A5028282908- Bone Tissue Engineering Materials
- NF-κB Signaling Pathways
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Parasitic Infections and Diagnostics
- Cell death mechanisms and regulation
- Immunotherapy and Immune Responses
- Genomics, phytochemicals, and oxidative stress
- Herpesvirus Infections and Treatments
- Multiple Myeloma Research and Treatments
- Cytokine Signaling Pathways and Interactions
- PI3K/AKT/mTOR signaling in cancer
- Vector-borne infectious diseases
- Fungal Infections and Studies
- Melanoma and MAPK Pathways
- Medication Adherence and Compliance
- Cell Adhesion Molecules Research
- Chemokine receptors and signaling
- Diabetes and associated disorders
- Toxin Mechanisms and Immunotoxins
- Metal complexes synthesis and properties
- Animal Genetics and Reproduction
- Immune cells in cancer
- Vector-Borne Animal Diseases
- Cancer Mechanisms and Therapy
Universidade Federal de São Paulo
2004-2024
Instituto de Ciências Farmacêuticas
2024
Instituto de Ciências Ambientais, Químicas e Farmacêuticas
2019
Technological University of Pereira
2015
Universidade Estadual do Oeste do Paraná
2012
University of Bern
1997-2001
St Vincent's Hospital
1999
Washington State University
1997
Abstract Background Systemic therapy for cancer metastatic lesions is difficult and generally renders a poor clinical response. Structural analogs of cisplatin, the most widely used synthetic metal complexes, show toxic side-effects tumor cell resistance. Recently, palladium complexes with increased stability are being investigated to circumvent these limitations, biphosphinic cyclopalladated complex {Pd 2 [ S (-) C , N-dmpa] (μ-dppe)Cl } named C7a efficiently controls subcutaneous...
Parasites have evolved a plethora of strategies to ensure their survival. The intracellular parasite Theileria parva secures its propagation and spreads through the infected animal by infecting transforming T cells, inducing continuous proliferation rendering them metastatic. In previous work, we shown that induces constitutive activation transcription factor NF-κB, degradation cytoplasmic inhibitors. biological significance NF-κB in T. -infected however, has not yet been defined. Cells...
Infection of cattle with the protozoan Theileria parva results in uncontrolled T lymphocyte proliferation resulting lesions resembling multicentric lymphoma. Parasitized cells exhibit autocrine growth characterized by persistent translocation transcriptional regulatory factor nuclear κB (NFκB) to nucleus and consequent enhanced expression interleukin 2 receptor. How T. induces NFκB activation, required for cell activation proliferation, is unknown. We hypothesized that parasite degradation...
Holmium-containing bioactive glasses can be applied in bone cancer treatment because the holmium content neutron activated, having suitable properties for brachytherapy applications, while glass matrix regenerate alterations induced by tumor. To facilitate application of these clinical practice, we proposed a composite based on Poloxamer 407 thermoresponsive hydrogel, with applications as injectable systems. Therefore, this work, evaluated influence holmium-containing particles hydrogel (20...
Type 2 diabetes mellitus (T2DM) stands as a prevalent global public health issue caused by deficiencies in the action of insulin and/or production. In liver, plays an important role inhibiting hepatic glucose production and stimulating glycogen storage, thereby contributing to blood regulation. Kaempferitrin (KP) kaempferol (KM), flavonoids found Bauhinia forficata, exhibit insulin-mimetic properties, showing promise managing T2DM. this study, we aimed assess potential these compounds...
Caprine arthritis encephalitis virus (CAEV) is a lentivirus of goats that leads to chronic mononuclear infiltration various tissues, in particular, the radiocarpal joints. Cells monocyte/macrophage lineage are major host cells CAEV vivo. We have shown infection cultured goat macrophages with results an alteration cytokine expression vitro. Constitutive interleukin 8 (IL-8) and monocyte chemoattractant protein 1 (MCP-1) was increased infected macrophages, whereas transforming growth factor...
