A5052846085- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- HIV-related health complications and treatments
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- HIV/AIDS Research and Interventions
- Inflammasome and immune disorders
- Long-Term Effects of COVID-19
- Adolescent and Pediatric Healthcare
- Lipid metabolism and disorders
- T-cell and B-cell Immunology
- Frailty in Older Adults
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- SARS-CoV-2 detection and testing
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- COVID-19 Impact on Reproduction
- Diabetes and associated disorders
Université de Montpellier
2019-2025
Institut de Génétique Humaine
2019-2025
Centre National de la Recherche Scientifique
2019-2025
Centre Hospitalier Universitaire de Nîmes
2022
Centre Hospitalier Universitaire de Montpellier
2021
Abstract Severe SARS-CoV-2 infections are characterized by lymphopenia, but the mechanisms involved still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized that infection-mediated lymphopenia could also be related to T cell apoptosis. By comparing intensive care unit (ICU) and non-ICU COVID-19 patients with age-matched healthy donors, found a strong positive correlation between plasma levels soluble FasL (sFasL) surface expression Fas/CD95 propensity cells die CD4...
As about 10% of patients with COVID-19 present sequelae, it is important to better understand the physiopathology so-called long COVID.
Persistent immune activation in virologically suppressed HIV-1 patients, which may be the consequence of various factors including microbial translocation, is a major cause comorbidities. We have previously shown that different profiles distinguished virological responders. Here, we tested hypothesis particular profile might translocation. To this aim, measured 64 soluble and cell surface markers inflammation CD4+ CD8+ T-cell, B cell, monocyte, NK endothelial 140 adults under efficient...
Chronic immune activation persists in persons living with HIV-1 even though they are aviremic under antiretroviral therapy, and fuels comorbidities. In previous studies, we have revealed that virologic responders present distinct profiles of activation, one these is related to microbial translocation. the work, tested 140 HIV-1-infected adults efficient treatment for a mean duration eight years whether low-level viremia might be another cause activation. We observed frequency between 1 20...
T cell cytotoxicity plays a major role in antiviral immunity. Anti-SARS-CoV-2 immunity may determine acute disease severity, but also the potential persistence of symptoms (long COVID). We therefore measured expression perforin, cytotoxic mediator, cells patients recently hospitalized for SARS-CoV-2 infection. recruited 54 volunteers confirmed as being SARS-CoV-2-infected by RT-PCR and admitted to Intensive Care Units (ICUs) or non-ICU, 29 age- sex-matched healthy controls (HCs). Amounts...
Abstract Genetic defects in the ability to deliver effective perforin have been reported patients with hemophagocytic lymphohistiocytosis. We tested hypothesis that a primary deficiency might also be causal severe SARS-CoV-2 infection. recruited 54 volunteers confirmed as being SARS-CoV-2–infected by RT-PCR and admitted intensive care units or non–intensive age- sex-matched healthy controls. Compared controls, percentage of perforin-expressing CD3−CD56+ NK cells quantified flow cytometry was...
Abstract Background People living with HIV (PLWH) are at risk of frailty, which is predictive for death. As an overactivity the immune system thought to fuel we characterized activation profiles linked frailty. Methods We quantified twenty-seven markers in forty-six virological responders (four females and forty-two males; median age, 74 years; duration infection, 24 undetectability, 13 years), whose frailty was determined according Fried criteria. T cell NK evaluated by flow cytometry,...
Abstract In addition to an inflammatory reaction, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-infected patients present lymphopenia, which we recently reported as being related abnormal programmed cell death. As efficient humoral response requires CD4 T-cell help, hypothesized that the propensity of T cells die may impact quantity and quality in acutely infected individuals. specific immunoglobulins (Ig)A, IgM, IgG against SARS-CoV-2 nucleocapsid (N), membrane (M), spike...
Latent infectious agents, microbial translocation, some metabolites and immune cell subpopulations, as well senescence modulate the level quality of activation our system. Here, we tested whether various in vivo profiles may be distinguished a general population. We measured 43 markers by 8-color flow cytometry ELISA 150 adults, performed double hierarchical clustering biomarkers volunteers. identified five different profiles. Profile 1 had high proportion naïve T cells. By contrast,...
Abstract We tested the hypothesis that a particular immune activation profile might be correlated with insulin resistance in general population. By measuring 43 markers of immune, endothelial, and coagulation activation, we have previously shown five different profiles may distinguished 150 volunteers. One these profiles, Profile 2, characterized by CD4+ T cell senescence, inflammation, monocyte, B cell, endothelial presented elevated insulinemia, glycemia, triglyceridemia, γ-glutamyl...
HIV infection induces a 75% increase in the risk of developing neurocognitive impairment (NCI), which has been linked to immune activation. We therefore looked for activation markers correlating with NCI. Sixty-five people aged 55-70 years living controlled HIV-1 were enrolled study and their ability was assessed according Frascati criteria. Fifty-nine T4 cell, T8 NK monocyte activation, inflammation endothelial measured peripheral blood. White matter hyperintensities (WMH) identified by...