A5002782975- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Breast Cancer Therapies
- Dementia and Cognitive Impairment Research
- Metastasis and carcinoma case studies
- Head and Neck Cancer Studies
- Medical Imaging Techniques and Applications
- Artificial Intelligence in Healthcare and Education
- Lung Cancer Research Studies
- Chronic Disease Management Strategies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Research and Treatments
- Colorectal Cancer Treatments and Studies
- Ultrasound and Hyperthermia Applications
- Chemokine receptors and signaling
- Cholinesterase and Neurodegenerative Diseases
- Urologic and reproductive health conditions
- Healthcare Technology and Patient Monitoring
- Genetic and Kidney Cyst Diseases
- Meta-analysis and systematic reviews
- Multiple Myeloma Research and Treatments
- Pleural and Pulmonary Diseases
University Medical Center Freiburg
2023-2025
University of Freiburg
2022-2025
Klinikum Chemnitz
2024
Iomedico (Germany)
2016-2021
To evaluate the role of different invasive and non-invasive mediastinal staging methods in patients with locally advanced non-small-cell lung cancer (NSCLC) treated definitive chemoradiotherapy prospective XXX trial (XXX; NCTXXX) to impact endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) mediastinoscopy on target volume definition. Patients per-protocol (n = 172), all receiving isotoxically dose-escalated chemoradiotherapy, were included this unplanned secondary...
NOX-A12 is a PEGylated mirror-image oligonucleotide (a so-called Spiegelmer) that binds to CXCL12 (stromal cell–derived factor-1, SDF-1) with high affinity thereby inhibiting signaling on both its receptors, CXCR4 and CXCR7. In animals, mobilized white blood cells (WBCs) hematopoietic stem progenitor (HSCs) into peripheral (PB). healthy volunteers, single doses of had benign safety profile also dose-dependently WBCs HSCs PB. HSC peak mobilization reached plateau at five times the baseline...
An increasing number of treatment-determining biomarkers has been identified in non-small cell lung cancer (NSCLC) and molecular testing is recommended to enable optimal individualized treatment. However, data on implementation these recommendations the "real-world" setting are scarce. This study presents comprehensive details frequency, methodology results biomarker advanced NSCLC Germany.This analysis included 3,717 patients with (2,921 non-squamous; 796 squamous), recruited into CRISP...
The utility of amyloid positron emission tomography (PET) for the etiological diagnosis dementia and its impact on functional status patients in routine care are currently unclear. Here, we describe design ENABLE, a randomized controlled two-armed coverage with evidence development (CED) study Germany. Approximately 1126 mild to moderate unclear etiology will be randomly assigned either an PET or no group. Patients followed-up 24 months. has been registered at German Clinical Trials Register...
Since 2021, international guidelines for cardiopulmonary resuscitation recommend the implementation of so-called "life-saving systems". These systems include smartphone alerting (SAS), which enable dispatch centres to alert first responders via applications, who are in proximity a suspected out-of-hospital cardiac arrest (OHCA). However, effect SAS on survival remains unknown. The aim is assess rate hospital discharge adult patients with OHCA not witnessed by emergency medical services...
A higher estimated dose of radiation to immune cells (EDRIC) has been proposed as an explanation for failed attempts at thoracic intensification a part concurrent chemoradiotherapy (cCRT) locally advanced non-small-cell lung cancer (NSCLC), lymphopenia in particular is negative prognostic factor this context. We studied the impact EDRIC on survival secondary analysis prospective PET-Plan trial (ARO-2009-09; NCT00697333). Considering system organ risk radiotherapy major importance current era...
Background: Infantile hemangiomas (IH) are the most common benign vascular tumor in infants. Despite their spontaneous regression, IH can cause aesthetic, functional, and vital organ complications. Hepatic involvement requires particular attention infants with multiple cutaneous hemangiomas. While magnetic resonance imaging (MRI) is established diagnostic standard, contrast-enhanced ultrasound (CEUS) emerges as a promising alternative. Objective: To compare accuracy of CEUS MRI hepatic...
We conducted an open-label, randomized, two-arm multi-center study to assess the efficacy and safety of paclitaxel versus + sorafenib in patients with locally advanced or metastatic HER2-negative breast cancer. Patients were randomly assigned receive either monotherapy (80 mg/m2) weekly (3 weeks on, 1 week off) plus 400 mg orally, twice a day taken continuously throughout 28 cycles. Sorafenib dose was gradually escalated from starting 200 day. The primary endpoint progression free survival...
