A5042263296- Pulmonary Hypertension Research and Treatments
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Cardiac Imaging and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Respiratory Support and Mechanisms
- Heart Failure Treatment and Management
- Long-Term Effects of COVID-19
- Congenital Heart Disease Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammatory mediators and NSAID effects
- Acute Myocardial Infarction Research
- Vascular Anomalies and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neonatal Respiratory Health Research
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Issues in Pregnancy
- Lipoproteins and Cardiovascular Health
- Airway Management and Intubation Techniques
- Inflammasome and immune disorders
- Cardiac Health and Mental Health
- Finance, Taxation, and Governance
Hospital Universitario 12 De Octubre
2022-2024
Research Institute Hospital 12 de Octubre
2022-2023
Centro de Investigación en Red en Enfermedades Cardiovasculares
2017-2022
Centro de Investigación Biomédica en Red
2017-2022
Madrid Health Service
2022
Hospital Clínico Universitario de Valladolid
2018-2021
Introduction: Coronavirus disease 2019 (COVID-19) is a systemic characterized by disproportionate inflammatory response in the acute phase. This study sought to identify clinical sequelae and their potential mechanism. Methods: We conducted prospective single-center (NCT04689490) of previously hospitalized COVID-19 patients with without dyspnea during mid-term follow-up. An outpatient group was also evaluated. They underwent serial testing cardiopulmonary exercise test (CPET), transthoracic...
Objective: To compare the incidence of selected spontaneously reported adverse events (AEs) in patients with osteoarthritis (OA) treated rofecoxib (VIOXX, 12.5 mg qd) or Arthrotec (diclofenac 50 mg/misoprostol 200 mcg bid). Methods: Double-blind, parallel-group, 6-week study aged ≥ 40 years a clinical diagnosis OA Arthrotec. Primary endpoint: self-reported diarrhea; secondary endpoints: abdominal pain, discontinuations due to AEs, GI AEs and NSAID-type (ie., acid reflux, dyspepsia,...
Advanced age, frailty, and age-related comorbidities are the major causes of pulmonary endarterectomy disqualification in patients with chronic thromboembolic hypertension (CTEPH). Balloon angioplasty (BPA) is an attractive less invasive therapy for elderly patients. However, information about safety, procedure tolerance, effectiveness BPA limited. We aimed to analyze efficacy CTEPH aged ≥70 years. This observational, descriptive, retrospective series included consecutive years, who...
Objective This study assessed the long-term effects of triple therapy with prostanoids on patients pulmonary arterial hypertension associated congenital heart disease (PAH-CHD), as there is limited information safety and efficacy this treatment approach. Methods A retrospective cohort was conducted PAH-CHD who were actively followed up at our centre. All already receiving dual combination maximum doses. Clinical characteristics, including functional class (FC), 6-minute walking test distance...
The coronavirus 2019 disease (COVID-19) pandemic threatened the Spanish health-care system. Patients with demanding conditions such as precapillary pulmonary hypertension (PH) faced a potentially severe infection, while their usual access to medical care was restricted. This prospective, unicentric study assessed impact of COVID-19 on PH patients' outcomes and operational changes in network. Sixty-three patients (41 arterial [PAH]; 22 chronic thromboembolic [CTEPH]) experienced COVID-19....
STRUCTURED ABSTRACT Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the sole causative agent of infectious disease-19 (COVID-19). Methods We performed a retrospective single-center study consecutively admitted patients between March 1 st and May 15 th, 2020, with definitive diagnosis SARS-CoV-2 infection. The primary end-point was to evaluate association lipid markers 30-days all-cause mortality in COVID-19. Results A total 654 were enrolled, an estimated 30-day...
(1) Background: Pulmonary endarterectomy (PEA) is the "gold standard" treatment for operable patients with chronic thromboembolic pulmonary hypertension (CTEPH). Persistent (PH) after PEA confers a worse prognosis. Balloon angioplasty (BPA) could represent useful therapy in this setting, but evidence about its effectiveness and safety previous limited. (2) Methods: A total of 14 persistent PH were treated BPA single center. Hemodynamic clinical effects complications procedure retrospectively...
Introduction and objectives: Complete revascularization is recommended for the management of ST-segment elevation myocardial infarctions (STEMI). Although physiological evaluation assessment nonculprit lesions, in this context, use fractional flow reserve (FFR) limited. The quantitative ratio (QFR) a new angiography-based tool functional severity. We evaluated changes occurring lesions after acute phase QFR/FFR correlation non-infarct-related arteries.
Patients with pulmonary hypertension (PH) may present hypoxaemia at rest or during daily activities. There is no epidemiological data on the prescription of long-term oxygen therapy (LTOT) in patients PH. The study sought to analyse prevalence and incidence LTOT among arterial (PAH) chronic thromboembolic (CTEPH) Spain determine predictors for this prescription.
Introduction: Coronavirus disease 2019 (COVID-19) is a systemic characterized by disproportionate inflammatory response in the acute phase. However, long-term clinical, functional, and metabolic consequences are still unknown. This study sought to identify clinical sequelae its potential intrinsic mechanism among COVID-19 survivors follow-up. Methods: We conducted prospective single-center (NCT04689490) of previously hospitalized patients with without dyspnea during mid-term follow-up,...
Abstract Introduction Coronavirus disease 2019 (COVID-19) is a highly pathogenic coronavirus characterized by systemic inflammatory response with endothelial damage and dysregulated coagulation system. Despite most patients survive the acute setting of COVID-19, their long-term clinical sequelae are unclear. We have sought to identify impact post-COVID-19 syndrome on mid-term follow-up gain some additional insights about potential explanation for persistence dyspnea. Methods This 3-month...
Abstract Introduction Pulmonary arterial hypertension (PAH) is occasionally related to previous use of drugs or toxins. The toxic oil syndrome (TOS) a model drug-induced PAH caused by the prior denatured rapeseed oil. This rare condition an acute epidemic disease in Spain, including development pulmonary hypertension, with mortality rate 82% from 1981 1987. Several cases have been discovered successive years until 2018. clinical profile and outcome those patients PAH-TOS diagnosed since 1988...
Abstract Functional impairment is largely reported after symptomatic pulmonary embolism (PE). Chronic thromboembolic disease (CTED) refers to the presence of chronic thrombotic vascular occlusion in absence hypertension (PH) at rest but with incipient vasculopathy responsible for exercise limitation. Exercise haemodynamic studies have emerged detect an abnormal response suggesting established or left ventricular filling pressure. We hypothesized that intolerance due during might be unmasked...