A5020711829- Neuroendocrine regulation and behavior
- Pain Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Graphene and Nanomaterials Applications
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Cannabis and Cannabinoid Research
- Carbon and Quantum Dots Applications
- Sleep and Wakefulness Research
- Psychosomatic Disorders and Their Treatments
- Anesthesia and Neurotoxicity Research
- Psychiatric care and mental health services
- Mental Health and Psychiatry
- Graphene research and applications
- Dental Research and COVID-19
- Nicotinic Acetylcholine Receptors Study
- Botulinum Toxin and Related Neurological Disorders
- Periodontal Regeneration and Treatments
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Dental materials and restorations
- Pain Management and Placebo Effect
- Dental Trauma and Treatments
- Neuroscience of respiration and sleep
Scuola Internazionale Superiore di Studi Avanzati
2018-2023
Universitas Islam Indragiri
2019-2020
University of Siena
2019
Universidade de São Paulo
2012-2018
Instituto de Neurociências e Comportamento
2012-2015
Universidade de Ribeirão Preto
2012-2015
Universidade Brasil
2012
The potential anxiolytic and antipanic properties of cannabidiol have been shown; however, its mechanism action seems to recruit other receptors than those involved in the endocannabinoid-mediated system. It was recently shown that model panic-like behaviors elicited by encounters between mice snakes is a good tool investigate innate fear-related responses, causes panicolytic-like effect this model. aim present study 5-hydroxytryptamine (5-HT) co-participation effects on evoked prey versus...
The aim of the present study was to investigate involvement N-methyl-d-aspartate (NMDA) and amino-3-hydroxy-5-methyl-isoxazole-4-proprionate (AMPA)/kainate receptors prelimbic (PL) division medial prefrontal cortex (MPFC) on panic attack-like reactions evoked by γ-aminobutyric acid-A receptor blockade in hypothalamus (MH). Rats were pretreated with NaCl 0.9%, LY235959 (NMDA antagonist), NBQX (AMPA/kainate antagonist) PL at 3 different concentrations. Ten minutes later, MH treated...
Significance Nanotechnology and neurobiology combined efforts might succeed in the design of hybrid microsystems that, once functionally integrated into nervous tissue, help healing injured spinal cord. A substantial challenge this area is development structural scaffolds favoring cord reconstruction. The future success such smart devices resides also use nanomaterials exploiting microenvironment physical properties, as mechanical electrical ones, their potential promoting axonal...
Abstract Defensive responses are neurophysiological processes crucial for survival during threatening situations. immobility is a common adaptive response, in rodents, elaborated by ventrolateral periaqueductal gray matter (vlPAG) when threat unavoidable. It associated with somatosensory and autonomic reactions such as alteration the sensation of pain rate respiration. In this study, defensive was assessed chemical stimulation vlPAG different doses NMDA (0.1, 0.3, 0.6 nmol). After...
The hypothalamus is a forebrain structure critically involved in the organization of defensive responses to aversive stimuli. Gamma-aminobutyric acid (GABA)ergic dysfunction dorsomedial and posterior hypothalamic nuclei implicated origin panic-like behavior, as well pain modulation. present study was conducted test difference between these two regarding antinociceptive mechanisms. Thus, GABA(A) antagonist bicuculline (40 ng/0.2 µL) or saline (0.9% NaCl) microinjected into independent groups....
Engineered small graphene oxide (s-GO) sheets were previously shown to reversibly down-regulate glutamatergic synapses in the hippocampus of juvenile rats, disclosing an unexpected translational potential these nanomaterials target selective vivo. Synapses are anatomical specializations acting Central Nervous System (CNS) as functional interfaces among neurons. Dynamic changes synaptic function, named plasticity, crucial learning and memory. More recently, pathological mechanisms involving...
Nanoscale graphene-based materials (GBMs) enable targeting subcellular structures of the nervous system, a feature crucial for successful engineering alternative nanocarriers to deliver drugs and treat neurodisorders. Among GBMs, graphene oxide (GO) nanoflakes, showing good dispersibility in water solution being rich functionalizable oxygen groups, are ideal core carrying biological active molecules brain, such as neuropeptide Y (NPY). In addition, when unconjugated, these nanomaterials have...
Anxiety disorders (ADs) are nervous system maladies involving changes in the amygdala synaptic circuitry, such as an upregulation of excitatory neurotransmission at glutamatergic synapses. In field nanotechnology, thin graphene oxide flakes with nanoscale lateral size (s-GO) have shown outstanding promise for manipulation neuronal transmission high temporal and spatial precision, thus they were considered ideal candidates modulating amygdalar transmission. Here, we validated vitro model...
Generalised tonic-clonic seizures, generated by abnormal neuronal hyper-activity, cause a significant and long-lasting increase in the nociceptive threshold. The pedunculopontine tegmental nucleus (PPTN) plays crucial role regulation of seizures as well modulation pain, but its postictal antinociceptive processes remains unclear. In present study, we aimed to investigate involvement PPTN neurons antinociception. Wistar rats had their tail-flick baseline recorded were injected with ibotenic...
Synaptic potentiation with increased dendritic spine density is a signature of fear memory consolidation in the lateral amygdala. Small graphene oxide reduces synaptic release and potentiation, preventing increase behaviour.