About
Contact & Profiles
A5071498145
Research Areas
- Bone Metabolism and Diseases
- NF-κB Signaling Pathways
- Osteoarthritis Treatment and Mechanisms
Nagasaki University
2020
Runx2 is required for chondrocyte proliferation and maturation. In the search of target genes in chondrocytes, we found that up-regulated expression hematopoietic cell kinase (Hck), which a member Src tyrosine family, Hck was high cartilaginous limb skeletons wild-type mice but low those Runx2–/– mice, bound promoter region Hck. To investigate functions transgenic expressing constitutively active form (HckCA) were generated using Col2a1 promoter/enhancer. The hind fused, tibia became large,...
10.3390/ijms21082682
article
EN
International Journal of Molecular Sciences
2020-04-12
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