Abstract Two murine melanoma cell lines, Tm1 and Tm5, were derived from a nontumorigenic lineage of pigmented melanocytes, melan‐a. Both Tm5 are invariably tumorigenic in syngeneic mice when inoculated s.c. doses higher than 10 4 cells; 3 or fewer cells rarely give rise to tumors. We demonstrate that subtumorigenic inocula (10 ) as well known line (B16F10) develop vigorously growing tumor grafts only coinoculated with apoptotic, but not necrotic cells. The presence apoptotic correlates...
Fungal infections are often difficult to treat due the inherent similarities between fungal and animal cells resulting host toxicity from many antifungal compounds. Cryptococcus neoformans is an opportunistic pathogen of humans that causes life-threatening disease, primarily in immunocompromised patients. Since therapy for this microorganism limited, investigators have explored novel drug targets aim at virulence factors, such as ability grow mammalian physiological temperature (37 °C). To...
Abstract Cryptococcosis is a fungal disease caused by C . neoformans To adapt and survive in diverse ecological niches, including the animal host, this opportunistic pathogen relies on its ability to uptake nutrients, such as carbon, nitrogen, iron, phosphate, sulfur, amino acids. Genetic circuits play role response environmental changes, modulating gene expression adjusting microbial metabolism nutrients available for best energy usage survival. We studied sulfur acid biosynthesis...
Nuclear factor-κB regulates genes that control immune and inflammatory responses are involved in the pathogenesis of several diseases, including AIDS cancer. It has been proposed reactive oxygen intermediates participate NF-κB activation pathways, compounds with putative antioxidant activity such as N-acetyl-L-cysteine (NAC) pyrrolidine dithiocarbamate (PDTC) have used interchangeably to demonstrate this point. We examined their effects, separately combined, on different stages pathway,...
Increasing evidence indicates that tumors require a constant influx of myelomonocytic cells to support their malignant behavior. This is caused by tumor-derived factors, which recruit and induce functional differentiation cells, most are macrophages. Although myeloid lineages the classical precursors macrophages, B-lymphoid such as B-1 subset B-lymphocytes found predominantly in pleural peritoneal cavities, also able migrate inflammatory sites differentiate into mononuclear phagocytes...
Abstract The serine-threonine kinase AKT/PKB is a critical regulator of various essential cellular processes, and dysregulation AKT has been implicated in many diseases, including cancer. Despite action known to function mainly the cytoplasm, reported translocate nucleus. However, very little about mechanism required for nuclear import as well its this compartment. In present study, we characterized presence endogenous human melanoma cells addressed possible role by exploring potential...
Melanoma, the most aggressive form of skin cancer, poses a substantial global health threat with increasing incidence rates. Although novel targeted therapies have improved melanoma treatment, challenges persist due to poor response rates and drug resistance. Plant‐derived compounds been crucial in anticancer discovery, many natural products demonstrating ability target molecular pathways involved tumor development. In this study, anti‐melanoma potential essential oil extracted from aerial...
Anaplastic thyroid cancer (ATC) is an aggressive form of (TC), accounting for 50% total TC-related deaths. Although therapeutic approaches against TC have improved in recent years, the survival rate remains low, and severe adverse effects are commonly reported. However, unexplored alternatives based on natural compounds, such as lysicamine, alkaloid found plants with established cytotoxicity breast liver cancers, offer promise. Therefore, this study aimed to explore antineoplastic lysicamine...
Multiple myeloma (MM) is an incurable disease; a better understanding of the molecular aspects this hematological malignancy could contribute to development new treatment strategies and help improve survival rates patients with MM. Previously, methylation status deleted in colorectal cancer (DCC) gene was correlated rate MM, thus main goal study understand DCC contribution MM tumorigenesis, assess impact inhibition response bortezomib. Our results demonstrated that hypermethylation promoter...
Transforming growth factor beta (TGF-β) has been implicated in the pathogenesis of several diseases including infection with intracellular pathogens such as Mycobacterium avium complex. Infection macrophages M. induces TGF-β production and neutralization this cytokine associated decreased bacterial growth. We have previously demonstrated that epithelioid cell surrogates (ECs) derived from primary murine peritoneal through a process differentiation induced by IL-4 overlap features cells found...