A5052197564- Cancer-related Molecular Pathways
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Advanced Breast Cancer Therapies
- interferon and immune responses
- Advanced Nanomaterials in Catalysis
- Chemical Reactions and Isotopes
- Nanocluster Synthesis and Applications
- Antibiotic Resistance in Bacteria
- Veterinary medicine and infectious diseases
- Gold and Silver Nanoparticles Synthesis and Applications
- RNA and protein synthesis mechanisms
- Bacterial Genetics and Biotechnology
- Diagnosis and treatment of tuberculosis
University of California, Santa Cruz
2022-2025
Indian Institute of Science Education and Research Thiruvananthapuram
2019
Cyclin F, a non-canonical member of the cyclin protein family, plays critical role in regulating precise transitions cell-cycle events. Unlike canonical cyclins, which bind and activate cyclin-dependent kinases (CDKs), F functions as substrate receptor within Skp1-Cullin-F box (SCF) E3 ubiquitin ligase complex, enabling ubiquitylation target proteins. The structural features that distinguish adaptor mechanisms underlying its selective recruitment over A, complex with CDK2 at similar time...
Abstract Cyclin dependent kinase 2 (CDK2) regulates cell cycle and is an emerging target for cancer therapy. There are relatively small numbers of tumor models that exhibit strong dependence on CDK2 undergo G1 arrest following inhibition. The expression P16INK4A cyclin E1 determines this sensitivity to co-expression these genes occurs in breast patients highlighting their clinical significance as predictive biomarkers CDK2-targeted therapies. In genetically independent CDK2, pharmacological...
ABSTRACT Mfd is a highly conserved ATP dependent DNA translocase that mediates the role of Transcription-Coupled-DNA-Repair(TCR) in bacteria. The molecular mechanisms and conformational remodelling occurs upon binding, hydrolysis, translocation are poorly defined. Here we report series crystal electron microscopy(EM) structures from Mycobacterium tuberculosis (MtbMfd) smegmatis Mfd, solved both apo nucleotide-bound states. reveal mechanism nucleotide-binding, which lead to remodeling Walker...
Abstract The retinoblastoma protein (Rb) and its homologs p107 p130 are critical regulators of gene expression during the cell cycle. Functional inactivation Rb family proteins leads to loss cell-cycle control promotes genome instability proliferation, which hallmarks cancer. share a structural domain, known as “pocket domain”, mediates association with large number cellular proteins. A cleft in pocket domain binds an LxCxE sequence motif these proteins, many function co-regulate...