A5062865460- Connexins and lens biology
- Intraocular Surgery and Lenses
- Neuroscience and Neuropharmacology Research
- Corneal surgery and disorders
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Spectroscopy Techniques in Biomedical and Chemical Research
- Ophthalmology and Visual Impairment Studies
- Barrier Structure and Function Studies
- Retinal Diseases and Treatments
- Advanced Glycation End Products research
- Retinal and Macular Surgery
- Biochemical effects in animals
- Urinary Bladder and Prostate Research
- Neurobiology and Insect Physiology Research
- Bee Products Chemical Analysis
- Ocular and Laser Science Research
- Alzheimer's disease research and treatments
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Angiogenesis and VEGF in Cancer
Leiden University Medical Center
2006-2017
Leiden University
1988-2013
University of Antwerp
2005
Combined Ophthalmic Research Rotterdam
1994-2003
Morpho (United States)
1994-2002
Massachusetts Eye and Ear Infirmary
2000
Graduate School Neurosciences Amsterdam Rotterdam
1997
Netherlands Institute for Neuroscience
1995
University of Twente
1994
University of Dundee
1994
A confocal Raman microscope is used to study the protein distribution inside biological cells. It shown that high quality imaging of can be obtained using nonresonant (lambda(exc) = 647.1 nm). The results are for two different human cell types. Perpheral blood lymphocytes as an example fully maturated cells with a low level nuclear transcription. Human eye lens epithelial activity. in both types completely different. largely varies peripheral lymphocyte cells, while proteins more...
Abstract Vascular endothelial growth factor receptor 3 (VEGFR‐3, Flt‐4), the for vascular factors (VEGFs) C and D, is expressed on lymphatic endothelium may play a role in lymphangiogenesis. In embryonic life, VEGFR‐3 essential blood vessel development. The purpose of this study was to investigate whether also involved angiogenesis adult. This studied human tissues showing andin model VEGF‐A‐induced iris neovascularization monkey eye, by use immunohistochemistry at light electron microscopic...
The vascular endothelial growth factor (VEGF) family is involved in angiogenesis, and therefore VEGFs are considered as targets for anti-angiogenic therapeutic strategies against cancer. However, the physiological functions of quiescent tissues unclear may interfere with such systemic therapies. In pathological conditions, increased levels expression VEGF receptors VEGFR-1, VEGFR-2, VEGFR-3 accompany activity. this study we investigated normal human monkey patterns these receptors....
AbstractPurpose. In tissues outside the brain, vascular endothelial growth factor-A (VEGF) causes hyper-permeability by opening of inter-endothelial junctions and induction fenestrations vesiculo-vacuolar organelles (VVOs). preliminary studies, we observed that in blood-retinal barrier endothelium, other cellular mechanisms may underlie increased permeability caused VEGF. This was further investigated material an vivo experimental model VEGF-induced retinopathy. Methods. Two monkeys received...
To report a new intraocular lens (IOL) and an IOL implantation concept, the bag-in-the-lens technique, designed to prevent posterior capsule opacification (PCO).The University of Antwerp, Department Ophthalmology, Edegem, Belgium, Netherlands Ophthalmic Research Institute, Morphology, Amsterdam, The Netherlands.After identical curvilinear capsulorhexes are created in both anterior capsules, capsules inserted flange IOL, thus term bag-in-the-lensas opposed currently used...