A5002309918- Parasitic Infections and Diagnostics
- Immunotherapy and Immune Responses
- Fungal Infections and Studies
- Toxoplasma gondii Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Parasites and Host Interactions
- Chemokine receptors and signaling
- Amoebic Infections and Treatments
- Immune Cell Function and Interaction
- Complementary and Alternative Medicine Studies
- Antifungal resistance and susceptibility
- Mosquito-borne diseases and control
- T-cell and B-cell Immunology
- Parasitic infections in humans and animals
- Parasitic Diseases Research and Treatment
- Immune cells in cancer
- Vibrio bacteria research studies
- Pediatric health and respiratory diseases
- Research on Leishmaniasis Studies
- Plant tissue culture and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Nutrition, Genetics, and Disease
- Nail Diseases and Treatments
- Inflammatory mediators and NSAID effects
- Glycosylation and Glycoproteins Research
Universidade Paulista
2016-2025
Cornell University
2024
Weill Cornell Medicine
2024
IGM Biosciences (United States)
2023
University of the Andes
2019
Universidade Federal de São Paulo
2008-2017
Peruvian University of Applied Sciences
2017
Kingston General Hospital
2016
Queen's University
2016
University of Chile
2008
Background. Although Lactobacillus casei Shirota (LcS) can benefit the immune status, effects of LcS in immune/inflammatory responses marathon runners has never been evaluated. Therefore, here we evaluated effect daily ingestion fermented milk containing or not systemic and upper airway before after a marathon. Methods. Forty-two male ingested 40 billion LcS/day (LcS group, n = 20) placebo (unfermented milk, 22) during 30 days pre-marathon. Immune/inflammatory parameters nasal mucosa serum,...
Abstract Host immunity affects tumor metastasis but the corresponding cellular and molecular mechanisms are not entirely clear. Here, we show that a subset of B lymphocytes (termed B-1 population), other lymphocytes, has prometastatic effects on melanoma cells in vivo through direct heterotypic cell-cell interaction. In classic B16 mouse model, one mechanism underlying this phenomenon is specific up-regulation subsequent homophilic interaction mediated by cell surface glycoprotein MUC18...
ABSTRACT Treatment with gamma-aminobutiric acid (GABA(B)) receptor agonist, +/-baclofen, has been shown to reduce ethanol intake in selectively bred Sardinian alcohol-preferring rats. The general goal of the present study was characterize high consumption high-alcohol-drinking University Chile bibulous (UChB) rats regard anti-alcohol effect GABA(B) stimulation. UChB were treated more active enantiomer baclofen [R(+)-baclofen; at a dose 1.0, 2.0 or 3.0 mg/kg] administered intraperitoneally...
In previous results mice treated with high dilutions of antimony presented reduction monocyte migration to the site infection increase in B lymphocytes population local lymph node.To know mechanisms involved, a series vitro studies was done, using co-cultures macrophages (RAW 264.7) and Leishmania (L.) amazonensis different (Antimonium crudum or AC), times.Spreading, phagocytosis, oxidative activity macrophages, viability free promastigotes cytokines/chemokines concentration supernatant were...
Increasing evidence indicates that tumors require a constant influx of myelomonocytic cells to support their malignant behavior. This is caused by tumor-derived factors, which recruit and induce functional differentiation cells, most are macrophages. Although myeloid lineages the classical precursors macrophages, B-lymphoid such as B-1 subset B-lymphocytes found predominantly in pleural peritoneal cavities, also able migrate inflammatory sites differentiate into mononuclear phagocytes...
B-1 cells constitute a distinct B cell population with unique phenotypic and functional characteristics. They represent the main found in mouse peritoneal pleural cavities. The communication between macrophages has been previously studied, effect this interaction on described. Using an vitro co-culture model, herein we demonstrated that were able to increase survival rates stimulate proliferation of cells. IL-6 was also be important survival; recombinant increases percentage viable culture....
Microsporidia are recognized as opportunistic pathogens in individuals with immunodeficiencies, especially related to T cells. Although the activity of CD8+ lymphocytes is essential eliminate these pathogens, earlier studies have shown significant participation macrophages at beginning infection. Macrophages and other innate immunity cells play a critical role activating acquired immunity. After programmed cell death, fragments or apoptotic bodies cleared by phagocytic cells, phenomenon...
Microsporidiosis are diseases caused by opportunistic intracellular fungi in immunosuppressed individuals, as well transplanted patients, the elderly and children, among others. Diabetes mellitus (DM) is a metabolic disease characterized hyperglycemia decreased T cell response, neutrophil function, humoral immunity failure, increasing susceptibility to infections. Here, we investigated of streptozotocin (STZ)-induced type I diabetic and/or mice encephalitozoonosis Encephalitozoon cuniculi....
Here, we have investigated the possible effect of B-1 cells on activity peritoneal macrophages in E. cuniculi infection. In presence cells, had an M1 profile with showed increased phagocytic capacity and index, associated intense microbicidal a higher percentage apoptotic death. The absence was predominance M2 macrophages, reduced index activity, pro-inflammatory anti-inflammatory cytokines production, percentual necrosis addition, spore polar tubular extrusion observed, which is important...
Although it has been previously demonstrated that acute inflammation can promote the tumor growth of a sub-tumorigenic dose melanoma cells through 5-lipoxygenase inflammatory pathway and its product leukotriene B4, also peritumoral treatment with eicosapentaenoic acid product, B5, reduces development, effect by gavage omega-3 omega-6 in microenvironment favorable to associated never studied. C57BL/6 mice were coinjected 1 × 106 apoptotic plus 103 viable into subcutaneous tissue treated...
B-1 cells can be differentiated from B-2 because they are predominantly located in the peritoneal and pleural cavities have distinct phenotypic patterns activation properties. The role of both cell populations cancer progression is still controversial. Previous studies indicated that direct contact between B16 melanoma tumor (B16) increases metastatic potential cells. However, cellular changes induced during interaction these two types not been evaluated. In present study, it hypothesized...
B-1 lymphocytes are known to increase the metastatic potential of B16F10 melanoma cells via extracellular signal-regulated kinase (ERK) pathway. Since IL-10 is associated with performance, we hypothesized that could be implicated in progression melanoma. In present work, found C57BL/6 mice, inoculated were co-cultivated from knockout developed fewer nodules than ones which injected cultivated presence wild-type cells. The impairment was correlated low activation ERK signaling pathway,...
Depending on Leishmania species and the presence/absence of virulence factors, extracellular vesicles (EVs) can differently stimulate host immune cells. This work is aimed at characterizing evaluating protective role EVs released by amazonensis promastigotes under different maintenance conditions. Initially, using a control strain, we standardized 26°C as best release temperature to obtain with potential in experimental leishmaniasis model. Then, long-term (LT-P) L. were obtained after vitro...
Three Xanthomonas strains were isolated from natural environments in Venezuela and studied morphologically, subjected to biochemical characterization microbiologically molecularly identified. In order reconfirm the identity of these strains, production xanthan was induced for campestris vesicatoria isolates, obtaining a yield 7 35mg/100mL culture, respectively; by FTIR spectroscopy obtained products confirmed formation during growth strains. Characterized submitted resistance studies 14...
Microsporidia, including Encephalitozoon intestinalis, are emerging pathogens which cause opportunistic infections in immunocompromised patients, such as those with AIDS, cancer, the elderly and people on immunosuppressive drugs. Intestinal mucosa (IM) is crucial for developing an efficient adaptive immune response against pathogenic micro-organisms, thereby preventing their colonization subsequent infection. As drugs affect intestinal little known. In present study, we investigated to E....