A5011039308- Orthopedic Infections and Treatments
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Metabolism and Genetic Disorders
- Neonatal Health and Biochemistry
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pediatric Hepatobiliary Diseases and Treatments
- Orthopaedic implants and arthroplasty
- Antimicrobial agents and applications
- Mitochondrial Function and Pathology
Massachusetts General Hospital
2023-2025
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
2019-2021
Harvard University
2019-2021
Boston Children's Hospital
2019-2021
Abstract Background While antibiotics remain our primary tools against microbial infection, increasing antibiotic resistance (inherent and acquired) is a major detriment to their efficacy. A practical approach maintaining or reversing the efficacy of use other commonly used therapeutics, which show synergistic antibacterial action with antibiotics. Here, we investigated extent synergy between gentamicin anti-inflammatory ketorolac regarding dynamics biofilm growth, rate acquired resistance,...
Peri-prosthetic joint infection (PJI) is a major post-arthroplasty complication that warrants alternative antibacterial approaches to improve prophylaxis and treatment outcomes. Local administration of analgesics post-surgery common. Recent studies have demonstrated the antimicrobial potential feasibility dual drug-eluting ultra-high molecular weight polyethylene (UHMWPE) for local applications. However, mechanism action poorly understood, translational value drug-loaded UHMWPE has not been...
Abstract Background While antibiotics remain our primary tools against microbial infection, increasing antibiotic resistance (inherent and acquired) is a major detriment to their efficacy. A practical approach maintaining or reversing the efficacy of use other commonly used therapeutics, which show synergistic antibacterial action with antibiotics. Here, we investigated extent synergy between gentamicin anti-inflammatory ketorolac regarding dynamics biofilm growth, rate acquired resistance,...