A5076040142- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Malaria Research and Control
- Mosquito-borne diseases and control
- Biosensors and Analytical Detection
- SARS-CoV-2 detection and testing
- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
- Viral Infections and Outbreaks Research
- HIV/AIDS drug development and treatment
- Respiratory viral infections research
- Advanced biosensing and bioanalysis techniques
Kenya Medical Research Institute
2022-2025
University of Nairobi
2019
Antimalarial drug resistance is a substantial impediment to malaria control. The spread of has been described using genetic markers which are important epidemiological tools. We carried out temporal analysis changes in allele frequencies 12 over two decades changing antimalarial policy Kenya. did not detect any the validated kelch 13 (k13) artemisinin markers, nonetheless, single k13 allele, K189T, was maintained at stable high frequency (>10%) time. There distinct shift from chloroquine...
Abstract We undertook a point-of-care test for hepatitis B core-related antigen in adults with virus Kilifi, Kenya. A positive identified all individuals viral load >200 000 IU/mL and who were e positive. It also correlated higher alanine aminotransferase (ALT) level (P = .03), raised aspartate transaminase-to-platelet ratio index (APRI) < .001), elastography scores .03).
Coronavirus Disease-2019 tests require a Nasopharyngeal (NP) and/or Oropharyngeal (OP) specimen from the upper airway, which virus RNA is extracted and detected through quantitative reverse transcription-Polymerase Chain Reaction (qRT-PCR). The viability of maintained after collection by storing NP/OP swabs in Viral Transport Media (VTM). We evaluated performance four transport media: locally manufactured ("REVITAL") (RVTM), Standard Universal (SUTM), PBS 0.9% (w/v) NaCl (normal saline)....
Objectives Chronic hepatitis B infection affects 65 million people in the WHO African Region, but only 4.2% of these are diagnosed and 0.2% on treatment. Here, we present a short report describing establishment virus (HBV) programme Kenya. We share experiences, successes challenges to support development future programmes. Methods From March 2023, began ‘STRIKE-HBV’ Study identify living with HBV (PLWHB) Kilifi, employed local staff provided education training. Individuals were identified...
There is a growing concern for malaria control in the Horn of Africa region due to spread and rise frequency Plasmodium falciparum Histidine-rich Protein (hrp) 2 3 deletions. Parasites containing these gene deletions escape detection by major PfHRP2-based rapid diagnostic test. In this study, presence Pfhrp2/3 was examined uncomplicated patients Kilifi County, from moderate-high transmission. 345 samples were collected Pingilikani dispensary 2019/2020 during routine care attending primary...
We undertook a point of care test (POCT) for hepatitis B core related antigen (HBcrAg) on adults living with HBV in Kilifi, Kenya. A positive identified all those VL >200,000 IU/ml, who were HBeAg positive, and correlated well abnormal ALT, APRI elastography scores.
Abstract Coronavirus Disease-2019 tests require a Nasopharyngeal (NP) and/or Oropharyngeal (OP) specimen from the upper airway, which virus RNA is extracted and detected through quantitative reverse transcription-Polymerase Chain Reaction (qRT-PCR). The viability of maintained after collection by storing NP/OP swabs in Viral Transport Media (VTM). We evaluated performance four transport media: locally manufactured (“REVITAL”) (RVTM), Standard Universal (SUTM), PBS 0.9% (w/v) NaCl (normal...