To ascertain the tolerability profile of single and repeated oral doses methanesulfonyl fluoride (MSF, SNX-001) in healthy aged subjects, to determine degree erythrocyte acetylcholinesterase (AChE) inhibition induced by MSF after doses.To calculate properly kinetics duration AChE inhibition, effects were also studied rodents. These experiments suggested that administered three times per week should provide safe efficacious inhibition. In a randomized placebo-controlled phase I study, 3.6 mg,...
e21236 Background: Treatment in non-small cell lung cancer is quickly evolving and new agents make it to the routine practice at a rapid pace. It of high interest patients (pts), physicians reimbursement institutions investigate how outcomes from clinical trials translate into practice. Methods: The prospective, national research platform CRISP recruits pts currently 144 representative centres all therapeutic sectors Germany. More than 8000 will be recruited followed until death or up...
Abstract: Both architectural and cytologic characteristics are used to distinguish benign from malignant sebaceous neoplasms; however, specific cytopathologic features of sebocytes have not been well defined. The authors assessed cytological 63 neoplasms [15 hyperplasias, 12 sebaceomas, 16 adenomas (SA), 14 carcinomas (SC), 6 ocular carcinoma (OSC)] investigate whether grading may facilitate classification lesions. Among other criteria, nuclear pleomorphism (size, nucleolar appearance,...
Introduction Breast cancer is globally the leading in women, and despite high 5-year survival rate most frequent cause of related deaths. Surgery, systemic therapy radiotherapy are three pillars curative breast treatment. However, locoregional recurrences frequently occur after initial treatment often challenging to treat, amongst others due doses previous treatments. Radiotherapy can be combined with local hyperthermia sensitize tumor cells radiation thereby significantly reduce required...
TPS9108 Background: Treatment in NSCLC is quickly evolving. Whether outcome and PRO data generated clinical trials with narrow inclusion exclusion criteria will hold up the routine practice of high interest, especially due to increasing costs new drugs. Therefore registry are importance patients, physicians third parties. This why we have started a prospective, for patients metastatic non-small cell lung cancer. Methods: The purpose CRISP set national research platform document...
Abstract Background Artificial intelligence (AI) has experienced an explosive growth in the healthcare sector and scientific field. Large Language Models (LLMs) are investigated as potential tool to be used medical treatment, by e.g. producing doctor’s reports, supporting personalized medicine or educating patients. However, limitations broadly discussed addressing patient safety ethical concerns due false misleading content. Therefore, LLMs face criticism among users not only towards their...
Background The advancement of Artificial Intelligence, particularly Large Language Models (LLMs), is rapidly progressing. LLMs, such as OpenAI’s GPT, are becoming vital in scientific and medical processes, including text production, knowledge synthesis, translation, patient communication data analysis. However, the outcome quality needs to be evaluated assess full potential for usage statistical applications. LLMs show all research areas, teaching. Integrating research, education care poses...
Abstract Purpose Staging of non-small cell lung cancer (NSCLC) is commonly based on [ 18 F]FDG PET/CT, in particular to exclude distant metastases and guide local therapy approaches like resection radiotherapy. Although it hoped that PET/CT will increase the value primary staging compared conventional imaging, generally limited characterization TNM. The first aim this study was evaluate PET parameter metabolic tumor volume (MTV) above liver background uptake as a prognostic marker cancer....
Abstract Background Amyloid PET imaging is an established diagnostic tool for Alzheimer's disease, but its successful integration into clinical practice requires a comprehensive understanding of impact on patients and the healthcare system. In 2022, coverage with evidence development (CED) ENABLE study has been approved by German Federal Joint Committee (trial registration: DRKS00030839). The scheduled to start in early 2024. Primary outcome change patients' functional abilities at 18 months...
Abstract Background Amyloid PET imaging is an established diagnostic tool for Alzheimer’s disease, but its successful integration into clinical practice requires a comprehensive understanding of impact on patients and the healthcare system. In 2022, coverage with evidence development (CED) ENABLE study has been approved by German Federal Joint Committee (trial registration: DRKS00030839). The scheduled to start in early 2024. Primary outcome change patients' functional abilities at 18 months...