemorrhage in the third stage of labor is most frequent cause maternal death. A national survey conducted by subcommittee last year revealed following bleeding-related factors during labor: (i) atonic bleeding; (ii) abnormal placental adherence; (iii) adherence plus and (iv) abruption. In short, bleeding important factor associated with massive labor. addition to this, two studies have been this year: secondary investigation clarify pathology frequently occurring bleeding, involving same...