Salvage chemotherapy has curative potential in germ cell tumors (GCTs). However, novel therapies are still needed for patients failing to be cured with standard salvage chemotherapy. Bevacizumab combination clinical activity many solid tumors. This is the first study of bevacizumab oxaliplatin refractory GCT patients.Patients metastatic progressive disease after second-line or later were eligible. Prior high-dose and paclitaxel and/or gemcitabine required unless primary mediastinal...

Abstract This study assessed the tobacco smoking-associated risk for tuberculous pleural effusion (TPE) in India. Ninety-two patients with TPE and 184 controls were randomly selected regarding their tobacco-smoking status type, quantity duration of used. Odds ratios (ORs) association smoking cigarette, beedi cigarette or 19.22 ( p < 0.0001), 2.89 = 0.0006) 4.57 0.0001) respectively. ORs developing increased an increase beedi/cigarette consumption, pack years 0.001 each). was significantly...

Background: Iatrogenic injury to the femoral vessel is a rare complication after fracture of hip. Pseudoaneurysm formation superficial artery or profunda femoris detected quite late. We present our experience for surgical management pseudoaneurysm iatrogenic trauma during femur. Methods: A retrospective analysis was carried out eight patients with treated surgically last 10 years in one unit. Results: Of artery, six had aneurysm and two aneurysm. Mean duration presentation 4 months (range...

To identify and assess the consequences of mutation in myelin-deficient (md) rats, myelin proteolipid protein (PLP) gene its expression were studied md rats. Southern blots PLP demonstrated that no major deletions or insertions have occurred this gene. In addition, does not result a splicing defect RNAs, since all exons are represented RNAs. These data consistent with results another laboratory indicating point rats single amino acid alteration protein. elucidate molecular mechanisms...

Endoscopic third ventriculostomy (ETV) is mostly safe but may have serious complications. Most of the complications are inherent to procedure's intra-axial nature. This study aimed explore an alternative route overcome issues with conventional ETV. The authors performed supraorbital, subfrontal extra-axial ETV (EAETV) via lamina terminalis.This prospective began in October 2021 and included patients obstructive triventricular hydrocephalus a Glasgow Coma Scale score 8 or more minimum...

Omental cysts are rare abdominal lesions and difficult to diagnose. Mostly they detected incidentally during imaging studies performed for unrelated reasons.Presentation can be both acute chronic. Acute presentations usually due complication in cyst. Imaging is helpful excluding other causes of lump abdomen. We encountered a case giant lymphatic cyst presenting with swelling, clinically mimicking huge ovarian cyst.The goal surgical therapy complete excision the cyst, removed without...

Microalbuminuria is a risk factor for cardiovascular disease. It gaining importance as marker of atherogenic milieu and indicates the target organ damage can be valuable tool in screening identification patients with Markers inflammation, such C-reactive protein (CRP), were found to related disease (CVD) events chest pain. In addition, recent studies have shown that, case atherosclerosis, increased levels CRP, reflects inflammatory condition vessel wall. present study, CRP microalbuminuria...

Abstract Spinal tumors extending up to two levels can be removed using minimally invasive techniques. A microscope is traditionally used as a visualization tool with the tubular-retractor system. An exoscope newer optical improved digital resolution, panoramic view, and better ergonomics for surgery. 36-year-old who presented paraparesis was diagnosed intradural extramedullary tumor in T7-T8 region. complete resection possible tubular retractors exoscope. The patient recovered clinically. We...

Endoscopic third ventriculostomy is a safe alternative to ventriculo-peritoneal shunt for certain cases of obstructive hydrocephalus. It has the advantage not leaving permanent foreign body in-situ, besides preventing over-drainage and reducing chances infection. A thorough knowledge endoscopic anatomy ventricles must performing various procedures.The aim this study was demonstrate educational purpose.ETV done using zero-degree LOTTA endoscope. Right Kocher's point usually chosen as entry...

Spondylodiscitis is on rise due to increasing elderly population and immunocompromised people now gets early detected imaging. Percutaneous Transforaminal Endoscopic Discectomy Drainage (PTELDD), simple procedure that yields high culture wihich helps in specific targeted antimicrobial bombardment. Dr. Satishchandra Gore has been pioneer introducing transforaminal endoscopy India way back 1999. His persistent efforts made inroads into traditional spine care treatments bandwagon flying many...

ABSTRACT Objective: Type II odontoid fractures need surgical stabilization for disabling neck pain and instability. Anterior screw fixation is a well-known technique. However, certain patients require posterior fixation. We present our results experiences with nine cases managed by the Goel-Harms Materials Methods: This retrospective review of operated on between January 2019 December 2021 Their clinical profile was collected from case files. The radiological data were retrieved radiology...

INTRODUCTION: In the quest for better alternatives open transforaminal lumbar interbody fusion (TLIF), minimally invasive surgery-TLIF (MIS-TLIF) has evolved, and feasibility studies of endoscopic are also getting reported in western literature. However, cost instrumented expandable cage may make it non-feasible Indian setup whenever will be commercially available.METHODS: This is a retrospective study 13 patients single-level percutaneous decompression cageless bone graft TLIF with pedicle...

Abstract Agressive angiomyxoma is a rare mesenchymal neoplasm. It mainly presents in females. We here present case of presenting as huge abdominal lump along with gluteal swelling. Case note described brief review literature.