A5007663616- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Ion Channels and Receptors
- Erythropoietin and Anemia Treatment
- Esophageal and GI Pathology
- Cardiac Arrhythmias and Treatments
- Myasthenia Gravis and Thymoma
- Peripheral Neuropathies and Disorders
- Ion channel regulation and function
- Cardiomyopathy and Myosin Studies
- Cardiovascular and exercise physiology
- Hemodynamic Monitoring and Therapy
- Eosinophilic Esophagitis
- Hereditary Neurological Disorders
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Congenital Heart Disease Studies
- Liver Disease and Transplantation
- Iron Metabolism and Disorders
- Neurobiology and Insect Physiology Research
- Coronary Interventions and Diagnostics
- Nonmelanoma Skin Cancer Studies
Hokkaido University
2010-2024
Tokyo Women's Medical University
2008-2012
Dokkyo Medical University
2010
Showa Pharmaceutical University
2004-2005
Tsukuba Memorial Hospital
1989
University of Tsukuba Hospital
1989
Abstract Aims Iron deficiency (ID) is a common co‐morbidity in patients with heart failure (HF). A recent study showed that ID defined by the current guideline criteria was not associated worse clinical outcomes, and new proposed HF. However, external applicability of unclear. We sought to investigate Japanese Methods results prospectively examined 763 chronic HF from multicentre registry. The were transferrin saturation (TSAT) < 20% serum iron ≤13 mmol/L ferritin <100 ng/mL or, when...
Receptor-operated Ca<sup>2+</sup> entry (ROCE) via transient receptor potential canonical channel 6 (TRPC6) is important machinery for an increase in intracellular concentration triggered by the activation of G<sub>q</sub> protein-coupled receptors. TRPC6 phosphorylated various protein kinases including kinase A (PKA). However, regulation activity PKA still controversial. The purpose this study was to elucidate role adenylate cyclase/cAMP/PKA signaling pathway endothelin type...
BACKGROUND: Accurate assessment of left ventricular filling pressure in patients with atrial fibrillation or flutter (AF) remains difficult. A novel 2-dimensional scoring system, visually assessing time difference between mitral valve and tricuspid opening (VMT) score, based on temporal analysis early diastolic opening, could be applied to these patients. We aimed determine the usefulness VMT score AF. METHODS: analyzed 119 consecutive AF who underwent cardiac catheterization as a derivation...
Abstract Background The assessment of left ventricular (LV) filling pressure (FP) is important for the management aortic stenosis (AS) patients. Although, it often restricted predict LV FP in AS because mitral annular calcification and a certain hypertrophy. Thus, we tested predictive ability algorithm elevated patients also applied recently‐proposed echocardiographic scoring system FP, visually assessed time difference between valve tricuspid opening (VMT) score. Methods We enrolled...
Elevated left ventricular filling pressure (LVFP) is a powerful indicator of worsening clinical outcomes in heart failure with preserved ejection fraction (HFpEF); however, detection elevated LVFP often challenging. This study aimed to determine the association between newly proposed echocardiographic parameter, visually assessed time difference mitral valve and tricuspid opening (VMT) score, HFpEF.We retrospectively investigated 310 well-differentiated HFpEF patients stable conditions. VMT...
The long-term effects of hydrocortisone (HDC) used for very-low-birthweight (VLBW) infants with chronic lung disease (CLD) are not fully understood. aim this study was to examine the short-term clinical and impact a physiological replacement dose HDC on acute deterioration CLD in VLBW infants.This prospective case-control included 110 174 admitted our facility between 2003 2006 who were followed up corrected age 18 months. Infant deaths congenital deformities excluded from study. classified...
Although the left ventricular (LV) dysfunction in pre-capillary pulmonary hypertension (PH) has been recently recognized, mechanism of LV this entity is not completely understood. We thus aimed to elucidate determinants intraventricular pressure difference (IVPD), a measure suction, PH.Right heart catheterization and echocardiography were performed 86 consecutive patients with PH (57 ± 18 years, 85% female). IVPD was determined using colour M-mode Doppler integrate Euler equation. In...
Blood flow in the hepatic veins and superior vena cava (SVC) reflects right heart filling; however, their Doppler profiles are often not identical, no studies have compared diagnostic efficacies. We aimed to determine which venous profile is reliable for detecting elevated atrial pressure (RAP).
We herein report the first case of constrictive pericarditis (CP) induced by long-term pergolide treatment for Parkinson's disease that was assessed using multimodal imaging in a 72-year-old patient with leg edema and dyspnea. The correctly diagnosed CP successfully treated pericardiectomy. history pathological findings removed pericardium suggested cause CP. Properly recognizing as accurately diagnosing may contribute to early detection pergolide-induced
Background: Anemia is frequently observed in patients with chronic heart failure (CHF), and many studies have evaluated the association between anemia mortality CHF. The quality of erythropoiesis an intrinsic aspect pathophysiology anemia, ability reticulocyte production would be one pivotal factors erythropoiesis. However, it remains unclear whether associated clinical outcomes Methods: We prospectively examined 1,274 symptomatic CHF (mean age 71.9±13.4 years, median LVEF 50 [IQR 36-63]%) a...