A5069692025- Immunotherapy and Immune Responses
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- TGF-β signaling in diseases
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Transgenic Plants and Applications
- Cell Adhesion Molecules Research
- Acute Myeloid Leukemia Research
- T-cell and B-cell Immunology
- Influenza Virus Research Studies
- Herpesvirus Infections and Treatments
- Osteoarthritis Treatment and Mechanisms
- Viral Infections and Outbreaks Research
- Immune Response and Inflammation
- Bone Metabolism and Diseases
- Pneumonia and Respiratory Infections
- Collagen: Extraction and Characterization
- HER2/EGFR in Cancer Research
- Retinoids in leukemia and cellular processes
- Animal Virus Infections Studies
- Erythrocyte Function and Pathophysiology
- Tendon Structure and Treatment
Novavax (United States)
2017-2021
Iomai (United States)
2004-2019
University of Michigan
1992
Care Resource
1988-1991
Thoratec Corporation (United States)
1989-1990
Collagen Medical (United States)
1986-1990
Oklahoma Medical Research Foundation
1987-1989
National Cancer Institute
1988-1989
Palo Alto Institute
1987
University of California, San Diego
1987
Transforming growth factor α (TGF-α) is produced by and required for the of epithelial cells angiogenic in vivo. Since epidermal hyperplasia angiogenesis are hallmarks psoriasis, TGF-α gene expression was analyzed biopsies normal psoriatic skin. messenger RNA protein much more abundant lesional epidermis than normal-appearing skin patients or epidermis. In contrast, levels transforming β1 (TGF-β1), which inhibits cell growth, not significantly different normal, uninvolved, Thus, may involve...
Abstract The COVID-19 pandemic continues to spread throughout the world with an urgent need for a safe and protective vaccine effectuate herd protection control of SARS-CoV-2. Here, we report development SARS-CoV-2 subunit (NVX-CoV2373) from full-length spike (S) protein that is stable in prefusion conformation. NVX-CoV2373 S form 27.2-nm nanoparticles are thermostable bind high affinity human angiotensin-converting enzyme 2 (hACE2) receptor. In mice, low-dose saponin-based Matrix-M adjuvant...
The course of infection with the protozoan parasite Leishmania is determined in part by their early replication macrophages, exclusive host cells for these organisms. Although factors contributing to survival are not well understood, cytokines influence infection. Transforming growth factor-β (TGF-β) a multipotential cytokine diverse effects on immune system, including down-regulation certain macrophage functions. Leishmanial induced production active TGF-β, both vitro and vivo. TGF-β was...
We have localized transforming growth factor-beta (TGF-beta) in many cells and tissues with immunohistochemical methods, using two polyclonal antisera raised to different synthetic preparations of a peptide corresponding the amino-terminal 30 amino acids TGF-beta 1. These antibodies give distinct staining patterns; by anti-CC(1-30) is intracellular. This differential pattern consistently observed several systems, including cultured tumor cells; mouse embryonic, neonatal, adult tissues;...
There is an urgent need for a safe and protective vaccine to control the global spread of SARS-CoV-2 prevent COVID-19. Here, we report immunogenicity efficacy subunit (NVX-CoV2373) produced from full-length spike (S) glycoprotein stabilized in prefusion conformation. Cynomolgus macaques (Macaca fascicularis) immunized with NVX-CoV2373 saponin-based Matrix-M™ adjuvant induced anti-S antibody that was neutralizing blocked binding human angiotensin-converting enzyme 2 (hACE2) receptor....
Two apparently homologous proteins, designated CIF-A and CIF-B, were previously isolated from bovine bone on the basis of their cartilage-inducing activity in culture. has been shown to probably be identical transforming growth factor beta (TGF-beta). To address question tissue localization, antibodies produced using a synthetic polypeptide N-terminal residues 1-30. The immunoreactive with human TGF-beta, did not recognize other molecular weight species crude extracts. used...
Transforming growth factor beta 1 (TGF-beta 1) has been shown to be associated with active centers of hematopoiesis and lymphopoiesis in the developing fetus. Therefore, effects TGF-beta on mouse were studied. is a potent inhibitor IL-3-induced bone marrow proliferation, but it does not inhibit proliferation induced by granulocyte/macrophage, colony-stimulating (CSF), granulocyte CSF, erythropoietin (Epo). also inhibits multipotential colony formation cells soft agar, which includes early...
