A5043184983- Liver Disease Diagnosis and Treatment
- Lymphatic System and Diseases
- Immune cells in cancer
- Mesenchymal stem cell research
- Angiogenesis and VEGF in Cancer
- Lipid metabolism and disorders
University of Pittsburgh
2023
Peripheral ischemia caused by peripheral artery disease is associated with systemic inflammation, which may aggravate underlying comorbidities such as atherosclerosis and heart failure. However, the mechanisms of increased inflammation inflammatory cell production in patients remain poorly understood.
Insulin resistance is a compromised response to insulin in target tissues such as liver. Emerging evidence shows that vascular endothelial cells (ECs) are critical mediating glucose metabolism. However, how liver ECs can regulate inflammation the setting of still unknown. Using genome-wide transcriptome analysis isolated from diabetic mice, we found enrichment genes involved epidermal growth factor receptor (Egfr) signaling. In line with this, hepatic sinusoidal mice had elevated levels Egfr...