A5089244860- Biochemical Analysis and Sensing Techniques
- Coffee research and impacts
- Ion Channels and Receptors
- Olfactory and Sensory Function Studies
- Polyamine Metabolism and Applications
- Folate and B Vitamins Research
- Muscle metabolism and nutrition
- Fungal Biology and Applications
- Plant chemical constituents analysis
- Catalysis for Biomass Conversion
- Carbohydrate Chemistry and Synthesis
- Natural product bioactivities and synthesis
- Chromatography in Natural Products
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Dye analysis and toxicity
- Metabolism and Genetic Disorders
- Plant Pathogens and Fungal Diseases
- Piperaceae Chemical and Biological Studies
Nestlé (Switzerland)
2008-2015
Background and purpose: Oily extracts of Sichuan Melegueta peppers evoke pungent sensations mediated by different alkylamides [mainly hydroxy‐α‐sanshool (α‐SOH)] hydroxyarylalkanones (6‐shogaol 6‐paradol). We assessed how transient receptor potential ankyrin 1 (TRPA1) TRP vanilloid (TRPV1), two chemosensory ion channels, participate in these sensations. Experimental approach: The structure–activity relationships molecules on TRPA1 TRPV1 was measured testing natural synthetic analogues using...
A systematic investigation of the human metabolism hydroxycinnamic acid conjugates was carried out. set 24 potential metabolites coffee polyphenols has been chemically prepared, and used as analytical standards for unequivocal identifications. These included glucuronide sulfate esters caffeic, ferulic, isoferulic, m-coumaric p-coumaric acids well their dihydro derivatives. particular focus made on caffeic 3,4-dihydroxyphenylpropionic derivatives, especially conjugates, which regioselective...
Szechuan pepper is widely used in Asia as a spice for its pleasant pungent and tingling sensations, produced by natural alkylamides called sanshools. alpha-Hydroxysanshool, the main alkylamide found pericarp of fruit, stimulates sensory neurons innervating mouth targeting two chemosensitive members transient receptor potential (TRP) channels, TRPV1 TRPA1. As it was previously that configuration unsaturations alpha-hydroxysanshool alkyl chain required TRPA1 but not selectivity, this study...
A novel synthesis of 5-O-feruloylquinic acid, a polyphenolic compound found in coffee beans, and its methyl ester derivative has been optimized. The sequence involves 6 steps is compatible with the preparation potential human metabolites these compounds. key reaction Knoevenagel condensation 4-hydroxy-3-methoxy-benzaldehyde malonate quinic acid.
Feruloylquinic acids are a major class of biologically active phenolic antioxidants in coffee beans, but their metabolic fate is poorly understood. The present study investigated the phase II metabolism feruloylquinic with selected human sulfotransferases (SULT1A1 and SULT1E1) uridine 5'-diphosphoglucuronosyltransferases (UGT1A1 UGT1A9). For unequivocal metabolite identification, chemical synthesis two potential metabolites 5-O-feruloylquinic acid, 4'-sulfated 4'-O-glucuronidated conjugates,...