A5044202299- Advanced Polymer Synthesis and Characterization
- biodegradable polymer synthesis and properties
- Surfactants and Colloidal Systems
- Glycosylation and Glycoproteins Research
- Polymer Surface Interaction Studies
- Lipid Membrane Structure and Behavior
- Nanoparticle-Based Drug Delivery
- Pickering emulsions and particle stabilization
- Machine Learning in Materials Science
- Supramolecular Self-Assembly in Materials
- Photopolymerization techniques and applications
- Microplastics and Plastic Pollution
- Chemical Synthesis and Analysis
- Nanoplatforms for cancer theranostics
- Advanced Photocatalysis Techniques
- Innovative Microfluidic and Catalytic Techniques Innovation
- Hydrogels: synthesis, properties, applications
- Carbon dioxide utilization in catalysis
- Block Copolymer Self-Assembly
- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Nanocluster Synthesis and Applications
- Photodynamic Therapy Research Studies
- Characterization and Applications of Magnetic Nanoparticles
- SARS-CoV-2 detection and testing
Centre National de la Recherche Scientifique
2015-2025
Université de Lorraine
2013-2025
Laboratoire de Chimie-Physique Macromoléculaire
2019-2024
Laboratoire de Chimie Physique
2013-2022
Laboratoire de Chimie des Polymères Organiques
2015-2022
Université de Bordeaux
2015-2022
École Nationale Supérieure de Chimie, de Biologie et de Physique
2015-2019
Institut des Molécules et Matériaux du Mans
2015-2016
Le Mans Université
2015-2016
Université Nantes Angers Le Mans
2015-2016
Hybrids, i.e., intimately mixed polymer/phospholipid vesicles, can potentially marry in a single membrane the best characteristics of two separate components. The ability amphiphilic copolymers and phospholipids to self-assemble into hybrid membranes has been studied until now on submicrometer scale using optical microscopy giant unilamellar vesicles (GHUVs), but limited information is available large (LHUVs). In this work, based poly(dimethylsiloxane) poly(ethylene oxide) with different...
Self-assembly of polysaccharide-containing amphiphilic copolymers: polymerization induced self-assembly<italic>versus</italic>traditional techniques.
Herein, we report a detailed investigation on the influence of series tertiary alkylamine rate photoinduced electron transfer–reversible addition–fragmentation chain transfer (PET-RAFT) polymerization under visible light in presence and absence oxygen using Eosin Y as photo-organocatalyst. Most importantly, discovered that simple increase alkyl length substituents alkylamines leads to an enhanced PET-RAFT its tolerance oxygen. This study contributes fundamental comprehension process role...
A broad set of advanced glyco-nanostructures, rarely obtained as vesicles or never reported wormlike micelles, is using photo-initiated Polymerization-Induced Self-Assembly (Photo-PISA).
Phase separation in giant polymer/lipid hybrid unilamellar vesicles (GHUVs) has been described over the last few years. However there is still a lack of understanding on physical and molecular factors governing phase such systems. Among these parameters it suggested that analogy to multicomponent lipid hydrophobic mismatches as well fluidity play role. In this work, we aim map global picture domain formation membrane GHUVs by using various copolymers based poly(dimethylsiloxane) (PDMS)...
Polymersomes are multicompartmental vesicular nano-objects obtained by self-assembly of amphiphilic copolymers. When prepared in the aqueous phase, they composed a hydrophobic bilayer enclosing water. Although such fascinating polymeric have been widely reported with synthetic block copolymers, their formation from polysaccharide-based copolymers remains significant challenge. In present study, powerful platform technology known as polymerization-induced was used to prepare situ pure...
In recent years, artificial intelligence (AI) has emerged as a transformative tool for addressing scientific and technical challenges across various disciplines. AI enables data-driven predictions, uncovers hidden patterns, automates labor-intensive tasks, offering unprecedented opportunities innovation. However, its rapid rise been disruptive, many fields—including polymer science—were not fully prepared integration. The complexity of systems, coupled with the traditionally empirical nature...
