A5011116882- Nanoparticle-Based Drug Delivery
- Cancer Treatment and Pharmacology
- Advanced Drug Delivery Systems
- Bladder and Urothelial Cancer Treatments
- Crystallization and Solubility Studies
- Drug Transport and Resistance Mechanisms
- Erythrocyte Function and Pathophysiology
- Advanced Polymer Synthesis and Characterization
- Surfactants and Colloidal Systems
- Bone Tissue Engineering Materials
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Microfluidic and Capillary Electrophoresis Applications
- Dendrimers and Hyperbranched Polymers
- Angiogenesis and VEGF in Cancer
- Polymer Surface Interaction Studies
- 3D Printing in Biomedical Research
- Orthopedic Infections and Treatments
- Hemoglobin structure and function
- Urinary Bladder and Prostate Research
- Cell death mechanisms and regulation
- Peptidase Inhibition and Analysis
- Protein Kinase Regulation and GTPase Signaling
- Neonatal Health and Biochemistry
University of British Columbia
2011-2023
University of British Columbia Hospital
2011-2021
Southmead Hospital
2020
North Bristol NHS Trust
2020
Morriston Hospital
2019
Great Western Hospital
2016
Centre for Drug Research and Development
2010-2011
BC Cancer Agency
2009
Vancouver General Hospital
2008
University of Georgia
2008
Abstract: The objective of this work was to investigate the use nanocrystalline cellulose (NCC) as a drug delivery excipient. NCC crystallites, prepared by an acid hydrolysis method, were shown have nanoscopic dimensions and exhibit high degree crystallinity. These crystallites bound significant quantities water soluble, ionizable drugs tetratcycline doxorubicin, which released rapidly over 1-day period. Cetyl trimethylammonium bromide (CTAB) surface increased zeta potential in...
We report the development of a magnetically controlled MEMS device capable on-demand release defined quantities an antiproliferative drug, docetaxel (DTX). Controlled DTX with dosage suitable for treatment diabetic retinopathy has been achieved 35 days. The consists drug-loaded microreservoir (∅6 mm × ∼550 μm), sealed by elastic magnetic PDMS (polydimethylsiloxane) membrane 40 μm) laser-drilled aperture (∼100 100 μm2). By applying field, deforms, causing discharge drug solution from device....
This paper discusses the binding and release properties of hydrophobically modified hyperbranched polyglycerol-polyethylene glycol copolymers that were originally developed as human serum albumin (HSA) substitutes. Their unimolecular micellar nature in aqueous solution has been proven by size measurements other spectroscopic methods. These polymers aggregate weakly solution, but aggregates are broken down low shear forces or encapsulating a hydrophobic ligand within polymer. The small...
We report the development of a magnetically controlled drug delivery device for on-demand release to treat chronic diseases. The devices consist drug-loaded micro-reservoirs (6 mm in diameter and ∼550 μm depth), sealed by magnetic PDMS (polydimethylsiloxane) membranes (∅ 6 × 40 μm) with laser-drilled apertures actuated an external field. present detailed analysis actuation forces provide estimate resulting membrane deflections. reservoirs are fabricated molding loaded drugs using solvent...
The purpose of this study was to evaluate the diblock copolymer poly(DL-lactide)-block-methoxy polyethylene glycol as an i.v. delivery vehicle for paclitaxel. Nude mice were implanted s.c. with fragments MV-522 lung carcinomas and treated paclitaxel on a daily x 5 schedule when tumors approximately 5x5 mm in size. Cremophor or polymeric micellar given i.p. at maximum tolerated dose (Cremophor MTD: 20 mg/kg/day i.p.; 25 100 i.p.). measured using callipers during experiment accurately weighted...