A5103170455- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Management of metastatic bone disease
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Head and Neck Surgical Oncology
- Voice and Speech Disorders
- Oral health in cancer treatment
- Brain Metastases and Treatment
- Colorectal and Anal Carcinomas
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Dysphagia Assessment and Management
- Yersinia bacterium, plague, ectoparasites research
- Esophageal Cancer Research and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Rabies epidemiology and control
- Radiation Dose and Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Meningioma and schwannoma management
University of Gothenburg
2024
Université Clermont Auvergne
2024
Centre National de la Recherche Scientifique
2024
Centre Hospitalier de l’Université de Montréal
2012-2022
Santé Montérégie
2015-2022
Centre Intégré de Santé et de Services Sociaux des Laurentides
2022
Centre intégré de santé et de services sociaux de Chaudière-Appalaches
2022
Centre intégré de santé et de services sociaux de la Montérégie-Centre
2022
Centre Integre de Sante et de Services Sociaux de Laval
2020-2021
Université de Montréal
2006-2020
Purpose Treatment of oropharyngeal squamous cell carcinoma (OPSCC) is evolving toward risk-based modification therapeutic intensity, which requires patient-specific estimates overall survival (OS) and progression-free (PFS). Methods To develop validate nomograms for OS PFS, we used a derivation cohort 493 patients with OPSCC known p16 tumor status (surrogate human papillomavirus) cigarette smoking history (pack-years) randomly assigned to clinical trials using platinum-based...
Background Radiation Therapy Oncology Group (RTOG)‐0129 recursive partitioning analysis was the basis for risk‐based therapeutic intensification trials oropharyngeal cancer (OPC). To authors’ knowledge, question of whether RTOG‐0129 overall survival (OS) estimates low‐risk, intermediate‐risk, and high‐risk groups are similar in other data sets or applicable to progression‐free (PFS) is unknown. Therefore, authors evaluated differences between risk persist at 5 years, reproducible an...
The efficacy of immunotherapy targeting the PD-1/PD-L1 pathway has previously been demonstrated in metastatic head and neck squamous cell carcinoma (HNSCC). Stereotactic Body Radiotherapy (SBRT) aims at ablating lesions may play a synergistic role with immunotherapy. purpose this study is to assess safety triple treatment combination (TTC) consisting administration durvalumab tremelimumab SBRT HNSCC. This phase I/II single arm that will include 35 patients 2–10 extracranial lesions. Patients...
Radiation to the neck has long been associated with an elevated risk of hypothyroidism development. The goal present work is define dosimetric predictors in oropharyngeal cancer (OPC) patients treated intensity-modulated radiation therapy.Data for 123 patients, a median follow up 4.6 years, were retrospectively analyzed. Patients thyroid-stimulating hormone levels or clinical diagnosis categorized as hypothyroid. Patient demographic parameters, thyroid volume, mean dose, percent volume...
Abstract Data from wildlife disease surveillance programs are used to inform implementation of control (e.g., vaccination, population reduction) in space and time. We developed an approach increase detection raccoon rabies raccoons ( Procyon lotor ) skunks Mephitis mephitis Québec, Canada, we examined the implications using this for targeted surveillance. First modeled probability a rabid animal relative environmental characteristics sampling locations. Rabid animals were more likely be...
The aim of this study is to report outcomes and prognostic factors for early stage non-small cell lung cancer treated with patient-adapted Cyberknife stereotactic body radiotherapy. A retrospective analysis 150 patients T1-2N0 radiotherapy was conducted. An algorithm based on tumor patient’s characteristics used orient towards soft tissue (Xsight Lung), fiducials or adjacent bone Spine) tracking. Median biological effective dose without correction inhomogeneities 180 Gy 10 peripheral tumors...
The aim of this study is to identify clinical factors that are predictive depression and quality life (QOL) among long-term survivors head neck squamous cell carcinoma develop scores using these factors.Cohort studyTertiary referral center.A total 209 posttreatment (median follow-up, 38.7 months) cancer patients were prospectively evaluated the Hospital Anxiety Depression Scale (HADS), European Organization for Research Treatment Cancer (EORTC) Quality Life Questionnaire Core 30, EORTC Head...
Background . RAS gene mutations have an impact on treatment response and overall prognosis for certain types of cancer. Objectives To determine the prevalence K-RAS codons 12 13 in patients with locally advanced HNSCC treated primary or adjuvant chemo-radiation. Methods 428 consecutive were chemo-radiation therapy followed a median 37 months. From these, 199 paraffin embedded biopsy surgical specimens retrieved. DNA was isolated analyzed mutational status. Results extraction successful 197...
Beginning in 2006, point infection control operations and aerial distribution of oral rabies vaccines along the US border were performed Quebec, Canada, to potential spread raccoon rabies. A benefit-cost analysis assessed economic efficiency this programme into future. In study, a mathematical simulation model was used determine from 2006 index case, incidence rates human post-exposure prophylaxis (PEP), animal testing exposure investigations calculated. Benefits calculated as savings...
BACKGROUND: Public health authorities in Quebec have responded to the progressive emergence of Lyme disease (LD) with surveillance activities and education for family physicians (FPs) who are key actors both vigilance case management. OBJECTIVES: To describe FPs’ clinical experience LD, their degree knowledge, practices two areas, one known infected tick populations (Montérégie) without (regions nearby Montérégie). METHODS: In present descriptive cross‐sectional study, FPs were recruited...
Classical radiographic features of patients presenting with silicosis are diffuse interstitial shadowing subsequent enlargement hilar nodes, sometimes "eggshell" calcification. Five case histories described workers who were exposed to silica and presented initially bilateral lymphadenopathy without evidence lung disease. One progressed show silicosis.
Surgery remains the standard treatment for medically operable patients with early-stage non-small cell lung carcinoma (NSCLC). Following surgical resection, adjuvant chemotherapy is recommended large tumors >4 cm. For unfit patients, stereotactic body radiation therapy (SBRT) has emerged as an excellent alternative to surgery. This study aims assess patterns of recurrence and discuss role after SBRT NSCLC.We reviewed treated primary NSCLC between 2009 2015. Total target doses were 50 60 Gy...
Mitochondrial single-stranded DNA-binding protein (mtSSB) is essential for mitochondrial DNA (mtDNA) replication. Recently, several mtSSB variants have been associated with autosomal dominant optic atrophy and retinal dystrophy. Here, we studied at the molecular level functional consequences of one most severe variants, R107Q. We first oligomeric state this variant observed that mtSSBR107Q mutant forms stable tetramers in vitro. On other hand, showed, using complementary single-molecule...
Purpose Radiation therapy (RT) has been a frequently used treatment for painful bone metastasis. The aim of this study was to determine the feasibility using activity trackers (AT) assess patient prognosis and effects palliative RT. Methods materials Twelve patients planned receive RT axial metastases were prospectively recruited participate in pilot clinical trial. eligible if there no intent change analgesic medications prior or within seven days All lent Misfit FlashTM tracker (Misfit,...