The morphological evolution of graft copolymer-based nano-objects was monitored by light scattering and electron microscopy during their formulation in water polymerization induced self-assembly using a photo-mediated reversible addition–fragmentation chain transfer mechanism. copolymer models used were composed dextran backbone bearing poly(2-hydroxypropyl methacrylate) grafts two degrees (X). At full monomer conversion, unilamellar vesicles (ULVs) large compound (LCNs) formed when...
The self-assembly methods and the temperature have a considerable impact on morphology of resulting nanoobjects in case amphiphilic glycopolymers.
Here, heterogeneous photoinduced electron transfer-reversible addition fragmentation chain transfer (PET-RAFT) polymerization of methyl methacrylate (MMA) was carried out under 405 nm irradiation without prior deoxygenation the reaction medium using urea-based graphitic nitride (U-g-C3N4) as a photocatalyst. The impact each constituent, including U-g-C3N4, agent (CTA), and tertiary amine (TA), on control its tolerance toward oxygen discussed. We found that U-g-C3N4/CTA photocatalytic system...
For the first time, polymersomes were obtained by self-assembly in water of amphiphilic grafted glycopolymers based on dextran polysaccharidic backbone and polymeric liquid crystal grafts (poly(diethylene glycol cholesteryl ether acrylate), PDEGCholA). After measuring properties these term surfactancy, influence their structural parameters self-assemblies once dispersed was investigated static dynamic light scattering cryogenic transmission electron microscopy (cryo-TEM). Based results, a...
Abstract Currently, the phase transition of aqueous binary systems containing thermoresponsive (co)polymers, and exhibiting upper critical solution temperature (UCST), is exclusively investigated in dilute solutions, which can limit knowledge their UCST‐type transition. Herein, a photo‐RAFT polymerization approach, using acrylamide (AAm) acrylonitrile (AN) as monomer models, used to prepare well‐controlled poly(AAm‐ co ‐AN) copolymers “in situ” highly concentrated dispersions (60 wt%). The...
During last few decades, oligochitosan (OCS)-coated nanoparticles have received great interest for nanomedicine, food and environment applications. However, their current formulation techniques are time-consuming with multi-synthesis/purification steps sometimes require the use of organic solvents, crosslinkers surfactants. Herein, we report a facile rapid one-pot synthesis OCS-based using photo-initiated reversible addition fragmentation chain transfer polymerization-induced self-assembly...
Herein, we report a multistep synthesis of novel (meth)acrylate monomers based on gallic acid (GA), biosourced phenolic acid. The objective this work was to obtain bio-based polymers exhibiting antioxidant properties provided by derived from groups GA, which are responsible for properties, need be protected two reasons. On the one hand, functionalization transform GA into polymerizable must not take place at because they remain free maintain maximum activity in final polymers. other their...
Tumor necrosis factor receptor 2 (TNFR2) is expressed on some tumor cells, such as myeloma, Hodgkin lymphoma, colon cancer and ovarian cancer, well immunosuppressive cells. There increasingly evidence that TNFR2 expression in microenvironment has significant implications progression, metastasis immune evasion. Although nanomedicine been extensively studied a carrier of immunotherapeutic agents, no study to date investigated TNFR2-targeting treatment. From an epigenetic perspective, previous...
Polysaccharide coated nanoparticles represent a promising class of environmentally friendly latex to replace those stabilized by small toxic molecular surfactants. We report here an in situ formulation free-surfactant core/shell consisting dextran-based diblock amphiphilic copolymers. The synthesis copolymers and the immediate were performed directly water using photo-initiated reversible addition fragmentation chain transfer-mediated polymerization induced self-assembly strategy. A...
ABSTRACT A cholesterol‐based liquid crystal monomer, diethylene glycol cholesteryl ether acrylate (DEGCholA), has been successfully polymerized by atom transfer radical polymerization (ATRP) for the first time. Appropriate experimental conditions to control of DEGCholA have investigated using a model initiator (ethyl 2‐bromoisobutyrate) in tetrahydrofuran (THF) or toluene at 60 °C. Well‐controlled ATRP was obtained N , ′, ″‐pentamethyldiethylenetriamine as ligand THF These were then applied...