A5024429402- Antifungal resistance and susceptibility
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Oral microbiology and periodontitis research
- Lipoproteins and Cardiovascular Health
- Thyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Bariatric Surgery and Outcomes
- HIV/AIDS oral health manifestations
- Fungal Infections and Studies
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Parathyroid Disorders and Treatments
- Electrolyte and hormonal disorders
- Cancer, Hypoxia, and Metabolism
- Nail Diseases and Treatments
- Diabetes and associated disorders
- Neuroblastoma Research and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Ion Transport and Channel Regulation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
National Hospital of Sri Lanka
2016-2024
Colombo North Teaching Hospital
2014-2024
Pondicherry Institute of Medical Sciences
2016
Hayatabad Medical Complex
2016
Post Graduate Medical Institute
2016
Motilal Nehru Medical College
2016
Bharti Hospital
2016
Chellaram Hospital
2016
Teaching Hospital Kandy
2016
Institute of Post Graduate Medical Education and Research
2016
Diagnosing Cushing syndrome can be challenging due to common symptoms in the general population, leading a complex process. Here we present case of disease middle aged man with delayed diagnosis following femoral neck fracture, context obesity, poorly controlled diabetes, hypertension and history tuberculosis. The patient was successfully treated positive outcome.
Introduction: Approximately, 33% patients with diabetes are afflicted onychomycosis. In the past, nondermatophyte molds have been regarded as opportunistic pathogens; recently, Aspergillus species considered emerging pathogens of toenail infections. Sri Lanka, prevalence in onychomycosis among diabetics is not well documented. Objective: To determine proportion onychomycosis, risk factors and knowledge diabetics. Materials Methods: This was descriptive cross-sectional study. Three hundred...
Background: Superficial fungal foot infection (SFFI) in diabetic patients increases the risk of developing syndrome. Sixteen percent urban population is suffering from diabetes Sri Lanka. As are more prone to get infections, early intervention advisable owing progressive nature infection. There no data on prevalence SFFIs Objective: To determine etiological agents causing SFFI with type 2 diabetes. Materials and Methods: Three hundred eighty five were included. Nail clippings swabs collected...
Aims: Oral candidiasis is a major oral manifestation of uncontrolled diabetes mellitus, and number cofactors are associated with the pathogenesis this infection. Here, we describe prevalence Candida in Sri Lankan cohort type 2 mellitus risk factors that predispose them to common fungal Methods: A case-control study was conducted 250 diabetics 81 nondiabetic controls. Clinical demographic data were collected using an interviewer administered questionnaire, patient records. rinse samples...
<h3>Objective:</h3> To determine an appropriate age threshold at which to prescribe aspirin for primary cardiovascular disease (CVD) prevention among men and women without diabetes. <h3>Design:</h3> Cross-sectional study. <h3>Setting:</h3> 304 general practices in England Wales contributing The Health Improvement Network (THIN) electronic patient files. <h3>Participants:</h3> Subjects aged between 30 75 years diabetes, not prescribed any lipid-lowering treatment with no previous history of...
Dengue fever (DF) is one of the world's emerging infectious diseases. The steady increase in European tourists, as well soldiers serving on peacekeeping duties, endemic areas, coupled with present resurgence dengue, raises risk exposure for a large number travellers. Significant numbers travellers have, fact, developed DF. There dengue haemorrhagic (DHF) who revisit same place, and they have potential not only to acquire, but also spread, viral infection. Of concern outbreak previously...
Gitelman syndrome (GS) is a rare autosomal recessively inherited salt-wasting tubulopathy associated with mutations in the SLC12A3 gene, which encodes for NaCl cotransporter (NCC) kidney. In this report, we describe two siblings from Sri Lankan non-consanguineous family presenting hypokalaemia renal potassium wasting, hypomagnesemia, hypocalciuria and hypereninemic hyperaldosteronism normal blood pressure. Genetic testing showed that both were homozygotes novel missense mutation exon 10 of...
Oral candidiasis is being frequently recognized in patients with diabetes, and associated multiple pathogens including Candida albicans, parapsilosis, glabrata tropicalis. The aim of this study was to evaluate a usefulness Multiplex Polymerase Chain Reaction as rapid diagnostic tool for identification four oral diabetes.A multiplex PCR optimized identify species concentrated rinse samples. Common reverse primer, ITS4 species-specific forward primers targeting ITS1 ITS2 regions yeast genome...
