A5103281020- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- CAR-T cell therapy research
- Head and Neck Cancer Studies
- COVID-19 diagnosis using AI
- Colorectal Cancer Treatments and Studies
- Ionosphere and magnetosphere dynamics
- Lung Cancer Diagnosis and Treatment
- Cancer survivorship and care
- Geomagnetism and Paleomagnetism Studies
- Immunotherapy and Immune Responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tropical and Extratropical Cyclones Research
- Hemoglobinopathies and Related Disorders
- Virus-based gene therapy research
- Adipose Tissue and Metabolism
- Cellular Mechanics and Interactions
- Telomeres, Telomerase, and Senescence
- Caveolin-1 and cellular processes
- Chronic Myeloid Leukemia Treatments
- Radiomics and Machine Learning in Medical Imaging
- Oral health in cancer treatment
- Colorectal and Anal Carcinomas
- Phonocardiography and Auscultation Techniques
- Adolescent and Pediatric Healthcare
University of Debrecen
1977-2025
University of Michigan
2022
Yokohama City University
2005-2010
HER2-targeted monoclonal antibodies improve the outcome for advanced breast cancer patients; however, resistance to therapy is still frequent. Epitope masking and steric hindrance antibody binding through matrix components are thought be major mechanism. We asked whether tumors resistant trastuzumab can eliminated by CAR T cells redirected same domain. While saturating doses of in presence CD16.176V.NK-92 effector derived equally well recognized killed HER2-positive tumor a monolayer, only...
Although the recently concluded CLEOPATRA trial showed clinical benefits of combining trastuzumab and pertuzumab for treating HER2-positive metastatic breast cancer, monotherapy is still mainstay in adjuvant settings. Since resistance occurs over half these cancers, we examined mechanisms by which treatment intrinsically trastuzumab-resistant -sensitive tumors can benefit from combination antibodies. F(ab')2 both were generated validated order to separately analyze antibody-dependent...
HER2 positive JIMT-1 breast tumors are resistant to trastuzumab treatment in vitro and develop resistance vivo SCID mice. We explored whether these could still be eliminated by T cells redirected a second-generation chimeric antigen receptor (CAR) containing CD28 costimulatory domain targeting with trastuzumab-derived scFv. In vitro, engineered this specific CAR recognized target as judged cytokine production cytolytic activity. vivo, the administration of twice weekly had no effect on...
Chest X-ray evaluation is challenging due to its high demand and the complexity of diagnoses. In this study, we propose an optimized deep learning model for multi-label classification chest images. We leverage pretrained convolutional neural networks (CNNs) such as VGG16, ResNet 50, DenseNet 121, modifying their output layers fine-tuning models. employ a novel optimization strategy using Hyperband algorithm efficiently search hyperparameter space while adjusting fully connected CNNs. The...
Abstract Objectives To examine factors impacting diagnostic evaluation of suspected deep vein thrombosis (DVT) by analyzing the test ordering patterns and provider decision-making within a universal health coverage system in Hungary. Methods We analyzed orders for DVT between 2007 2020, financial framework influencing practices. An anonymous survey was also conducted among Emergency Department physicians to explore decision-making. Results A total 6,821 patients were identified. From 2008...
Abstract Monoclonal antibody‐based immunotherapeutics will dominate Pharma's next generation of blockbuster drugs, and Fc‐associated functions, including antibody dependent cellular cytotoxicity (ADCC) are among the highly desired activities mediated by these antibodies. Therefore, quantitative evaluation ADCC is required during drug development. Our objective was to find most suitable reliable nonradioactive method for analysis in vitro against adherent cells, which often serve as models...
The integration of AI into healthcare is widely anticipated to revolutionize medical diagnostics, enabling earlier, more accurate disease detection and personalized care.
Anemia is a severe global public health issue. Testing practices for anemia suggest overuse of screening laboratory tests and misinterpretation studies even in "easy-to-diagnose" underlying causes, leading to late diagnoses missed treatment opportunities. We aimed develop complete efficient algorithm clinical pathologists medicine physicians the differential diagnosis anemia.
Objectives Immune checkpoint inhibitors (ICIs) stimulate antitumor immune responses and, in parallel, they might trigger autoimmune and other immunopathological mechanisms eventually leading to immune-related adverse events (irAE). In our study, we assessed patients with malignancies who underwent anti-PD-1 treatment at the University of Debrecen, Clinical Center. Patients methods Between June 2017 May 2021, 207 started ICI university. A total 157 received nivolumab 50 were treated...
Key words juvenile idiopathic arthritis (JIA) - inflammatory bowel disease (IBD) Crohn’s (CD) biologicals TNFα
Chest X-rays are vital in healthcare for diagnosing various conditions due to their low Radiation exposure, widespread availability, and rapid interpretation. However, interpretation requires specialized expertise, which can limit scalability delay diagnoses. This study addresses the multi-label classification challenge of chest X-ray images using X-ray14 dataset. We propose a novel online ensemble technique that differs from previous penalty-based methods by focusing on combining individual...
Meeting abstracts Trastuzumab (Herceptin®), a humanized anti-ErbB2 antibody is specific targeted therapy against ErbB2 positive tumors, with history of both success and high rate resistance. Another antibody, pertuzumab (Perjeta®) inhibits heterodimerization.
Abstract Although the recently concluded CLEOPATRA trial showed clinical benefits of combining trastuzumab and pertuzumab for treating HER2-positive metastatic breast cancer, monotherapy is still mainstay in adjuvant settings. Since resistance occurs over half these cancers, we examined mechanisms by which treatment intrinsically trastuzumab-resistant -sensitive tumors can benefit from combination antibodies. F(ab')2 both were generated validated order to separately analyze...
Magnetic switchbacks are rapid high amplitude reversals of the radialmagnetic field in solar wind that do not involve a heliosphericcurrent sheet crossing. First seen sporadically seventies inMariner and Helios data, were later observed by theUlysses spacecraft beyond 1 au have been recently identified as atypical component fluctuations inner heliosphereby Parker Solar Probe spacecraft. We provide simple yetpredictive theory for formation these magnetic reversals: theswitchbacks produced...