A5015976509- Autophagy in Disease and Therapy
- Polymer Surface Interaction Studies
- Hepatitis B Virus Studies
- Endoplasmic Reticulum Stress and Disease
- Advanced Polymer Synthesis and Characterization
- Heme Oxygenase-1 and Carbon Monoxide
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Alcoholism and Thiamine Deficiency
- Single-cell and spatial transcriptomics
- Diatoms and Algae Research
- Lung Cancer Treatments and Mutations
- Alzheimer's disease research and treatments
- Heat shock proteins research
- Pharmacogenetics and Drug Metabolism
- DNA Repair Mechanisms
- Dementia and Cognitive Impairment Research
- MicroRNA in disease regulation
- Immune cells in cancer
- CRISPR and Genetic Engineering
- Ovarian cancer diagnosis and treatment
- Helicobacter pylori-related gastroenterology studies
- Cancer-related Molecular Pathways
- Adipose Tissue and Metabolism
- Cell death mechanisms and regulation
- Hepatitis C virus research
Taoyuan Chang Gung Memorial Hospital
2019-2020
Chang Gung University
2019-2020
National Yang Ming Chiao Tung University
2019
Chang Gung Memorial Hospital
2015
National Cheng Kung University
2005-2014
Genomics Research Center, Academia Sinica
2012
University of California, Irvine
2012
Abstract The hepatitis B virus (HBV) large surface antigen (LHBS) mutant with deletion at the pre-S2 region accumulates in endoplasmic reticulum (ER) and is associated HBV-induced hepatocellular carcinogenesis. In this study, we found that LHBS directly interacts Jun activation domain–binding protein 1 (JAB1). Association of JAB1 dissociated from JAB1/IRE1 complex ER. free (active) then translocated into cell nuclei rendered Cdk inhibitor p27Kip1 to cytosolic proteasome for degradation....
Abstract Background Chronic hepatitis B virus (HBV) infection is an important cause of hepatocellular carcinoma (HCC) worldwide. The pre-S 1 and -S 2 mutant large HBV surface antigen (LHBS), in which the regions LHBS gene are partially deleted, highly associated with HBV-related HCC. Methods region two hundred one HBV-positive serum samples was PCR-amplified sequenced. A oligonucleotide chip developed to efficiently detect deletions chronic carriers. Twenty from carriers were analyzed using...
Chronic hepatitis B virus (HBV) infection is the major cause of hepatocellular carcinoma (HCC). The pre-S 2 mutant large HBV surface antigen (LHBS) in type II ground glass hepatocytes (GGHs) has been recognized as an emerging viral oncoprotein; it directly interacts with c-Jun activation domain-binding protein 1 (JAB1) and subsequently causes hyperphosphorylation tumor-suppressor retinoblastoma and, consequently, leads to disturbed cell cycle progression. interaction LHBS JAB1 could provide...
We report the versatility of polyion complex (PIC) micelles for preparation shell and core cross-linked (SCL CCL) with their surface properties determined by constituent polymer composition cross-linking agent. The negatively positively charged PIC molecular structure depending on mixing weight percentage were first prepared polyions, poly(acrylic acid) (PAA) poly(L-lysine) (PLL). feasibility preparing SCL was demonstrated using cystamine genipin, respectively. can be silica deposition to...
Abstract Background To facilitate the investigation of pathogenic roles played by various immune cells in complex tissues such as tumors, a few computational methods for deconvoluting bulk gene expression profiles to predict cell composition have been created. However, available were usually developed along with set reference consisting imbalanced replicates across different types. Therefore, objective this study was create new deconvolution method equipped that incorporate more microarray...
(1) Background: The potential of old drugs in novel indications is being greatly valued. We propose a triple-model study involving population-based, cell, and animal studies to investigate the effects risperidone, type second-generation antipsychotic (SGA) drug, on colorectal cancer. (2) Methods: used data from Taiwan’s National Health Insurance Research Database between 1997 2013 compare 101,989 patients with cancer controls. Conditional logistic regression analyses were explore association...
Objective Patients with late-onset depression (LOD) have been reported to run a higher risk of subsequent dementia. The present study was conducted assess whether statins can reduce the dementia in these patients. Methods We used data from National Health Insurance Taiwan during 1996–2009. Standardized Incidence Ratios (SIRs) were calculated for LOD and criteria diagnoses included age ≥65 years, diagnosis after 65 years age, at least three service claims, treatment antidepressants....
Abstract Objective The association between antipsychotic use and gastric cancer risk remains unclear. Therefore, this study aimed to determine the exposure incidence of cancer. Methods Using a nested case‐control design, total 34 470 patients 163 430 nongastric controls were identified from Taiwan's National Health Insurance Research Database 1 January 1997 31 December 2013. We analyzed data using conditional logistic regression model adjust for possible confounding variables. Results...