Introduction: Olfactory Neuroblastoma (ONB) is a rare malignant Neuroendocrine tumour. It rarely reported to cause Ectopic Cushing’s Syndrome (ECS). Here, we report case of ECS secondary ONB.Case Description: A 40-year-old lady presented with right sided focal seizures complicated status epilepticus. She was diagnosed Diabetes Mellitus severe hyperglycaemia three weeks prior this admission and started on insulin therapy. Investigations revealed hypokalaemia. MRI brain showed no lesions but...
Strategies for initiating statin use among adult patients with diabetes primary cardiovascular disease (CVD) prevention include treating all (assuming is a coronary risk equivalent) or who are at of developing CVD. The aim the study was to combine both strategies derive an appropriate age cutoff prescribing statins. By considering different strategies, we also assess effectiveness and efficiency reduce CVD events.This cross-sectional care population using electronic patient files from 304...
Official Journal of the Endocrine Society Sri Lanka. The Lanka Diabetes Endocrinology and Metabolism (SJDEM) publishes original research articles, reviews, other special features related to diabetes, endocrinology metabolism in humans human tissue.
Subacute thyroiditis is an inflammatory thyroid disorder. It often triggered following viral infections. Amid the current COVID-19 pandemic, several cases of subacute were reported worldwide related to SARS-CoV-2 infection and vaccines. We report a rare case possibly immunization with inactivated vaccine Sinopharm BIBP. A 29-year-old previously healthy Sri Lankan woman presented anterior neck pain, low-grade fever fatigue appearing 7 days after second dose She apparently similar symptoms...
Candida dubliniensis shares a wide range of phenotypic characteristics with albicans including common trait called germ tube positivity. Hence, laboratory differentiation these two species is cumbersome. Duplex PCR analyses for C. and was performed directly on DNA extracted from total 122 positive isolates derived 100 concentrated oral rinse samples random cohort diabetics attending clinic in Sri Lanka. These results were confirmed by sequencing internal transcribed spacer (ITS) region rDNA...
Primary hyperaldosteronism is a known cause for secondary hypertension. In addition to its effect on blood pressure, aldosterone exhibits proinflammatory actions and plays role in immunomodulation/development of autoimmunity. Recent researches also suggest significant thyroid dysfunction among patients with hyperaldosteronism, but exact causal relationship not established. Autoimmune hyperthyroidism (Graves' disease) primary rarely coexist underlying mechanisms associating the two are still...
PREAMBLE Health issues in general, and endocrine related particular, are vital determinants of the prosperity society. The people South Asia share many common features face similar challenges to health. These hurdles have been amplified by rapid socioeconomic lifestyle changes taking place region. Competing priorities limited resources prevented implementation strategies meet these obstacles. SAFES wishes improve health care delivery Asia, using a broad-based, inclusive strategy, based on...
The objectives of the study were to determine whether identifying patients with metabolic syndrome (MetS) (as defined by International Diabetes Federation [IDF] criteria) among diabetes would affect decision prescribe statin for primary prevention cardiovascular disease (CVD), based on currently available public health guidelines. We analysed most recent recorded CVD risk profiles obtained from electronic patient files 304 general practices in England and Wales. Of 60,258 diabetes, 11,005...
Myxedema crisis is a life-threatening extreme form of hypothyroidism with high mortality rate if left untreated. commonly seen in older patients, especially women, and associated signs hypothyroidism, hypothermia, hyponatraemia, hypercarbia, hypoxemia. Patients might present different organ specific symptoms. Seizures are recognized but rare manifestation myxedema very rate. Prompt diagnosis appropriate management may improve the prognosis. Many contributory factors involve development...
Obesity and its complications have become a major public health problem. Health risk conferred by obesity can be reduced sustained weight loss but this is difficult in majority. Bariatric surgery (BS) has proven to provide an excellent answer problem there minimal data South Asians especially Sri Lankans. In study we aimed find the effect of BS on improving We did retrospective analysis medical records 170 obese patients who underwent at Colombo Teaching Hospital, Lanka. Overall 74.1% were...
Despite limited evidence, non-daily dosing of statins is recommended for managing muscle symptoms associated with statin therapy. We assessed the tolerability and effectiveness every-other-day atorvastatin compared to daily in patients having A parallel-group, outcome-assessment-blinded, randomized controlled clinical trial was conducted at Colombo South Teaching Hospital, Sri Lanka. Patients pain, tenderness or cramps alone combination ≥2 weeks while on ≥1 month, no alternative cause, were...