Afshan Hussain

ORCID: 0000-0003-2983-7210
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About
Contact & Profiles
Research Areas
  • Receptor Mechanisms and Signaling
  • Cardiac Imaging and Diagnostics
  • Coronary Interventions and Diagnostics
  • Acute Myocardial Infarction Research
  • Ectopic Pregnancy Diagnosis and Management
  • Cardiac, Anesthesia and Surgical Outcomes
  • Systemic Lupus Erythematosus Research
  • Atherosclerosis and Cardiovascular Diseases
  • Potassium and Related Disorders
  • Heart Failure Treatment and Management
  • Takotsubo Cardiomyopathy and Associated Phenomena
  • Protein Kinase Regulation and GTPase Signaling
  • Advanced Proteomics Techniques and Applications
  • Cardiovascular Function and Risk Factors
  • Liver Diseases and Immunity
  • Hemodynamic Monitoring and Therapy
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Gynecological conditions and treatments
  • Endometrial and Cervical Cancer Treatments
  • Eicosanoids and Hypertension Pharmacology
  • Diverse Scientific Research Studies
  • Blood disorders and treatments
  • Sepsis Diagnosis and Treatment
  • Reproductive Health and Contraception
  • Celiac Disease Research and Management

Temple University
2013-2022

Dow University of Health Sciences
2017-2022

Civil Hospital Karachi
2017-2022

Our Lady of Fatima University
2022

St. George's University
2022

University of Baghdad
2022

University of Lahore
2022

Fatima Jinnah Medical University
2014

Cerner (United States)
2013

Cleveland Clinic
2011-2013

Curcumin, the primary active ingredient in spice turmeric, was converted to reactive monofunctional derivatives (carboxylic acid/azide/alkyne). The were employed produce a 3 + 2 azide-alkyne "clicked" curcumin dimer and poly(amidoamine) (PAMAM) dendrimer-curcumin conjugate. retain biological activity are efficient for labeling dissolving amyloid fibrils. selectively destroys human neurotumor cells. synthetic methodology developed affords general strategy attaching various macromolecular scaffolds.

10.1021/ol702370m article EN Organic Letters 2007-11-17

Proinflammatory cytokine tumor necrosis factor-α (TNFα) induces β-adrenergic receptor (βAR) desensitization, but mechanisms proximal to the in contributing cardiac dysfunction are not known.Two different proinflammatory transgenic mouse models with overexpression of myotrophin (a prohypertrophic molecule) or TNFα showed that alone is sufficient mediate βAR desensitization as measured by adenylyl cyclase activity. M-mode echocardiography these paralleling independent sympathetic overdrive....

10.1161/circulationaha.113.003183 article EN Circulation 2013-06-20

A short pre-hospital delay, from the onset of symptoms to rapid initiation reperfusion therapy, is a crucial factor in determining prognosis myocardial infarction (MI). The purpose this study was evaluate and presentation delay times MI patients with without diabetes.This cross-sectional conducted 3 tertiary care hospitals Pakistan over period 6 months. sample consisted 280 consenting individuals diagnosed ST-elevation (STEMI) or Non-ST elevation (NSTEMI), out which 130 were diabetic 150...

10.1016/j.ihj.2017.07.013 article EN cc-by-nc-nd Indian Heart Journal 2017-07-27

The current study was conducted to see the frequency of epithelial malignancies endometrium with focus on common diagnostic pitfalls and identify morphological immunohistochemical markers helpful in differential diagnosis between different subtypes. It is a retrospective descriptive carried out 52 specimens endometrial tumors received Fatima Memorial Hospital, Lahore, Pakistan, during three years (2010–2012). Patients were divided into 5 age groups: <40, 41–50, 51–60, 61–70, >70 yrs....

10.1155/2014/179384 article EN cc-by Pathology Research International 2014-01-06

Developmental defects in the Mullerian ducts can result several uterine anomalies including a unicornuate uterus with rudimentary horn. Pregnancy horn is extremely rare occurring 1:76,000-1:160,000 pregnancies. We present case of an 18-year-old primigravida ruptured pregnancy (RHP) presenting as acute abdomen at 17 weeks gestation. Hemodynamic instability led us to perform life-saving emergency laparotomy. A 1.5 liters hemoperitoneum was encountered non-communicating Excision and unilateral...

10.7759/cureus.2591 article EN Cureus 2018-05-08

Patients with lupus nephritis on immunosuppressive therapy are at an increased risk of opportunistic infections. Pneumocystis pneumonia infection though rare, does occur in such patients and is usually missed commonly conducted investigations. Hence physicians must suspect it when clinical signs symptoms do not improve these despite being treatment. a diagnosed case (renal biopsy proven; immunofluorescence microscopy (IMF) showed full house positivity while serum serology revealing decreased...

10.15171/npj.2018.09 article EN cc-by Journal of Nephropharmacology 2017-12-11

Copyright © 2016 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.

10.1097/01.ccm.0000510674.97200.c9 article EN Critical Care Medicine 2016-11-16
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