A5105511259- Vestibular and auditory disorders
- Mosquito-borne diseases and control
- Ophthalmology and Eye Disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Autoimmune Neurological Disorders and Treatments
- Viral Infections and Vectors
- Glaucoma and retinal disorders
- RNA Research and Splicing
- Ear Surgery and Otitis Media
- Genetic Neurodegenerative Diseases
- Cerebral Venous Sinus Thrombosis
- Cardiovascular Syncope and Autonomic Disorders
- Nitric Oxide and Endothelin Effects
- Glycosylation and Glycoproteins Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Lysosomal Storage Disorders Research
- Herpesvirus Infections and Treatments
- Hereditary Neurological Disorders
- Electrolyte and hormonal disorders
- Signaling Pathways in Disease
- Inflammatory Myopathies and Dermatomyositis
- Neuroendocrine regulation and behavior
- Obstructive Sleep Apnea Research
- Head and Neck Surgical Oncology
- Sarcoidosis and Beryllium Toxicity Research
Nagaoka Red Cross Hospital
2016-2025
Osaka Kaisei Hospital
2020-2024
Nara Medical University
2004-2020
Tochigi Medical Center
2020
Nippon Medical School Hospital
2019
Nippon Life Hospital
2017-2018
Saiseikai Utsunomiya hospital
2008-2017
National Archives and Records Administration
1988-2016
Nara Prefecture General Medical Center
2016
Medical University of Vienna
2010
The four established or putative sphingolipid activator proteins derive from a large precursor protein encoded by single gene. In addition to generating the proteins, is suspected of having functions its own, as, for example, lipid binding/transport neurotrophic factor. gene also appears encode Sertoli cell major sulfated glycoprotein. Sequence similarities have been noted with many other diverse functions. One patient and fetus in family complete defect this due mutation initiation codon...
We determined whether aquaporin of collecting duct (AQP-CD) is involved in pathogenesis water retention rats with experimental models syndrome inappropriate secretion antidiuretic hormone (SIADH) and liver cirrhosis. SIADH were made by administering 1-desamino-8-D-arginine vasopressin (DDAVP) subcutaneously providing them a liquid diet. Serum Na levels decreased to < 120 meq/l on day 2, hyponatremia persisted throughout the rest observation period. Six hours after DDAVP infusion, expression...
Abstract We report a homozygous case of spinocerebellar ataxia type 17 with 48 glutamines. The age the patient at disease onset was not lower than those heterozygotes same CAG‐repeat sizes, but clinical manifestations were rapidly progressive dementia and chorea. Neuronal loss relatively restricted most prominent in Purkinje cell layer striatum; however, intranuclear neuronal polyglutamine accumulation widespread, high frequency cerebral cortex striatum.
Objectives/Hypothesis Benign paroxysmal positional vertigo (BPPV) frequently occurs in females over 50 years old, suggesting that a postmenopausal decrease estrogen secretion might be involved its onset . An deficiency is generally known to cause osteoporosis through reduction bone mass. This study was designed investigate clinical association between idiopathic BPPV and osteoporosis. Study Design Case‐control study. Methods We measured the mineral density (BMD) at lumbar vertebrae 61...
The myelin-associated glycoprotein (MAG) is a member of the immunoglobulin gene superfamily and thought to play critical role in interaction myelinating glial cells with axon. Myelin from mutant mice incapable expressing MAG displays various subtle abnormalities CNS degenerates age peripheral nervous system (PNS). Two distinct isoforms, large (L-MAG) small (S-MAG), are produced through alternative splicing primary transcript. cytoplasmic domain L-MAG contains unique phosphorylation site has...
Dehydration increased the expression of aquaporin collecting duct (AQP-2) and translocated AQP-2 to apical plasma membranes from cytoplasmic vesicles cells. We determined whether abrupt decrease in circulating arginine vasopressin (AVP) by giving excess water affects mRNA subcellular localization cells dehydrated rats. The 72-h deprivation AVP levels 3.1 pg/ml 336% rats, which were concomitantly abolished 40 ml/kg oral load. A 50% inhibition ofAQP-2 was obtained with 20 min after forced In...
Evidence is presented that expression of the two myelin‐associated glycoprotein mRNAs developmentally regulated in mouse brain. In quaking mouse, mRNA without a 45‐nucleotide exon portion was scarcely expressed throughout development. We conclude mechanism splicing out lacking mouse.
We report the histopathological features of vertebral basilar system dolichoectasia (VBD) in a 68‐year‐old man who died as result accompanying infarction medulla oblongata on day 6 admission. During hospitalization, patient was also found to have an elevated serum IgG level and tumors renal pelvis. A possible clinical diagnosis VBD associated with IgG4‐related disease considered postmortem. Autopsy examination, limited intracranial tissues, revealed marked infiltration IgG4‐containing plasma...
Long-term exposure of uninephrectomized rats to desoxycorticosterone acetate (DOCA)/salt induces cardiac fibrosis and hypertrophy through mineralocorticoid receptors (MRs). However, the underlying cellular mechanisms remain unclear. To determine whether Na/H exchange isoform 1 (NHE1) is involved in mechanisms, we examined effects a specific NHE1 inhibitor, cariporide, an MR antagonist, spironolactone, on DOCA/salt-induced hypertrophy. Uninephrectomized were given 20 mg DOCA (single...
Abstract: Two polypeptide isoforms of myelin‐associated glycoprotein (MAG) with molecular masses 72 and 67 kDa are produced by alternative splicing the exon 12 portion. Our previous work has demonstrated that in quaking mouse brain this is lacking mRNA coding large MAG isoform (L‐MAG) scarcely expressed, whereas small (S‐MAG) overexpressed. In present study, we prepared antisera specific to S‐MAG L‐MAG amino acid residues, respectively. Immunoblots showed band was detectable brain, had an...
Quaking is an autosomal recessive hypo/dysmyelinating mutant mouse which has a 1-Mbp deletion on chromosome 17. The mutation exhibits pleiotrophy and does not include genes encoding characterized myelin proteins. levels of the 67-kD isoform myelin-associated glycoprotein (S-MAG) relative to those 72-kD (L-MAG) are increased in quaking CNS, but other dysmyelinating mutants. Abnormal expression MAG isoforms may result from altered transcription gene or abnormal sorting, transport, targeting...
The present study was undertaken to determine the pathophysiological role of arginine vasopressin (AVP) in elderly patients with hyponatremia, and efficacy fludrocortisone acetate treating their hyponatremia. Eleven hospitalized aged 65 years or older whose serum sodium levels were less than 130mEq/l examined. hyponatremic included two groups patients: syndrome inappropriate secretion antidiuretic hormone (SIADH) central salt-wasting syndrome. And 24 healthy, young subjects 20 34 years, 80...
Objectives/Hypothesis Metabolic syndrome (MetS) is a condition that increases the risk of coronary artery disease and cerebral infarction. We determined prevalence MetS in vertigo patients clinically investigated association between vertigo. Study Design Case-control study Methods The subjects were 333 patients, including 107 males 226 females, who presented with as primary symptom. was diagnosed according to International Diabetes Federation definition, which based on waist circumference,...