Whereas xenogeneic collagen has provided a safe and effective biomaterial for numerous medical applications, there are few instances in which data permit the correlation of immunologic profile well-defined devices with their clinical sequelae. A major exception is use injectable bovine dermal soft-tissue contour correction. The low incidence hypersensitivity been studied context efficacy safety several devices. findings indicate that such immunity usually results manifestation local symptoms...
The human immune response to bovine dermal collagen was characterized through histologic, serologic, and immunoblotting methods. Collagen-sensitive patients were identified by hypersensitivity intradermal exposure ZYDERM Collagen Implant--a pepsin-solubilized, reconstituted, collagen. Biopsies of test sites in the forearm obtained from several collagen-sensitive patients. Histologic examination revealed an implant-associated palisading foreign body granuloma. lesion also contained a mixed...
Members of the transforming growth factor beta (TGF-beta) family polypeptides were found to be potent in vitro inhibitors kappa light chain expression on normal bone marrow-derived and transformed cloned pre-B cells, maturation these cells mitogen responsiveness. The inhibition by TGF-beta was selective that Ia not blocked. Together with observations LPS, IL-1, NZB serum factors, IL-4, IFN-gamma preferentially induced either or Ia, both, a cell line, results further suggest acquisition Ig...
Since its commercial release, Zyderm collagen implant has been used to treat more than 200,000 subjects in the United States for soft-tissue contour defects and 250,000 patients internationally (including States). Approximately 3 percent of subjects' skin tested with experience localized hypersensitivity reactions collagen, whereas approximately 1 treated demonstrate symptoms at treatment sites. Of latter responses reported since conclusion clinical trials Zyderm, 56 occurred following first...
Abstract The COVID-19 pandemic continues to spread throughout the world with an urgent need for a safe and protective vaccine effectuate herd immunity control of SARS-CoV-2. Here, we report development SARS-CoV-2 subunit (NVX-CoV2373) produced from full-length spike (S) protein, stabilized in prefusion conformation. Purified NVX-CoV2373 S form 27.2nm nanoparticles that are thermostable bind high affinity human angiotensin-converting enzyme 2 (hACE2) receptor. In mice baboons, low-dose...
Transforming growth factor beta 1 (TGF-beta 1) is known to inhibit the of immature hematopoietic progenitor cells, whereas more mature, lineage-restricted progenitors are not inhibited. In contrast, in presence saturating concentrations granulocyte/macrophage-colony-stimulating (GM-CSF), TGF-beta promoted a 3- 5-fold increase number and size (greater than 0.5 mm) bone marrow colonies dose-dependent manner with an ED50 10-20 pM; alone had no effect. Morphological examination showed...
Influenza viruses frequently acquire mutations undergoing antigenic drift necessitating annual evaluation of vaccine strains. Highly conserved epitopes have been identified in the hemagglutinin (HA) head and stem regions, however, current influenza vaccines induce only limited responses to these sites. Here, we describe a novel seasonal recombinant HA nanoparticle (NIV) formulated with saponin-based adjuvant, Matrix-M™. NIV induced hemagglutination inhibition (HAI) microneutralizing (MN)...
Transcutaneous immunization (TCI) is a needle-free technique that delivers antigens and adjuvants to potent epidermal immune cells. To address critical unmet needs in biodefense against anthrax, we have designed novel vaccine delivery system using dry adhesive patch simplifies administration improves tolerability of subunit anthrax vaccine.Mice rabbits were vaccinated with recombinant protective antigen Bacillus anthracis the heat-labile toxin Escherichia coli. Serologic changes, levels...
Abstract Recently approved vaccines have already shown remarkable protection in limiting SARS-CoV-2 associated disease. However, immunologic mechanism(s) of protection, as well how boosting alters immunity to wildtype and newly emerging strains, remain incompletely understood. Here we deeply profiled the humoral immune response a cohort non-human primates immunized with stable recombinant full-length spike (S) glycoprotein (NVX-CoV2373) at two dose levels, administered single or two-dose...
ABSTRACT Vaccine strategies, such as influenza virus vaccination of the elderly, are highly effective at preventing disease but provide protection for only responding portion vaccinees. Adjuvants improve magnitude and rates responses, their potency must be attenuated to minimize side effects. Topical delivery strong adjuvants heat-labile enterotoxin from Escherichia coli (LT) induces potent immune responses. We hypothesized that LT delivered alone in an immunostimulating (LT-IS) patch placed...